Results 41 to 50 of about 3,675,695 (304)

Characterization of Progressive Motor Deficits in Mice Transgenic for the Human Huntington’s Disease Mutation

Journal of Neuroscience, 1999
Transgenic mice expressing exon 1 of the human Huntington’s disease (HD) gene carrying a 141–157 CAG repeat (line R6/2) develop a progressive neurological phenotype with motor symptoms resembling those seen in HD. We have characterized the motor deficits
R. Carter, Lisa A Lione, T. Humby, L. Mangiarini, A. Mahal, G. Bates, S. Dunnett, A. Morton, J. Morton   +8 more
semanticscholar   +1 more source

KSHV Latency Locus Cooperates with Myc to Drive Lymphoma in Mice.

PLoS Pathogens, 2015
Kaposi sarcoma-associated herpesvirus (KSHV) has been linked to Kaposi sarcoma and B-cell malignancies. Mechanisms of KSHV-induced oncogenesis remain elusive, however, in part due to lack of reliable in vivo models.
Sang-Hoon Sin, Yongbaek Kim, Anthony Eason, Dirk P Dittmer   +3 more
doaj   +1 more source

Function of B cells expressing a human immunoglobulin M rheumatoid factor autoantibody in transgenic mice. [PDF]

, 1993
We have generated transgenic mice that express the immunoglobulin (Ig)M heavy chain and kappa light chain genes coding for a human IgM rheumatoid factor (RF), Les.
Carson, DA, Chen, PP, Jirik, FR, Kipps, TJ, Roudier, J, Tighe, H, Tucker, R   +6 more
core   +2 more sources

Human apoE3 but not apoE4 rescues impaired astrocyte activation in apoE null mice

Neurobiology of Disease, 2003
The allele E4 of apolipoprotein E (apoE) is an important risk factor for Alzheimer’s disease (AD) and the chronic brain inflammation which is associated with AD is more pronounced in subjects who carry this allele.
Gal Ophir, Sigal Meilin, Margalit Efrati, Joab Chapman, Dimitri Karussis, Allen Roses, Daniel M Michaelson   +6 more
doaj   +1 more source

Mutant Tau knock-in mice display frontotemporal dementia relevant behaviour and histopathology [PDF]

, 2016
Peer ...
Drever, Benjamin D., Koss, David J., Platt, Bettina, Plucinska, Kaja, Riedel, Gernot, Robinson, Lianne, Stoppelkamp, Sandra, Veselcic, Peter   +7 more
core   +3 more sources

A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing

Nature Neuroscience, 2012
Cell type–specific expression of optogenetic molecules allows temporally precise manipulation of targeted neuronal activity. Here we present a toolbox of four knock-in mouse lines engineered for strong, Cre-dependent expression of channelrhodopsins ChR2 ...
L. Madisen, Tianyi Mao, H. Koch, Jia-min Zhuo, A. Berényi, Shigeyoshi Fujisawa, Yun-Wei A. Hsu, Alfredo J. Garcia, Xuan Gu, S. Zanella, Jolene Kidney, Hong Gu, Yimei Mao, Bryan M. Hooks, E. Boyden, G. Buzsáki, J. Ramirez, Allan R. Jones, K. Svoboda, Xue Han, E. Turner, Hongkui Zeng   +21 more
semanticscholar   +1 more source

Production of transgenic mice

Folia Pharmacologica Japonica, 1994
Transgenic mice are very useful for analyzing the functions of a gene either at the tissue level or at the whole body level. Here we describe the production of transgenic mice by the microinjection of DNA into the pronuclei of fertilized mouse eggs.
openaire   +5 more sources

Retinoblastoma in transgenic mice

Nature, 1990
Retinoblastoma, a malignancy of the eye occurring in young children, has been widely studied as a model for genetic predisposition to cancer. This disease is caused by mutations in both alleles of an anti-oncogene (the retinoblastoma gene, Rb) that inactivate or eliminate the Rb encoded protein, p105Rb (refs 1 and 2).
Windle, J.J., Albert, D.M., O'Brien, J.M., Marcus, D.M., Disteche, Ch.M., Bernards, R.A., Mellon, P.L.   +6 more
openaire   +3 more sources

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Function and mechanism of the human SOD2 gene in mice cerebral ischemia/ reperfusion injury [PDF]

Acta Cirúrgica Brasileira
Purpose: To investigate the neuroprotective effects of the SOD2 gene in cerebral ischemia reperfusion injury function and the underlying mechanisms in a mice model of middle cerebral artery ischemia reperfusion.
Xitong Yang, Guangming Wang
doaj   +1 more source