Results 21 to 30 of about 2,313,243 (300)

Approaches for timeline reductions in pathogenesis studies using genetically modified mice

Microbiology Spectrum, 2023
Although genetically modified mouse models have long been a powerful tool for microbiology research, the manipulation of the mouse genome is expensive, time consuming, and has historically remained the domain of dedicated animal facilities.
Samantha Skavicus, Nicholas S. Heaton
doaj   +1 more source

SIRT1 Is Necessary for Proficient Telomere Elongation and Genomic Stability of Induced Pluripotent Stem Cells

Stem Cell Reports, 2014
The NAD-dependent deacetylase SIRT1 is involved in chromatin silencing and genome stability. Elevated SIRT1 levels in embryonic stem cells also suggest a role for SIRT1 in pluripotency.
Maria Luigia De Bonis, Sagrario Ortega, Maria A. Blasco   +2 more
doaj   +1 more source

A knockin mouse model for human ATP4aR703C mutation identified in familial gastric neuroendocrine tumors recapitulates the premalignant condition of the human disease and suggests new therapeutic strategies

Disease Models & Mechanisms, 2016
By whole exome sequencing, we recently identified a missense mutation (p.R703C) in the human ATP4a gene, which encodes the proton pump responsible for gastric acidification.
Oriol Calvete, Andrea Varro, D. Mark Pritchard, Alicia Barroso, Marta Oteo, Miguel Ángel Morcillo, Pierfrancesco Vargiu, Steven Dodd, Miriam Garcia, José Reyes, Sagrario Ortega, Javier Benitez   +11 more
doaj   +1 more source

Comparison of mouse species in an in vivo sars-cov-2 challenge model [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2023
The K18-hACE2 transgenic mice, a model animal having human ACE receptors, is employed in studies against the SARS-CoV-2 virus all over the world. Aged Balb/C mice utilized during the SARS-CoV outbreak were compared to non-T-cell, immunosuppressive Nude ...
Hivda ULBEGI POLAT
doaj   +1 more source

Non-selective calcium channel blocker bepridil decreases secondary pathology in mice after photothrombotic cortical lesion. [PDF]

PLoS ONE, 2013
Experimental studies have identified a complex link between neurodegeneration, β-amyloid (Aβ) and calcium homeostasis. Here we asked whether early phase β-amyloid pathology in transgenic hAPPSL mice exaggerates the ischemic lesion and remote secondary ...
Anu Lipsanen, Stefanie Flunkert, Kristina Kuptsova, Mikko Hiltunen, Manfred Windisch, Birgit Hutter-Paier, Jukka Jolkkonen   +6 more
doaj   +1 more source

Middle East Respiratory Syndrome Coronavirus Causes Multiple Organ Damage and Lethal Disease in Mice Transgenic for Human Dipeptidyl Peptidase 4

Journal of Infectious Diseases, 2015
Middle East respiratory syndrome coronavirus (MERS-CoV) causes life-threatening disease. Dipeptidyl peptidase 4 (DPP4) is the receptor for cell binding and entry.
Kun Li, C. Wohlford-Lenane, S. Perlman, Jincun Zhao, Alexander K Jewell, Leah R Reznikov, K. Gibson-Corley, D. Meyerholz, P. McCray   +8 more
semanticscholar   +1 more source

Cthrc1 is a positive regulator of osteoblastic bone formation. [PDF]

PLoS ONE, 2008
Bone mass is maintained by continuous remodeling through repeated cycles of bone resorption by osteoclasts and bone formation by osteoblasts. This remodeling process is regulated by many systemic and local factors.We identified collagen triple helix ...
Hiroaki Kimura, Kin Ming Kwan, Zhaoping Zhang, Jian Min Deng, Bryant G Darnay, Richard R Behringer, Takashi Nakamura, Benoit de Crombrugghe, Haruhiko Akiyama   +8 more
doaj   +1 more source

Mice Transgenic for Baff Develop Lymphocytic Disorders along with Autoimmune Manifestations

Journal of Experimental Medicine, 1999
The cause of many autoimmune and inflammatory diseases is unresolved, although dysregulated production of tumor necrosis factor (TNF) family members appears to be important in many cases.
F. Mackay, Stephen A. Woodcock, P. Lawton, C. Ambrose, M. Baetscher, P. Schneider, J. Tschopp, J. Browning   +7 more
semanticscholar   +1 more source

Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation

Journal of Neuroscience, 2006
Mutations in the genes for amyloid precursor protein (APP) and presenilins (PS1, PS2) increase production of β-amyloid 42 (Aβ42) and cause familial Alzheimer's disease (FAD).
Holly Oakley, Sarah L. Cole, Sreemathi Logan, Erika Maus, Peizhen Shao, J. Craft, Angela L. Guillozet-Bongaarts, M. Ohno, J. Disterhoft, L. V. Van Eldik, R. Berry, R. Vassar   +11 more
semanticscholar   +1 more source

Retinal analysis of a mouse model of Alzheimer's disease with multi-contrast optical coherence tomography [PDF]

Neurophotonics 7.1 (2020): 015006, 2019
Recent Alzheimer's disease (AD) patient studies have focused on retinal analysis, as the retina is the only part of the central nervous system which can be imaged non-invasively by optical methods. However as this is a relatively new approach, the occurrence and role of pathological features such as retinal layer thinning, extracellular amyloid beta (A$
arxiv   +1 more source