Results 231 to 240 of about 1,759,640 (316)

Transgenic mouse models for investigating human DUX4 expression during development and its roles in FSHD pathophysiology. [PDF]

Dis Model Mech
Hiramuki Y, Himeda CL, Jones PL, Jones TI.   +3 more
europepmc   +1 more source

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

Enhanced splicing modulation by NMA-modified antisense oligonucleotides. [PDF]

Nucleic Acids Res
Ling K, Prakash TP, Yu J, Jackson M, Chun SJ, Bachmann G, Post N, Greenlee S, Soriano A, Hunyara JL, Norris DA, Jafar-Nejad P, Swayze EE, Bennett CF, Rigo F.   +14 more
europepmc   +1 more source

Humanized immune system animal models and their recent applications

Animal Models and Experimental Medicine, EarlyView.
In this review, we provide an updated and comprehensive overview of the current state of humanized immune system animal model research. We discuss the variety of techniques used to produce humanized mice with their respective strengths and weaknesses, and evaluate the advantages and limitations of these models, including issues with incomplete immune ...
Nicolas Skuli, Rudra B. Amin, A’ishah Bakayoko, Marisa Kruidenier, Sahara Aqui, Sarah J. Skuli, Terence P. Gade   +6 more
wiley   +1 more source

Applications of humanized mice in <i>Mycobacterium tuberculosis</i> infections (Review). [PDF]

Mol Med Rep
Han B, Liu F, Long J, Wang J, Cui Y, Yang H.   +5 more
europepmc   +1 more source

Recent advances in the construction of humanized animal models and applications in translational medicine

Animal Models and Experimental Medicine, EarlyView.
Substantial advances have been achieved in the development of humanized mouse models, which have proven highly valuable in evaluating cancer immunotherapies and elucidating the mechanisms of infectious diseases. There is now a growing shift in research toward larger animal models—such as pigs—that offer greater physiological similarity to humans ...
Yanan Lyu, Yong‐Guang Yang, Zheng Hu
wiley   +1 more source

RETRACTION: Antileukotriene Therapy by Reducing Tau Phosphorylation Improves Synaptic Integrity and Cognition of P301S Transgenic Mice. [PDF]

Aging Cell
europepmc   +1 more source

Synaptic Potentiation in Hippocampus by eEF2K Inhibitor A484954. [PDF]

Hippocampus
Yang Q, Li T, Jester HM, Su Q, Zhou X, Ryazanov AG, Ma T.   +6 more
europepmc   +1 more source

Chrysin alleviates pressure overload–induced myocardial remodeling through regulating the PI3K/AKT/NRF2 pathway–mediated oxidative stress response

Animal Models and Experimental Medicine, EarlyView.
In this study, we primarily simulated pathological myocardial remodeling induced by transverse aortic constriction surgery and found significant cardiac hypertrophy and fibrosis, characterized by deteriorated cardiac function. Oxidative stress response is considered as a pivotal pathological process, which contributes to inflammation and apoptosis of ...
Yijia Wang, Xing Feng, Shuhui Zhao, Yuchong Fu, Ao Zhang, Xiaofeng Shen, Bowen Yu, Yihao Wang, Jiahui Lin, Bing Zhang, Weiping Ji, Lianpin Wu, Xiaoling Guo   +12 more
wiley   +1 more source

Beware of your "oocyte specific" Cre line: somatic cell Cre expression in several Zp3-Cre lines and the Gdf9-iCre transgenic line†. [PDF]

Biol Reprod
Stein P, Emori C, Padilla-Banks E, Radonova L, Gruzdev A, Ikawa M, Williams CJ.   +6 more
europepmc   +1 more source