Results 151 to 160 of about 4,155,608 (362)
Impaired neurovascular coupling in the APPxPS1 mouse model of Alzheimerâs disease [PDF]
arXiv, 2019 The tight coupling between neuronal activity and the local increase of blood flow termed neurovascular coupling is essential for normal brain function. This mechanism of regulation is compromised in Alzheimer's Disease (AD). In order to determine whether a purely vascular dysfunction or a neuronal alteration of blood vessels diameter control could be ...
arxiv
KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells
Molecular Oncology, EarlyView.We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock +10 more
wiley +1 more source
A local cuisine tourism approach to authenticity and a sense of place for Postmodern gastronomy in I-SAN Thailand. [PDF]
African Journal of Hospitality, Tourism and Leisure, 2019 This study aims to study local cuisine culture in the Chiang Khan District of Loei Province in Northeastern Thailand by performing an examination and analysis through the use of external and internal environment analysis (SWOT Analysis) and by creating ...
Asst. Prof. Dr. Thirachaya Chaigasem +1 more
doaj
The same but different: impact of animal facility sanitary status on a transgenic mouse model of Alzheimer's disease [PDF]
arXivThe gut-brain axis has emerged as a key player in the regulation of brain function and cognitive health. Gut microbiota dysbiosis has been observed in preclinical models of Alzheimer's disease and patients. Manipulating the composition of the gut microbiota enhances or delays neuropathology and cognitive deficits in mouse models.
arxiv
A Study of the Fungistatic and Fungicidal Properties and of the Toxicity for Mice of Sodium Azide [PDF]
, 1944 James A. Herrick, J. E. Kempf
openalex +1 more source
Molecular Oncology, EarlyView.CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar +4 more
wiley +1 more source
Journal of Functional Foods, 2021 Obesity is a multifactorial disease with a genesis including the ingestion of hypercaloric diet rich in fat, ultra-processed food, poor in micronutrients and fiber. Some food rich in bioactive compounds are studies to prove their capacity to decrease the
F.P. Silva +13 more
doaj
Increase in Virulence of the Lansing Strain of Poliomyelitis Virus with Passage in Mice [PDF]
, 1951 John D. Ainslie
openalex +1 more source
Molecular Oncology, EarlyView.Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy +12 more
wiley +1 more source