Advanced Biology, EarlyView.In this article, the establishment and characterization of a self‐assembled 3D BBB spheroid model using human induced pluripotent stem cell (hiPSC)‐derived and primary cells is reported. Spheroids demonstrate in‐vivo like tight junction ultrastructure and, in comparison to 2D mono‐cultures, higher transcript expression of BBB specific genes.
Sanjana Mathew‐Schmitt +10 more
wiley +1 more source
Transient receptor potential vanilloid 4 blockage attenuates pyroptosis in hippocampus of mice following pilocarpine‑induced status epilepticus. [PDF]
Acta Neuropathol CommunLiu L +8 more
europepmc +1 more source
Preventive Effect of Metformin in Radiation‐Induced Xerostomia
Advanced Biology, EarlyView.Head and neck cancer patients who received radiotherapy complain of severe dry mouth due to damage to the salivary glands. Metformin is an antidiabetic drug, but its radio‐protective effect has been reported. It is confirmed that metformin protects the salivary glands from radiation and provides evidence for the use of metformin in cancer treatment in ...
Sungryeal Kim +5 more
wiley +1 more source
Shared early molecular mechanisms revealed in P301S and 5xFAD Alzheimer's disease mouse models. [PDF]
Transl PsychiatrySuloh H +9 more
europepmc +1 more source
Depletion of TP53 in Human Pluripotent Stem Cells Triggers Malignant‐Like Behavior
Advanced Biology, EarlyView.Human pluripotent stem cells (hPSCs) with TP53‐depleting mutations are generated, mimicking commonly occurring events in vitro. Loss of TP53 does not alter pluripotency status or in vitro differentiation potential but causes genetic instability and transcriptome changes and confers superior clonal and anchorage‐free growth and higher chemotherapeutic ...
Joaquin Montilla‐Rojo +9 more
wiley +1 more source
Muscle-Derived miR-200a-3p Through Light-Intensity Exercise May Contribute to Improve Memory Dysfunction in Type 2 Diabetic Mice. [PDF]
FASEB JShima T, Onishi H, Terashima C.
europepmc +1 more source
Current and Future Cornea Chip Models for Advancing Ophthalmic Research and Therapeutics
Advanced Biology, EarlyView.This review analyzes cornea chip technology as an innovative solution to corneal blindness and tissue scarcity. The examination encompasses recent developments in biomaterial design and fabrication methods replicating corneal architecture, highlighting applications in drug screening and disease modeling while addressing key challenges in mimicking ...
Minju Kim +3 more
wiley +1 more source
Cytoplasmic expression of trans-active response DNA-binding protein-43 in aged mice display hippocampal sclerosis-like degeneration and neuronal loss with reduced lifespan. [PDF]
J Neuropathol Exp NeurolAnderson AJ +11 more
europepmc +1 more source
Advanced Biology, EarlyView.Hypoxia promotes the epithelial‐mesenchymal transition (EMT) of renal tubular epithelial cells via the SIRT1‐FoxO1‐FoxO3‐autophagy pathway, thereby resulting in the fibrosis of renal tubular epithelial cells. Activation of SIRT1 or induction of autophagy inhibits this process, alleviating hypoxia‐induced fibrosis.
Guangyu Wang +6 more
wiley +1 more source