Results 41 to 50 of about 1,897,120 (285)

Novel and unscrutinized immune entities of the zebrafish gut

FEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil, Marine Mantel, Julia Soh, Serge Mostowy, Sylvia Brugman, Gilles Claude Vanwalleghem   +5 more
wiley   +1 more source

Function and mechanism of the human SOD2 gene in mice cerebral ischemia/ reperfusion injury [PDF]

Acta Cirúrgica Brasileira
Purpose: To investigate the neuroprotective effects of the SOD2 gene in cerebral ischemia reperfusion injury function and the underlying mechanisms in a mice model of middle cerebral artery ischemia reperfusion.
Xitong Yang, Guangming Wang
doaj   +1 more source

Spotaneous Melanocytosis in Transgenic Mice

Journal of Investigative Dermatology, 1996
Clone B is a 2-kb fragment of cloned genomic DNA involved in adipocyte differentiation in vitro. Insertion of this DNA fragment into the genome of a variety of cell lines results in committing the recipient cells to undergo adipocyte differentiation.
William J. Wetzel, Suzie Chen, Hua Zhu, Martin A. Philbert   +3 more
openaire   +3 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Enhanced UV-Induced Skin Carcinogenesis in Transgenic Mice Overexpressing Proprotein Convertases

Neoplasia: An International Journal for Oncology Research, 2013
The proprotein convertases (PCs) furin and PACE4 process numerous substrates involved in tumor growth, invasion, and metastasis. We have previously shown that PCs increase the susceptibility to chemical skin carcinogenesis. Because of the human relevancy
Jian Fu, Daniel E. Bassi, Jirong Zhang, Tianyu Li, Kathy Q. Cai, Courtney Lyons Testa, Emmanuelle Nicolas, Andres J. Klein-Szanto   +7 more
doaj   +1 more source

Nerve terminal degeneration is independent of muscle fiber genotype in SOD1 mice. [PDF]

PLoS ONE, 2010
Motor neuron degeneration in SOD1(G93A) transgenic mice begins at the nerve terminal. Here we examine whether this degeneration depends on expression of mutant SOD1 in muscle fibers.Hindlimb muscles were transplanted between wild-type and SOD1(G93A ...
Dario I Carrasco, Edyta K Bichler, Kevin L Seburn, Martin J Pinter   +3 more
doaj   +1 more source

Transgenic Mice for cGMP Imaging [PDF]

Circulation Research, 2013
Rationale: Cyclic GMP (cGMP) is an important intracellular signaling molecule in the cardiovascular system, but its spatiotemporal dynamics in vivo is largely unknown. Objective: To generate and characterize ...
Angelos Vachaviolos, Michael Russwurm, Lai Wen, Thomas Ott, Susanne Feil, Matthias Hillenbrand, Rakesh K. Jain, Robert Feil, Martin Thunemann, Xiaoxing Han, Dai Fukumura, Cor de Wit   +11 more
openaire   +4 more sources

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Adipose-selective overexpression of ABHD5/CGI-58 does not increase lipolysis or protect against diet-induced obesity

Journal of Lipid Research, 2011
Adipose triglyceride lipase (ATGL) catalyzes the first step of triacylglycerol hydrolysis in adipocytes. Abhydrolase domain 5 (ABHD5) increases ATGL activity by an unknown mechanism.
Jorge M. Caviglia, Jenna L. Betters, Dianne-Helerie Dapito, Caleb C. Lord, Sean Sullivan, Streamson Chua, Terry Yin, Anna Sekowski, Haiyan Mu, Lawrence Shapiro, J. Mark Brown, Dawn L. Brasaemle   +11 more
doaj   +1 more source

Human Apolipoprotein B Transgenic Mice Generated with 207- and 145-Kilobase Pair Bacterial Artificial Chromosomes. Evidence that a distant 5'-element confers appropriate transgene expression in the intestine [PDF]

, 1997
We reported previously that ~80-kilobase pair (kb) P1 bacteriophage clones spanning either the human or mouse apoB gene (clones p158 and p649, respectively) confer apoB expression in the liver of transgenic mice, but not in the intestine. We hypothesized
Gunn, Michael D., McCormick, Sally P. A., Nielsen, Lars B., Pierotti, Vincenzo, Shizuya, Hiroaki, Tam, Carmen, Young, Stephen G.   +6 more
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