Results 111 to 120 of about 2,949,186 (311)

BACE1 in the retina: a sensitive biomarker for monitoring early pathological changes in Alzheimer′s disease

Neural Regeneration Research, 2016
Because of a lack of sensitive biomarkers, the diagnosis of Alzheimer′s disease (AD) cannot be made prior to symptom manifestation. Therefore, it is crucial to identify novel biomarkers for the presymptomatic diagnosis of AD.
Lan Li, Jia Luo, Dan Chen, Jian-bin Tong, Le-ping Zeng, Yan-qun Cao, Jian Xiang, Xue-gang Luo, Jing-ming Shi, Hui Wang, Ju-fang Huang   +10 more
doaj   +1 more source

Comprehensive mutagenesis identifies the peptide repertoire of a p53 T-cell receptor mimic antibody that displays no toxicity in mice transgenic for human HLA-A*0201. [PDF]

PLoS One, 2021
Trenevska I, Anderson AP, Bentley C, Hassanali T, Wiblin S, Maguire S, Pezzella F, Banham AH, Li D.   +8 more
europepmc   +1 more source

Transgenic Overexpression of LARGE Induces alpha-Dystroglycan Hyperglycosylation in Skeletal and Cardiac Muscle [PDF]

, 2010
Background: LARGE is one of seven putative or demonstrated glycosyltransferase enzymes defective in a common group of muscular dystrophies with reduced glycosylation of alpha-dystroglycan.
Paul S Sharp, Dominic J. Wells, Ke Liu, Susan C Brown, Sharp, P S, Dominic J Wells, Cirak, S., Sebahattin Cirak, Wells, DJ, Paul S. Sharp, Muntoni, F., Susan C. Brown, Wells, D J, Brockington, M., Cirak, S, Liu, K., Brockington, M, Torelli, S, Brown, SC, Sharp, PS, Muntoni, F, Brown, S C, Sharp, P.S., Torelli, S., Liu, K, Wells, D.J., Silvia Torelli, Brockington, M A, Francesco Muntoni, Martin Brockington, Brown, S.C.   +30 more
core   +1 more source

Self‐Assembly of Antigenic Peptide Nanofibrils Templates the Growth of Silica Nanoparticles for Nanovaccines

Advanced Science, EarlyView.
Antigenic peptides Aβ42 and E7 self‐assemble into nanofibrils; APTES and TEOS induce SiO2 NP formation on these fibrils to form SiO2@fibril nanovaccines, which activate BMDCs in vitro. In vivo, SiO2@Aβ42 fibril nanovaccines alleviate AD symptoms and clear Aβ42 plaques in APP/PS1 mice, and SiO2@E7 fibril nanovaccines inhibit tumor growth and promote ...
Xuecheng Yang, Min Li, Zhiying Yao, Yu Hu, Zhili Wang, Wendi Shi, Bingbing Sun   +6 more
wiley   +1 more source

Cognitive abilities of Alzheimer's disease transgenic mice are modulated by social context and circadian rhythm [PDF]

, 2011
In the present study, we used a new training paradigm in the intelliCage automatic behavioral assessment system to investigate cognitive functions of the transgenic mice harboring London mutation of the human amyloid precursor protein (APP.V717I).
Kiryk, Anna, Gorkiewicz, Tomasz, Leski, S, Lipp, H P, Mochol, Gabriela, Mochol, G, Balcerzyk, Marcin, Szymon Leski, Kiryk, A, Leski, Szymon, Robert K. Filipkowski, Filipkowski, Robert K., Lioudyno, Victoria, Daniel K. Wojcik, Wawrzyniak, M, Gorkiewicz, T, Kaczmarek, Leszek, Balcerzyk, M, Kaczmarek, L, Marcin Balcerzyk, Fred Van Leuven, Anna Kiryk, Marcin Wawrzyniak, Knapska, E, Lipp, Hans-Peter, Filipkowski, R K, Leszek Kaczmarek, Lioudyno, V, Hans-Peter Lipp, Victoria Lioudyno, Wojcik, D K, Wawrzyniak, Marcin, Van Leuven, F, Knapska, Ewelina, Ewelina Knapska, Tomasz Gorkiewicz, Van Leuven, Fred, Wójcik, Daniel K., Gabriela Mochol   +38 more
core   +1 more source

SOX5 Orchestrates Malignant Evolution via Promoter‐Centric Chromatin Remodeling in MYC‐Driven B‐Cell Lymphoma

Advanced Science, EarlyView.
In MYC‐enforced B‐cell lymphoma, SOX5 occupies promoter‐proximal regulatory regions and is associated with reduced chromatin accessibility at the PCNP locus. PCNP repression promotes proliferative remodeling by limiting apoptosis and cell‐cycle restraint.
Yiyou Mao, Zhenyuan Jia, Xiao‐Qin Mu, Ruilin Wang, Jianli Ma, Qingyuan Zhang, Yuwei Deng   +6 more
wiley   +1 more source

Transgenic fish and aquaculture [PDF]

, 1995
Transgenic fish species can be routinely produced by transferring foreign DNA into developing embryos via microinjection or electroporation. This technology offers an excellent opportunity for modifying or improving the genetic traits of commercially ...
Chen, Thomas T.
core   +1 more source

Pathological impact of hepatitis B virus surface proteins on the liver is associated with the host genetic background.

PLoS ONE, 2014
BackgroundWhile the immune pathogenesis caused by hepatitis B virus (HBV) infection has been studied extensively, little is known about direct pathogenic effects of HBV surface proteins.
Yuri Churin, Martin Roderfeld, Johannes Stiefel, Tilman Würger, Dirk Schröder, Tomomitsu Matono, Hans-Joachim Mollenkopf, Roberta Montalbano, Malvika Pompaiah, Kurt Reifenberg, Daniel Zahner, Matthias Ocker, Wolfram Gerlich, Dieter Glebe, Elke Roeb   +14 more
doaj   +1 more source

Lack of human-like extracellular sortilin neuropathology in transgenic Alzheimer’s disease model mice and macaques

Alzheimer’s Research & Therapy, 2018
Background Alzheimer’s disease (AD) is a devastating neurodegenerative disorder bearing multiple pathological hallmarks suggestive of complex cellular/molecular interplay during pathogenesis.
Feng-Qin Zhou, Juan Jiang, Chelsea M. Griffith, Peter R. Patrylo, Huaibin Cai, Yaping Chu, Xiao-Xin Yan   +6 more
doaj   +1 more source

The role of host PrP in Transmissible Spongiform Encephalopathies [PDF]

, 2007
PrP has a central role in the Transmissible Spongiform Encephalopathies (TSEs), and mutations and polymorphisms in host PrP can profoundly alter the host's susceptibility to a TSE agent.
Barron, Rona M, Wiseman, Frances, Barron, Rona, Hart, Patricia, Manson, Jean C., Wiseman, Patricia, Cancellotti, Enrico, Bishop, Matthew T., Barron, Rona M., Bishop, Matthew T, Manson, Jean C   +10 more
core   +1 more source