Results 241 to 250 of about 1,947,841 (302)
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Paediatric Respiratory Reviews, 2006
For the past 20 years researchers have used transgenic mice to help understand the basic mechanisms associated with inherited human and animal diseases. The ability to integrate exogenous genetic information into the mouse genome has revolutionised the analysis of gene function.
Judy M, Hickman-Davis, Ian C, Davis
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For the past 20 years researchers have used transgenic mice to help understand the basic mechanisms associated with inherited human and animal diseases. The ability to integrate exogenous genetic information into the mouse genome has revolutionised the analysis of gene function.
Judy M, Hickman-Davis, Ian C, Davis
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Genome, 1989
Stable integration into the mouse genome of exogenous genetic information has become, over the past few years, a very potent approach for different aspects of biology. It is a common feature that the integrated exogenous gene (the transgene) is expressed properly both spatially and temporally.
Babinet, C. +2 more
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Stable integration into the mouse genome of exogenous genetic information has become, over the past few years, a very potent approach for different aspects of biology. It is a common feature that the integrated exogenous gene (the transgene) is expressed properly both spatially and temporally.
Babinet, C. +2 more
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1995
CD5 is a glycoprotein expressed on all mature T cells [1], a small but distinct subset of B lymphocytes (referred to as Bla cells) [2], some mouse B cell lymphomas and most human chronic lymphocytic leukemias (CLL) [3,4]. Both human and mouse CD5 genes have been cloned.
X, Chen, Y, Matsuura, J F, Kearney
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CD5 is a glycoprotein expressed on all mature T cells [1], a small but distinct subset of B lymphocytes (referred to as Bla cells) [2], some mouse B cell lymphomas and most human chronic lymphocytic leukemias (CLL) [3,4]. Both human and mouse CD5 genes have been cloned.
X, Chen, Y, Matsuura, J F, Kearney
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BioEssays, 1987
AbstractTransgenic mice constitute an entirely new dimension of mammalian molecular genetics. They allow us to observe genes at work in the intact organism. Virtually every sector of biomedical research is likely to be affected.
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AbstractTransgenic mice constitute an entirely new dimension of mammalian molecular genetics. They allow us to observe genes at work in the intact organism. Virtually every sector of biomedical research is likely to be affected.
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Journal of Reproductive Immunology, 1999
We have generated a number of transgenic mice using DNA segments derived from the HLA-G gene. Using these mice we have examined the pattern of expression dictated by HLA-G promoter elements in mice and shown that HLA-G functions both as a restriction element and a transplantation antigen recognized by murine T cells.
A, Mellor, M, Zhou, S J, Conway, D, Munn
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We have generated a number of transgenic mice using DNA segments derived from the HLA-G gene. Using these mice we have examined the pattern of expression dictated by HLA-G promoter elements in mice and shown that HLA-G functions both as a restriction element and a transplantation antigen recognized by murine T cells.
A, Mellor, M, Zhou, S J, Conway, D, Munn
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Phototransduction in transgenic mice
Current Opinion in Neurobiology, 1996Transgenic mice provide a powerful tool for elucidating the molecular mechanisms of phototransduction. Mice expressing a phosphorylation-deficient rhodopsin and mice deficient in arrestin are being used to study shutoff of photoactivated rhodopsin. These in vivo mouse studies indicate that shutoff is partially mediated by rhodopsin phosphorylation ...
J, Lem, C L, Makino
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Transgenic Mice and Oncogenesis
Annual Review of Immunology, 1988The creation of transgenic mice carrying specific cancer-promoting genes has opened an exciting new era in oncology. The biological effects of an individual oncogene on diverse cell types can now be assessed directly within the living animal. While transgenic animals bear the introduced oncogene in every tissue, expression of that gene may either be ...
S, Cory, J M, Adams
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Methods, 1996
The ability to direct expression of genes to astrocytes in mice has been one of the major motivators of transcriptional analyses of the glial fibrillary acidic protein (GFAP) gene. Another has been the possibility of discovering signaling pathways that operate during development, disease, and injury-all states that increase GFAP gene activity-by ...
, Brenner, , Messing
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The ability to direct expression of genes to astrocytes in mice has been one of the major motivators of transcriptional analyses of the glial fibrillary acidic protein (GFAP) gene. Another has been the possibility of discovering signaling pathways that operate during development, disease, and injury-all states that increase GFAP gene activity-by ...
, Brenner, , Messing
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Pancreatology, 2001
Pancreatic cancer is a devastating disease with a fatal prognosis due to late diagnosis and resistance to radiation and chemotherapy. The average survival after diagnosis is still 3 to 8 months. In the last few years genetic alterations in cancer-causing genes have been identified in tumors and putative premalignant lesions using microdissection ...
Florian R. Greten +5 more
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Pancreatic cancer is a devastating disease with a fatal prognosis due to late diagnosis and resistance to radiation and chemotherapy. The average survival after diagnosis is still 3 to 8 months. In the last few years genetic alterations in cancer-causing genes have been identified in tumors and putative premalignant lesions using microdissection ...
Florian R. Greten +5 more
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2004
In this post-genomic era, emphasis has shifted from identifying genes to understanding the physiological functions of gene products and their implications in human diseases. The use of transgenic mice is one of the key approaches in elucidating gene function and regulation. Transgenic mice have wide applications in biomedical research. These include (1)
Guoping, Feng, Jing, Lu, Jimmy, Gross
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In this post-genomic era, emphasis has shifted from identifying genes to understanding the physiological functions of gene products and their implications in human diseases. The use of transgenic mice is one of the key approaches in elucidating gene function and regulation. Transgenic mice have wide applications in biomedical research. These include (1)
Guoping, Feng, Jing, Lu, Jimmy, Gross
openaire +2 more sources