Results 41 to 50 of about 3,684,237 (327)
Antioxidant properties of HDL in transgenic mice overexpressing human apolipoprotein A-II
Journal of Lipid Research, 2002 Transgenic mice overexpressing human apolipoprotein A-II (huapoA-II) display high VLDL and low HDL levels. To evaluate the antioxidant potential of huapoA-II enriched HDL, we measured the activities of paraoxonase (PON) and platelet-activating factor ...
Elisabeth Boisfer +6 more
doaj +1 more source
Journal of Neuroscience, 2000 Amyloid plaques are a neuropathological hallmark of Alzheimer's disease (AD), but their relationship to neurodegeneration and dementia remains controversial.
L. Mucke +9 more
semanticscholar +1 more source
Human apoE3 but not apoE4 rescues impaired astrocyte activation in apoE null mice
Neurobiology of Disease, 2003 The allele E4 of apolipoprotein E (apoE) is an important risk factor for Alzheimer’s disease (AD) and the chronic brain inflammation which is associated with AD is more pronounced in subjects who carry this allele.
Gal Ophir +6 more
doaj +1 more source
Journal of Neuroscience, 1999 Transgenic mice expressing exon 1 of the human Huntington’s disease (HD) gene carrying a 141–157 CAG repeat (line R6/2) develop a progressive neurological phenotype with motor symptoms resembling those seen in HD. We have characterized the motor deficits
R. Carter +8 more
semanticscholar +1 more source
KSHV Latency Locus Cooperates with Myc to Drive Lymphoma in Mice.
PLoS Pathogens, 2015 Kaposi sarcoma-associated herpesvirus (KSHV) has been linked to Kaposi sarcoma and B-cell malignancies. Mechanisms of KSHV-induced oncogenesis remain elusive, however, in part due to lack of reliable in vivo models.
Sang-Hoon Sin +3 more
doaj +1 more source
Function and mechanism of the human SOD2 gene in mice cerebral ischemia/ reperfusion injury [PDF]
Acta Cirúrgica BrasileiraPurpose: To investigate the neuroprotective effects of the SOD2 gene in cerebral ischemia reperfusion injury function and the underlying mechanisms in a mice model of middle cerebral artery ischemia reperfusion.
Xitong Yang, Guangming Wang
doaj +1 more source
TT2013 meeting report: the transgenic technology meeting visits Asia for the first time [PDF]
, 2013 The 11th Transgenic Technology meeting was held in Guangzhou, China on 25th–27th February 2013. Over 300 scientists and students from round the world gathered to hear the latest developments in the technologies underpinning the creation of transgenic and
Strathdee, D., Whitelaw, C.B.A.
core +3 more sources
Folia Pharmacologica Japonica, 1994 Transgenic mice are very useful for analyzing the functions of a gene either at the tissue level or at the whole body level. Here we describe the production of transgenic mice by the microinjection of DNA into the pronuclei of fertilized mouse eggs.
openaire +5 more sources
Retinoblastoma in transgenic mice
Nature, 1990 Retinoblastoma, a malignancy of the eye occurring in young children, has been widely studied as a model for genetic predisposition to cancer. This disease is caused by mutations in both alleles of an anti-oncogene (the retinoblastoma gene, Rb) that inactivate or eliminate the Rb encoded protein, p105Rb (refs 1 and 2).
Windle, J.J. +6 more
openaire +3 more sources
A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing
Nature Neuroscience, 2012 Cell type–specific expression of optogenetic molecules allows temporally precise manipulation of targeted neuronal activity. Here we present a toolbox of four knock-in mouse lines engineered for strong, Cre-dependent expression of channelrhodopsins ChR2 ...
L. Madisen +21 more
semanticscholar +1 more source