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A comprehensive evaluation of the human Tg32 and Tg276 FcRn transgenic mouse and non-human primate models for predicting antibody pharmacokinetics in human. [PDF]
MAbsGajewska M +8 more
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Downregulating <i>Nrl</i> Expression and Rod Photoreceptor Protection. [PDF]
Int J Mol SciLi Y, Jiao S, Tao W, Wen R.
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An Outflow Tract Myocardium-Specific Enhancer at the Sema3c Locus During Heart Development. [PDF]
Genes CellsWang Y +5 more
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In vivo self-assembled SOD1-siRNAs mitigate muscle atrophy and denervation in amyotrophic lateral sclerosis. [PDF]
BrainGuo J +11 more
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Effects of UMP, Choline, and Fish Oil on Synaptic Integrity and Motor Coordination in an Alzheimer's Disease Mouse Model. [PDF]
Int J Mol SciKeskinoz EN +14 more
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Paediatric Respiratory Reviews, 2006
For the past 20 years researchers have used transgenic mice to help understand the basic mechanisms associated with inherited human and animal diseases. The ability to integrate exogenous genetic information into the mouse genome has revolutionised the analysis of gene function.
Judy M, Hickman-Davis, Ian C, Davis
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For the past 20 years researchers have used transgenic mice to help understand the basic mechanisms associated with inherited human and animal diseases. The ability to integrate exogenous genetic information into the mouse genome has revolutionised the analysis of gene function.
Judy M, Hickman-Davis, Ian C, Davis
openaire +3 more sources
Genome, 1989
Stable integration into the mouse genome of exogenous genetic information has become, over the past few years, a very potent approach for different aspects of biology. It is a common feature that the integrated exogenous gene (the transgene) is expressed properly both spatially and temporally.
Babinet, C. +2 more
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Stable integration into the mouse genome of exogenous genetic information has become, over the past few years, a very potent approach for different aspects of biology. It is a common feature that the integrated exogenous gene (the transgene) is expressed properly both spatially and temporally.
Babinet, C. +2 more
openaire +3 more sources
Phototransduction in transgenic mice
Current Opinion in Neurobiology, 1996Transgenic mice provide a powerful tool for elucidating the molecular mechanisms of phototransduction. Mice expressing a phosphorylation-deficient rhodopsin and mice deficient in arrestin are being used to study shutoff of photoactivated rhodopsin. These in vivo mouse studies indicate that shutoff is partially mediated by rhodopsin phosphorylation ...
J, Lem, C L, Makino
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BioEssays, 1987
AbstractTransgenic mice constitute an entirely new dimension of mammalian molecular genetics. They allow us to observe genes at work in the intact organism. Virtually every sector of biomedical research is likely to be affected.
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AbstractTransgenic mice constitute an entirely new dimension of mammalian molecular genetics. They allow us to observe genes at work in the intact organism. Virtually every sector of biomedical research is likely to be affected.
openaire +2 more sources