Results 61 to 70 of about 2,313,243 (300)
A Genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology [PDF]
, 2015 We provide microarray data comparing genome-wide differential expression and pathology throughout life in four lines of "amyloid" transgenic mice (mutant human APP, PSEN1, or APP/PSEN1) and "TAU" transgenic mice (mutant human MAPT gene).
Ali, SS +17 more
core
miRNA‐29 regulates epidermal and mesenchymal functions in skin repair
FEBS Letters, EarlyView.miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan +10 more
wiley +1 more source
Generation of H11-albumin-rtTA Transgenic Mice: A Tool for Inducible Gene Expression in the Liver
G3: Genes, Genomes, Genetics, 2019 The modification of the mouse genome by site-specific gene insertion of transgenes and other genetic elements allows the study of gene function in different developmental stages and in the pathogenesis of diseases.
Yu-Shan Li +9 more
doaj +1 more source
Resting state FMRI reveals diminished functional connectivity in a mouse model of amyloidosis. [PDF]
PLoS ONE, 2013 Functional connectivity (FC) studies have gained immense popularity in the evaluation of several neurological disorders, such as Alzheimer's disease (AD). AD is a complex disorder, characterised by several pathological features.
Disha Shah +8 more
doaj +1 more source
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Treatment of Alzheimer's Disease with Anti-Homocysteic acid Antibody [PDF]
, 2008 Homocysteic acid (HA) may play an important role in Alzhiemer disease (AD) as we previously reported that HA induced accumulation of intraneuronal A[beta]42. In this study, we first analyzed HA levels in a mouse model of AD.
Frank M. LaFerla +3 more
core +3 more sources
Interplay of integrins and selectins in metastasis
Molecular Oncology, EarlyView.Here we review the role of integrins and their interplay with selectins in metastasis. The efficacy of integrin‐targeted therapies may be reduced in tumors where metastasis relies heavily on selectins. In certain tumors, integrins and selectins exhibit a synergistic interaction during intraperitoneal dissemination.
Diana Maltseva +2 more
wiley +1 more source
Neuronal control of locomotor handedness in Drosophila [PDF]
, 2014 Handedness in humans - better performance using either the left or right hand - is personally familiar, moderately heritable, and regulated by many genes, including those involved in general body symmetry. But behavioral handedness, i.e. lateralization, is a multifaceted phenomenon.
arxiv +1 more source
MICE: The International Muon Ionization Cooling Experiment [PDF]
AIPConf.Proc.821:427-431,2006, 2006 Ionization cooling of a muon beam is a key technique for a Neutrino Factory or Muon Collider. An international collaboration is mounting an experiment to demonstrate muon ionization cooling at the Rutherford Appleton Laboratory. We aim to complete the experiment by 2010.
arxiv +1 more source
Molecular Oncology, EarlyView.Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen +12 more
wiley +1 more source