Journal of Integrative Agriculture, 2016 Myostatin, a member of the transforming growth factor beta (TGF-β) superfamily, is a dominant inhibitor that acts to limit skeletal muscle growth and development.
Li-li QIAN +8 more
doaj +1 more source
Expression of a neuroendocrine gene signature in gastric tumor cells from CEA 424-SV40 large T antigen-transgenic mice depends on SV40 large T antigen. [PDF]
, 2012 A large fraction of murine tumors induced by transgenic expression of SV40 large T antigen (SV40 TAg) exhibits a neuroendocrine phenotype. It is unclear whether SV40 TAg induces the neuroendocrine phenotype by preferential transformation of progenitor ...
Georg Enders (187983) +32 more
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MMI‐0100 Inhibits Cardiac Fibrosis in a Mouse Model Overexpressing Cardiac Myosin Binding Protein C
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017 BackgroundCardiac stress can trigger production of a 40‐kDa peptide fragment derived from the amino terminus of the cardiac myosin‐binding protein C.
Qinghang Meng +9 more
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Comparison of mouse species in an in vivo sars-cov-2 challenge model [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2023 The K18-hACE2 transgenic mice, a model animal having human ACE receptors, is employed in studies against the SARS-CoV-2 virus all over the world. Aged Balb/C mice utilized during the SARS-CoV outbreak were compared to non-T-cell, immunosuppressive Nude ...
Hivda ULBEGI POLAT
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Lymphoid hyperplasia and lymphoma in transgenic mice expressing the small non-coding RNA, EBER1 of Epstein-Barr virus [PDF]
, 2010 Background. Non-coding RNAs have critical functions in diverse biological processes, particularly in gene regulation. Viruses, like their host cells, employ such functional RNAs and the human cancer associated Epstein-Barr virus (EBV) is no exception ...
Tsimbouri Penelope M. +15 more
core +2 more sources
Mechanisms underlying the initiation of cerebral betaamyloidosis and neurofibrillary tau pathology : new insights form transgenic mice [PDF]
, 2006 Numerous neurodegenerative disorders result from the aggregation of proteins that misfold and accumulate as fibrillar amyloid deposits in selectively vulnerable regions of the central nervous system.
Bolmont, Tristan
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Neurobiology of Disease, 2008 Wild-type and single-transgenic (APP, PS1) and double-transgenic (APP+PS1) mice were studied at three different (3-, 12-, and 18-month-old) age periods.
A. Gruart +3 more
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Retinoblastoma in transgenic mice
Nature, 1990 Retinoblastoma, a malignancy of the eye occurring in young children, has been widely studied as a model for genetic predisposition to cancer. This disease is caused by mutations in both alleles of an anti-oncogene (the retinoblastoma gene, Rb) that inactivate or eliminate the Rb encoded protein, p105Rb (refs 1 and 2).
Windle, J.J. +6 more
openaire +3 more sources
Experimental approaches to study cerebral amyloidosis in a transgenic mouse model of Alzheimer's disease [PDF]
, 2004 Misfolding, aggregation and the accumulation of proteins in the brain are common characteristics of diverse age-related neurodegenerative diseases. Each of these neurodegenerative diseases is associated with abnormalities in the folding of a different
Meyer-Lühmann, Melanie
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Application of transgenic mice to the molecular pathogenesis of cataract [PDF]
International Journal of OphthalmologyOne of the most prevalent disorders that cause blindness worldwide is cataract, and its essence is the visual disorder caused by the opacity of the lens. The significant degree of variation in cataracts and the fact that a variety of factors can impact a
Yue Zhang +5 more
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