Results 41 to 50 of about 1,759,640 (316)

Cellular, molecular and functional characterisation of YAC transgenic mouse models of Friedreich Ataxia [PDF]

, 2014
Copyright © 2014 Anjomani Virmouni et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author ...
Al-Mahdawi, S, Al-Mahdawi Sahar, Anjomani Virmouni Sara, Virmouni, SA, Sandi, C, Chiranjeevi S, Pook, MA, Sahar Al-Mahdawi, Chiranjeevi Sandi, Sandi Chiranjeevi, Chiranjeevi Sandi (283956), Sara Anjomani Virmouni, Mark A. Pook (126056), Pook Mark A., Mark A. Pook, Sara Anjomani Virmouni (627000), Mark A Pook, Sahar Al-Mahdawi (126054)   +17 more
core   +1 more source

Human apoE3 but not apoE4 rescues impaired astrocyte activation in apoE null mice

Neurobiology of Disease, 2003
The allele E4 of apolipoprotein E (apoE) is an important risk factor for Alzheimer’s disease (AD) and the chronic brain inflammation which is associated with AD is more pronounced in subjects who carry this allele.
Gal Ophir, Sigal Meilin, Margalit Efrati, Joab Chapman, Dimitri Karussis, Allen Roses, Daniel M Michaelson   +6 more
doaj   +1 more source

Production of transgenic mice

Folia Pharmacologica Japonica, 1994
Transgenic mice are very useful for analyzing the functions of a gene either at the tissue level or at the whole body level. Here we describe the production of transgenic mice by the microinjection of DNA into the pronuclei of fertilized mouse eggs.
openaire   +5 more sources

Alzheimer's disease-like alterations in peripheral cells from presenilin-1 transgenic mice

, 2006
Many cases of early-onset inherited Alzheimer's disease (AD) are caused by mutations in the presenilin-1 (PS1) gene. Expression of PS1 mutations in cell culture systems and in primary neurons from transgenic mice increases their vulnerability to cell ...
Czech, Christian, Schindowski, Katharina, Eckert, Anne, Leutner, Silke, Luckhaus, Christian, Touchet, Nathalie, Müller, Walter E.   +6 more
core   +1 more source

The changing role of cell culture in the generation of transgenic livestock [PDF]

, 1999
Transgenesis may allow the generation of farm animals with altered phenotype, animal models for research and animal bioreactors. Although such animals have been produced, the time and expense involved in generating transgenic livestock and then ...
Whitelaw, C B, Farini, E, Webster, J
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Function and mechanism of the human SOD2 gene in mice cerebral ischemia/ reperfusion injury [PDF]

Acta Cirúrgica Brasileira
Purpose: To investigate the neuroprotective effects of the SOD2 gene in cerebral ischemia reperfusion injury function and the underlying mechanisms in a mice model of middle cerebral artery ischemia reperfusion.
Xitong Yang, Guangming Wang
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Enhanced UV-Induced Skin Carcinogenesis in Transgenic Mice Overexpressing Proprotein Convertases

Neoplasia: An International Journal for Oncology Research, 2013
The proprotein convertases (PCs) furin and PACE4 process numerous substrates involved in tumor growth, invasion, and metastasis. We have previously shown that PCs increase the susceptibility to chemical skin carcinogenesis. Because of the human relevancy
Jian Fu, Daniel E. Bassi, Jirong Zhang, Tianyu Li, Kathy Q. Cai, Courtney Lyons Testa, Emmanuelle Nicolas, Andres J. Klein-Szanto   +7 more
doaj   +1 more source

Nerve terminal degeneration is independent of muscle fiber genotype in SOD1 mice. [PDF]

PLoS ONE, 2010
Motor neuron degeneration in SOD1(G93A) transgenic mice begins at the nerve terminal. Here we examine whether this degeneration depends on expression of mutant SOD1 in muscle fibers.Hindlimb muscles were transplanted between wild-type and SOD1(G93A ...
Dario I Carrasco, Edyta K Bichler, Kevin L Seburn, Martin J Pinter   +3 more
doaj   +1 more source