Results 21 to 30 of about 3,684,237 (327)

Passive immunotherapy against Aβ in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage [PDF]

, 2004
BACKGROUND: Anti-Aβ immunotherapy in transgenic mice reduces both diffuse and compact amyloid deposits, improves memory function and clears early-stage phospho-tau aggregates.
Freeman, Melissa J, Gordon, Marcia N, Morgan, Dave, Rojiani, Amyn, Rosenthal, Arnon, Subbarao, Sangeetha, Wilcock, Donna M   +6 more
core   +3 more sources

Mice Transgenic for Baff Develop Lymphocytic Disorders along with Autoimmune Manifestations

Journal of Experimental Medicine, 1999
The cause of many autoimmune and inflammatory diseases is unresolved, although dysregulated production of tumor necrosis factor (TNF) family members appears to be important in many cases.
F. Mackay, Stephen A. Woodcock, P. Lawton, C. Ambrose, M. Baetscher, P. Schneider, J. Tschopp, J. Browning   +7 more
semanticscholar   +1 more source

Cthrc1 is a positive regulator of osteoblastic bone formation. [PDF]

PLoS ONE, 2008
Bone mass is maintained by continuous remodeling through repeated cycles of bone resorption by osteoclasts and bone formation by osteoblasts. This remodeling process is regulated by many systemic and local factors.We identified collagen triple helix ...
Hiroaki Kimura, Kin Ming Kwan, Zhaoping Zhang, Jian Min Deng, Bryant G Darnay, Richard R Behringer, Takashi Nakamura, Benoit de Crombrugghe, Haruhiko Akiyama   +8 more
doaj   +1 more source

Comparison of mouse species in an in vivo sars-cov-2 challenge model [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2023
The K18-hACE2 transgenic mice, a model animal having human ACE receptors, is employed in studies against the SARS-CoV-2 virus all over the world. Aged Balb/C mice utilized during the SARS-CoV outbreak were compared to non-T-cell, immunosuppressive Nude ...
Hivda ULBEGI POLAT
doaj   +1 more source

Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation

Journal of Neuroscience, 2006
Mutations in the genes for amyloid precursor protein (APP) and presenilins (PS1, PS2) increase production of β-amyloid 42 (Aβ42) and cause familial Alzheimer's disease (FAD).
Holly Oakley, Sarah L. Cole, Sreemathi Logan, Erika Maus, Peizhen Shao, J. Craft, Angela L. Guillozet-Bongaarts, M. Ohno, J. Disterhoft, L. V. Van Eldik, R. Berry, R. Vassar   +11 more
semanticscholar   +1 more source

Muscle hypertrophy in transgenic mice due to over-expression of porcine myostatin mutated at its cleavage site

Journal of Integrative Agriculture, 2016
Myostatin, a member of the transforming growth factor beta (TGF-β) superfamily, is a dominant inhibitor that acts to limit skeletal muscle growth and development.
Li-li QIAN, De-zun MA, Peng-fei GAO, Sheng-wang JIANG, Qing-qing WANG, Chun-bo CAI, Gao-jun XIAO, Xiao-rong AN, Wen-tao CUI   +8 more
doaj   +1 more source

Downregulation of FGF Signaling by Spry4 Overexpression Leads to Shape Impairment, Enamel Irregularities, and Delayed Signaling Center Formation in the Mouse Molar. [PDF]

, 2019
FGF signaling plays a critical role in tooth development, and mutations in modulators of this pathway produce a number of striking phenotypes. However, many aspects of the role of the FGF pathway in regulating the morphological features and the mineral ...
Ahn, Youngwook, Charles, Cyril, Ganss, Bernhard, Jheon, Andrew, Klein, Ophir D, Krumlauf, Robb, Marangoni, Pauline, Seidel, Kerstin, Viriot, Laurent   +8 more
core   +1 more source

MMI‐0100 Inhibits Cardiac Fibrosis in a Mouse Model Overexpressing Cardiac Myosin Binding Protein C

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundCardiac stress can trigger production of a 40‐kDa peptide fragment derived from the amino terminus of the cardiac myosin‐binding protein C.
Qinghang Meng, Bidur Bhandary, Hanna Osinska, Jeanne James, Na Xu, Kritton Shay‐Winkler, James Gulick, Monte S. Willis, Cynthia Lander, Jeffrey Robbins   +9 more
doaj   +1 more source

Middle East Respiratory Syndrome Coronavirus Causes Multiple Organ Damage and Lethal Disease in Mice Transgenic for Human Dipeptidyl Peptidase 4

Journal of Infectious Diseases, 2015
Middle East respiratory syndrome coronavirus (MERS-CoV) causes life-threatening disease. Dipeptidyl peptidase 4 (DPP4) is the receptor for cell binding and entry.
Kun Li, C. Wohlford-Lenane, S. Perlman, Jincun Zhao, Alexander K Jewell, Leah R Reznikov, K. Gibson-Corley, D. Meyerholz, P. McCray   +8 more
semanticscholar   +1 more source

Aged wild-type and APP, PS1, and APP+PS1 mice present similar deficits in associative learning and synaptic plasticity independent of amyloid load

Neurobiology of Disease, 2008
Wild-type and single-transgenic (APP, PS1) and double-transgenic (APP+PS1) mice were studied at three different (3-, 12-, and 18-month-old) age periods.
A. Gruart, J.C. López-Ramos, M.D. Muñoz, J.M. Delgado-García   +3 more
doaj   +1 more source