Results 21 to 30 of about 3,675,695 (304)

Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation

Journal of Neuroscience, 2006
Mutations in the genes for amyloid precursor protein (APP) and presenilins (PS1, PS2) increase production of β-amyloid 42 (Aβ42) and cause familial Alzheimer's disease (FAD).
Holly Oakley, Sarah L. Cole, Sreemathi Logan, Erika Maus, Peizhen Shao, J. Craft, Angela L. Guillozet-Bongaarts, M. Ohno, J. Disterhoft, L. V. Van Eldik, R. Berry, R. Vassar   +11 more
semanticscholar   +1 more source

Muscle hypertrophy in transgenic mice due to over-expression of porcine myostatin mutated at its cleavage site

Journal of Integrative Agriculture, 2016
Myostatin, a member of the transforming growth factor beta (TGF-β) superfamily, is a dominant inhibitor that acts to limit skeletal muscle growth and development.
Li-li QIAN, De-zun MA, Peng-fei GAO, Sheng-wang JIANG, Qing-qing WANG, Chun-bo CAI, Gao-jun XIAO, Xiao-rong AN, Wen-tao CUI   +8 more
doaj   +1 more source

Comparison of mouse species in an in vivo sars-cov-2 challenge model [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2023
The K18-hACE2 transgenic mice, a model animal having human ACE receptors, is employed in studies against the SARS-CoV-2 virus all over the world. Aged Balb/C mice utilized during the SARS-CoV outbreak were compared to non-T-cell, immunosuppressive Nude ...
Hivda ULBEGI POLAT
doaj   +1 more source

Middle East Respiratory Syndrome Coronavirus Causes Multiple Organ Damage and Lethal Disease in Mice Transgenic for Human Dipeptidyl Peptidase 4

Journal of Infectious Diseases, 2015
Middle East respiratory syndrome coronavirus (MERS-CoV) causes life-threatening disease. Dipeptidyl peptidase 4 (DPP4) is the receptor for cell binding and entry.
Kun Li, C. Wohlford-Lenane, S. Perlman, Jincun Zhao, Alexander K Jewell, Leah R Reznikov, K. Gibson-Corley, D. Meyerholz, P. McCray   +8 more
semanticscholar   +1 more source

MMI‐0100 Inhibits Cardiac Fibrosis in a Mouse Model Overexpressing Cardiac Myosin Binding Protein C

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundCardiac stress can trigger production of a 40‐kDa peptide fragment derived from the amino terminus of the cardiac myosin‐binding protein C.
Qinghang Meng, Bidur Bhandary, Hanna Osinska, Jeanne James, Na Xu, Kritton Shay‐Winkler, James Gulick, Monte S. Willis, Cynthia Lander, Jeffrey Robbins   +9 more
doaj   +1 more source

Aged wild-type and APP, PS1, and APP+PS1 mice present similar deficits in associative learning and synaptic plasticity independent of amyloid load

Neurobiology of Disease, 2008
Wild-type and single-transgenic (APP, PS1) and double-transgenic (APP+PS1) mice were studied at three different (3-, 12-, and 18-month-old) age periods.
A. Gruart, J.C. López-Ramos, M.D. Muñoz, J.M. Delgado-García   +3 more
doaj   +1 more source

Generation of Fad2 and Fad3 transgenic mice that produce n-6 and n-3 polyunsaturated fatty acids [PDF]

Open Biology, 2019
Linoleic acid (18 : 2, n-6) and α-linolenic acid (18 : 3, n-3) are polyunsaturated fatty acids (PUFAs), which are essential for mammalian health, development and growth.
Lishuang Song, Lei Yang, Jiapeng Wang, Xuefei Liu, Lige Bai, Anqi Di, Guangpeng Li   +6 more
doaj   +1 more source

Fecal microbiota transplantation alleviated Alzheimer’s disease-like pathogenesis in APP/PS1 transgenic mice

Translational Psychiatry, 2019
Alzheimer’s disease (AD) is the most common dementia in the elderly. Treatment for AD is still a difficult task in clinic. AD is associated with abnormal gut microbiota. However, little is known about the role of fecal microbiota transplantation (FMT) in
Jing Sun, Jingxuan Xu, Yi Ling, Fangyan Wang, Tianyu Gong, Changwei Yang, Shiqing Ye, Keyue Ye, Dianhui Wei, Ziqing Song, Danna Chen, Jiaming Liu   +11 more
semanticscholar   +1 more source

Application of transgenic mice to the molecular pathogenesis of cataract [PDF]

International Journal of Ophthalmology
One of the most prevalent disorders that cause blindness worldwide is cataract, and its essence is the visual disorder caused by the opacity of the lens. The significant degree of variation in cataracts and the fact that a variety of factors can impact a
Yue Zhang, Xiao-Ya Chen, Yu-Zhu Hu, Xiao Zhang, Shun-Fei Zheng, Shan-Shan Hu   +5 more
doaj   +1 more source

Galanin overexpressing transgenic mice [PDF]

Neuropeptides, 2002
Galanin overexpressing transgenic mice (GAL-tg) were generated on two different promoters. Both lines of GAL-tg displayed high levels of galanin in the hippocampus and reduced sensitivity to seizures, as compared to their respective wildtype littermate controls (WT).
Bartfai, Tamas, Hohmann, John G., Steiner, Robert A., Xu, Zhi-Qing D., Xu, Xiao-Jun, Holmberg, Kristina, Blakeman, Karin H., Hokfelt, Tomas, Mufson, Elliott J., Crawley, Jacqueline N., Wiesenfeld-Hallin, Zsuzsanna, Teklemichael, Dawit N.   +11 more
openaire   +2 more sources