Results 61 to 70 of about 49,667 (305)

Vm–MSI: a Vancomycin–Antimicrobial Peptide Conjugate Combating Resistant Bacteria and Broadening the Antimicrobial Spectrum

Advanced Science, EarlyView.
A series of vancomycin‐antimicrobial peptide conjugates is synthesized and evaluated to identify the optimal combination. Vm‐MSI, selected from multiple candidates, exhibited potent activity against vancomycin‐resistant and Gram‐negative bacteria by disrupting membranes and inducing oxidative stress, thereby expanding vancomycin's antibacterial ...
Shuangyu Li, Kang Wang, Wenzhuang Shi, Xu Wang, Duxin Li, Yanli Liu, Peng Zhang, Yipeng Wang   +7 more
wiley   +1 more source

Formation of Condition‐Dependent Alpha‐Synuclein Fibril Strain in Artificial Cerebrospinal Fluid

Advanced Science, EarlyView.
α‐synuclein aggregation in artificial cerebrospinal fluid (aCSF) leads to a distinct conformation with an electron density pocket motif found in aggregates from PD and MSA patients. Such fibrils has low stability outside the reaction conditions, hinting about the influence of cerebrospinal fluid components not only on the formation, but also on the ...
Rūta Sniečkutė, Darius Šulskis, Arūnė Jocytė, Urtė Venclovaitė, Rimgailė Tamulytė, Mantas Žiaunys, Vytautas Smirnovas, Andrius Sakalauskas   +7 more
wiley   +1 more source

A Methodology for Deciphering the Transmembrane Resistance Variability of Supported Lipid Bilayers

Advanced Science, EarlyView.
This work shows that transmembrane resistance variability, due to lipid packing defects, can be quantified by analysing the dielectric properties of Supported Lipid Bilayers. The proposed methodology provides an analytical tool for optimizing SLB design with improved stability and functionality for bioelectronic and biomimetic applications. Abstract In
Aristea Pavlou, Debdatta Panigrahi, Somayeh Kashani, Anna‐Maria Pappa, Fabrizio Torricelli, Paul W.M. Blom, Paschalis Gkoupidenis   +6 more
wiley   +1 more source

Rhizome de l’écosystème du numérique universitaire français et nouvelle gouvernance : Mutualisation, gouvernance et numérique universitaire

Médiations & Médiatisations
Nous proposons de caractériser l’organisation du numérique universitaire français, en examinant ses processus de fabrication, de fonctionnement et de gouvernance en interrogeant le concept de rhizome, développé en 1980 par Deleuze et Guattari.
Bertrand Mocquet
doaj   +1 more source

Red Blood Cells Internalize Extracellular DNA via Apoptotic Bodies with Clinical Relevance to Cancer Patients

Advanced Science, EarlyView.
Mature red blood cells (RBCs) can capture extracellular DNA, with short fragments homologous to cfDNA. This uptake is mediated by apoptotic bodies, which induce RBC oxidative stress, deformation, and accelerated in vivo clearance. The rbcDNA abundance correlates with tumor burden and therapeutic response, highlighting its potential as a liquid biopsy ...
Zihang Zeng, Zongbi Yi, Jing Hu, Jiali Li, Yu Xu, Xiuli Guo, Qian Ji, Kaixiang Feng, Ying Zhang, Sirui Bai, Yushuang Tan, Yufei Yan, Linzhi Han, Jing Jiang, Tengfei Wang, Xiang Wang, Ziqing Zhan, Ruiying Huang, Jinfang Zhang, Conghua Xie, Binghe Xu   +20 more
wiley   +1 more source

Biodistribution and dosimetry of the PET radioligand [18F]CHDI-650 in mice for detection of mutant huntingtin aggregates

EJNMMI Research
Background Huntington’s disease (HD) is a rare neurodegenerative disorder caused by an expansion of the CAG trinucleotide repeat in the huntingtin gene which encodes the mutant huntingtin protein (mHTT) that is associated with HD-related ...
Jordy Akkermans, Alan Miranda, Jeroen Verhaeghe, Filipe Elvas, Franziska Zajicek, Jonathan Bard, Longbin Liu, Vinod Khetarpal, Robert Doot, Steven Staelens, Daniele Bertoglio   +10 more
doaj   +1 more source

Origin and properties of kaolinites from soils of a toposequence in Southern Brazil [PDF]

Revista Brasileira de Ciência do Solo
Kaolinite is the main clay mineral in most soils around the world and has been widely used for industrial purposes. This research aimed to study chemical, morphological and crystallographic characteristics of kaolinite, and establish the origin of ...
Daniela Nicole Ferreira, Vander de Freitas Melo, Samara Alves Testoni, Pablo Vidal-Torrado, Jairo Calderari de Oliveira Junior   +4 more
doaj   +1 more source

Unpaired Learning‐Enabled Nanotube Identification from AFM Images

Advanced Science, EarlyView.
Identifying nanotubes on rough substrates is notoriously challenging for conventional image analysis. This work presents an unpaired deep learning approach that automatically extracts nanotube networks from atomic force microscopy images, even on complex polymeric surfaces used in roll‐to‐roll printing.
Soyoung Na, Soobin Park, Younsu Jung, Jinhwa Park, Jimin Hong, Jihyun Lee, Albert Kim, Bongjun Kim, Gyoujin Cho, Eunju Cha, Seung Hyun Song   +10 more
wiley   +1 more source

GENERAL AND SPECIFIC COMBINING ABILITY OF TROPICAL MAIZE GERMPLASM

Tropical and Subtropical Agroecosystems, 2008
Eight tropical maize populations were crossed in a diallel system. Parent and their 28 crosses were evaluated for grain yield in two plantations in 2006.
Pedro Guillen de la Cruz, Efraín De La Cruz Lázaro, Guillermo Castañon Najera, Rodolfo Osorio Osorio, Nancy Patricia Brito Manzano, Alejandro Lozano del Río, Ulises López Noverola   +6 more
doaj  

Population‐Based Multi‐Omics and Cohort Study Identifying Predictive Biomarkers and Therapeutic Targets for Psoriatic Disease

Advanced Science, EarlyView.
Psoriatic disease (PsD) is a chronic skin disease, with challenges in early risk stratification and drug development. Through gene‐level causal inference framework and expression level validation, combined with longitudinal cohort study, CDSN and PRSS8 have been identified as candidate biomarkers and therapeutic targets for PsD.
Tianxing Wu, Jialiang Luo, Haoyuan Qiu, Weijie Shao, Yueyang Lu, Meixuan Luo, Zhaofeng Lin, Yan Zhang, Libo Zhang, Hong Wang, Jia Zhou, Guangfeng Ruan, Peihua Cao, Daming Zuo   +13 more
wiley   +1 more source