Results 271 to 280 of about 1,759,640 (316)

Measurement of Anxiety in Transgenic Mice

Reviews in the Neurosciences, 2000
A wide range of approaches has been used to study anxiety in mice. All presuppose that aversive stimuli, such as foot shock or novelty, induce a central state of fear, which can be quantified through specific behavioural and physiological measures. This review discusses the validity of the various approaches in terms of their similarity to different ...
S M, Weiss, S, Lightowler, K J, Stanhope, G A, Kennett, C T, Dourish   +4 more
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Reporter genes in transgenic mice

Transgenic Research, 1994
Although in vivo models utilizing endogenous reporter genes have been exploited for many years, the use of reporter transgenes to dissect biological issues in transgenic animals has been a relatively recent development. These transgenes are often, but not always, of prokaryotic origin and encode products not normally associated with eukaryotic cells ...
C, Cui, M A, Wani, D, Wight, J, Kopchick, P J, Stambrook   +4 more
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Insertional mutagenesis in transgenic mice

Transgenic Research, 1994
Increasing numbers of transgenic mouse lines have resulted in several dozens of mutants created by insertional mutagenesis. The advantages of different vector systems and the problems associated with the analysis of mutations and the cloning of the affected genes are discussed in this review.
T, Rijkers, A, Peetz, U, Rüther
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Transgenic mice in apoptosis research

Apoptosis, 1998
Transgenic mice have proved to be a valuable tool in various aspects of apoptosis research. They are particularly useful for studying apoptosis-related gene products in primary cells which may lead to different effects from similar experiments using immortalized cell lines.
G, Gil-Gómez, H J, Brady
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Transgenic mice

Cell, 1985
R D, Palmiter, R L, Brinster
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Histological Examination of Transgenic Mice

2003
Histological examination is important to detect and differentiate among different types of tissue changes at the microscopic level. An enlarged organ can be hyperplastic, hypertrophied, or neoplastic. It can also be merely inflamed or infected. Only a histological examination can differentiate among the various growth disturbances and pathological ...
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Transgenic mice and the pathogenesis of poliomyelitis

1994
Transgenic mice expressing the cell receptor for poliovirus have been generated and are susceptible to poliovirus infection. TgPVR mice have been used to answer questions about the pathogenesis of poliovirus infection. Despite the widespread pattern of PVR expression, poliovirus infection in TgPVR mice is restricted to only a few sites, indicating that
V R, Racaniello, R, Ren
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Transgenic RNA Interference in Mice

2008
RNA interference (RNAi) is a powerful tool in deciphering gene function. It has been used extensively, especially in cultured mammalian cells. We have shown that RNAi-induced gene silencing can be generated in mice. With conventional transgenic techniques, shRNA-expressing constructs can be introduced into one-cell mouse embryos. The transgenic animals
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Oncogenes in transgenic mice

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1988
S J, Compere, P, Baldacci, R, Jaenisch
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Postmortem Examination of Transgenic Mice

2003
Postmortem examination of transgenic animals should ideally be performed by or with the help of a trained pathologist. This is because although the steps in the examination can be manually performed by anyone, the interpretation of the findings can only be done with the knowledge of veterinary medicine.
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