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HBV production in transgenic mice
Gastroenterologia Japonica, 1990We produced transgenic mice by microinjecting a partially duplicated copies of hepatitis B virus (HBV) gene into fertilized eggs of C57BL/6 mice. One mouse was a high producer of HBV surface antigen (HBsAg) and HBV e antigen (HBeAg) in the serum. All offspring carrying HBV DNA were positive for both antigens in the serum.
K, Yamamura +5 more
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Insertional mutagenesis in transgenic mice
Transgenic Research, 1994Increasing numbers of transgenic mouse lines have resulted in several dozens of mutants created by insertional mutagenesis. The advantages of different vector systems and the problems associated with the analysis of mutations and the cloning of the affected genes are discussed in this review.
T, Rijkers, A, Peetz, U, Rüther
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Histological Examination of Transgenic Mice
2003Histological examination is important to detect and differentiate among different types of tissue changes at the microscopic level. An enlarged organ can be hyperplastic, hypertrophied, or neoplastic. It can also be merely inflamed or infected. Only a histological examination can differentiate among the various growth disturbances and pathological ...
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Transgenic RNA Interference in Mice
2008RNA interference (RNAi) is a powerful tool in deciphering gene function. It has been used extensively, especially in cultured mammalian cells. We have shown that RNAi-induced gene silencing can be generated in mice. With conventional transgenic techniques, shRNA-expressing constructs can be introduced into one-cell mouse embryos. The transgenic animals
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Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1988
S J, Compere, P, Baldacci, R, Jaenisch
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S J, Compere, P, Baldacci, R, Jaenisch
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Postmortem Examination of Transgenic Mice
2003Postmortem examination of transgenic animals should ideally be performed by or with the help of a trained pathologist. This is because although the steps in the examination can be manually performed by anyone, the interpretation of the findings can only be done with the knowledge of veterinary medicine.
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Pathogenesis of SARS-CoV-2 in Transgenic Mice Expressing Human Angiotensin-Converting Enzyme 2
Cell, 2020Ralph Barıç +2 more
exaly