Results 221 to 230 of about 1,947,841 (302)

High-Dose Voclosporin Protects Against Acute Kidney Injury via Regnase-2-Mediated NGAL MRNA Decay. [PDF]

Int J Mol Sci
Hasegawa K, Sakamaki Y, Tamaki M, Yamaguchi S, Miyakami S, Okinari C, Tada M, Otsuka M, Minato M, Wakino S.   +9 more
europepmc   +1 more source

Zebrafish and CRISPR—A synergistic approach to decipher and cure human diseases

Animal Models and Experimental Medicine, EarlyView.
Zebrafish, with high genetic homology to humans, serves as a powerful vertebrate model for disease modeling and drug discovery. Integration of CRISPR/Cas9 technology enables precise genome editing, facilitating the development of translational models for human diseases.
Manikandan Sivaprakasam, Aashika Raagavi Jeanpierre, Salma Mohammed, Rajesh Srinivasan, Aman Kumar Mohanty   +4 more
wiley   +1 more source

Microbiota Regulation of Duodenal Adenoma Development: Bile Acids Join the Team. [PDF]

Cell Mol Gastroenterol Hepatol
Yang W, Cong Y.
europepmc   +1 more source

Gorab deficiency in skin dermis accelerates aging and is associated with dysregulation of RCHY1‐mediated P53 ubiquitination

Animal Models and Experimental Medicine, EarlyView.
Based on a dermis fibroblast Gorab knockout mouse model, this study revealed that Gorab deficiency promotes skin aging by influencing RCHY1, causing a decrease in P53 ubiquitination, damaging the activity of HDAC2, further resulting in the accumulation of aging‐related proteins (P53, P21, P16) and a reduction in extracellular matrix (ECM) components ...
Yanhong Li, Wei Liang, Yanfeng Xu, Yunlin Han, Wenjie Zhao, Siyuan Wang, Wei Deng, Chuan Qin   +7 more
wiley   +1 more source

Direct Comparison of Constitutive Rax-Cre Transgenic Drivers That Activate in the Mouse Embryonic Eye Field. [PDF]

Invest Ophthalmol Vis Sci
Brown NL, Goodyear-Brown S, Fuhrmann S.
europepmc   +1 more source

Sex as a biological variable in nonclinical studies: Bridging scientific rigor, animal welfare, and regulatory expectations

Animal Models and Experimental Medicine, EarlyView.
Sex as a biological variable (SABV) is a critical determinant of pharmacokinetics, pharmacodynamics, and toxicity in nonclinical studies. This review highlights how inappropriate neglect of sex differences compromises animal welfare, scientific reproducibility, and regulatory compliance.
Kenta Onuma, Masaki Watanabe, Nobuya Sasaki   +2 more
wiley   +1 more source

Impaired nucleocytoplasmic transport in SOD1-mediated ALS. [PDF]

Mol Neurodegener
Argueti-Ostrovsky S, Lim SM, Arogundade OA, Diaz-Garcia S, Yunisova G, Meng A, Hermann A, Ong K, Eremenko E, Bravo-Hernandez M, Driscoll SP, Lee CZ, Jiang X, Stavsky A, Barel S, Shani T, Kahn J, Pfaff SL, Monsonego A, Marsala M, Ravits J, Lagier-Tourenne C, Israelson A.   +22 more
europepmc   +1 more source

Evaluation of quantitative muscle MRI and an intelligent phenotyping housing system as advanced phenotyping methods in a mouse model of calpain 3‐deficient muscular dystrophy

Animal Models and Experimental Medicine, EarlyView.
We applied quantitative MRI of the lower limb and automated home‐cage phenotyping to a mouse model of calpainopathy to detect early disease changes. At 15 months, calpain 3‐deficient mice showed increased water T2 values correlating with immune cell infiltration in the soleus and gastrocnemius muscles, while assessment of motor activity revealed only ...
Nicolina Südkamp, Marlena Rohm, Gabriele Russo, Xavier Helluy, Abdulhadi Kocabas, Martijn Froeling, Felix Kleefeld, Denise Manahan‐Vaughan, Tobias Ruck, Frank Jacobsen, Matthias Vorgerd, Johannes Forsting, Lara Schlaffke   +12 more
wiley   +1 more source

A POMT2 missense substitution contributes to hypoxia adaptation in hibernating mammals. [PDF]

Mol Biol Evol
Zhang J, Zhang X, Liu N, Hu J, Hiller M, Sharma V, Han F, Dai H, Tu X, Cooper DN, Wu DD, Zeng L.   +11 more
europepmc   +1 more source