Results 291 to 300 of about 4,772,082 (338)

Metabolic Consequences of Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Patients with rheumatoid arthritis (RA) may have metabolic disruption, which can contribute to adverse long‐term outcomes, for multiple reasons. Patients with RA appear to have a higher risk of sarcopenia, type 1 and type 2 diabetes mellitus, metabolic syndrome, and hypertension. Systemic inflammation in RA can cause a “lipid paradox,” with reduced low‐
Stevie Barry, Emily Sheng, Joshua F. Baker   +2 more
wiley   +1 more source

The Biological Characteristics and Mouse Model of Lassa Virus From the First Imported Case in China. [PDF]

MedComm (2020)
Zhou Y, Wang J, Cao R, Yang Y, Feng Y, Tang C, Yang H, Huang Q, Yu W, Wang H, Shi J, Ding K, Yuan L, Dai Q, Zhao X, Li H, Yang M, Luo F, Zhu F, Zhang Y, Wu D, Yang X, Lu S, Sun Q, Zhang L, Wang Y.   +25 more
europepmc   +1 more source

LOXHD1 and RHOB Expression by Monocytes Predicts Progressive Systemic Sclerosis associated Interstitial Lung Disease

Arthritis Care &Research, Accepted Article.
Objective A leading cause of death among scleroderma (SSc) patients, interstitial lung disease (ILD) remains challenging to prognosticate. The discovery of biomarkers that accurately determine which patients would benefit from close monitoring and aggressive therapy would be an essential clinical tool.
Cristina M Padilla, Robert Lafyatis, Kevin F Gibson, Christina Morse, Eleanor Valenzi, Xiaoping Chen, Xiaoyun Li, Yanwu Zhao, Yongseok Park, Dana Ascherman, Jonathan Minden, Robyn Domsic, Yingze Zhang, Daniel J Kass   +13 more
wiley   +1 more source

SERBP1-PCIF1 complex-controlled m6Am modification in glutamatergic neurons of the primary somatosensory cortex is required for neuropathic pain in mice. [PDF]

Nat Commun
Huang Y, Ma G, Xie S, Wei R, Liu Y, Zeng Y, Zhao Y, Wang Q, Yang L, Huang H, Hao L, Zhao X, Wang H, Shen W, Wong SSC, Cao JL, Tao YX, Pan ZQ.   +17 more
europepmc   +1 more source

Activation of NF‐κB Signaling by Optogenetic Clustering of IKKα and β

Advanced Biology, EarlyView.
This study presents an optogenetic approach for graded clustering of eGFP‐fused proteins using an eGFP‐specific nanobody and engineered Cryptochrome 2 variants. The method enables potent, reversible activation of NF‐κB signaling via endogenous pathways, as confirmed by RNA sequencing. This versatile system provides a spatially and temporally controlled
Alexandra Anna Maria Fischer, Markus Michael Kramer, Miguel Baños, Merlin Moritz Grimm, Manfred Fliegauf, Bodo Grimbacher, Gerald Radziwill, Sven Rahmann, Wilfried Weber   +8 more
wiley   +1 more source

Hyperuricemia in ob/ob mice relates to hepatocellular pyruvate metabolism/ xanthine oxidase axis. [PDF]

PLoS One
Zhang S, Hu S, Tan H, Jia E.
europepmc   +1 more source

Subsecond Analysis of Locomotor Activity in Parkinsonian Mice. [PDF]

eNeuro
Berezhnoi D, Chehade HD, Simms G, Chen L, Narasimhan KKS, Dravid SM, Chu HY.   +6 more
europepmc   +1 more source

Partial FAM19A5 deficiency in mice leads to disrupted spine maturation, hyperactivity, and an altered fear response. [PDF]

PLoS One
Shahapal A, Park S, Yoo S, Ma SX, Lee J, Kwak H, Hwang JI, Seong JY.   +7 more
europepmc   +1 more source