Results 31 to 40 of about 4,772,082 (338)

Of mice and sperm [PDF]

open access: yesProceedings of the National Academy of Sciences, 2006
When females are sexually promiscuous, the ejaculates of different males may compete for the fertilization of a set of ova, a process known as sperm competition. In internally fertilizing species, potential for sperm competition occurs whenever the ejaculates of different males cooccur in the female reproductive tract at the time of ovulation.
openaire   +3 more sources

Neonatal ketone body elevation regulates postnatal heart development by promoting cardiomyocyte mitochondrial maturation and metabolic reprogramming

open access: yesCell Discovery, 2022
Neonatal heart undergoes metabolic conversion and cell cycle arrest preparing for the increased workload during adulthood. Herein, we report that neonatal ketone body elevation is a critical regulatory factor for postnatal heart development.
Danyang Chong   +16 more
doaj   +1 more source

Increased risk for T cell autoreactivity to ß-cell antigens in the mice expressing the Avy obesity-associated gene. [PDF]

open access: yes, 2019
There has been considerable debate as to whether obesity can act as an accelerator of type 1 diabetes (T1D). We assessed this possibility using transgenic mice (MIP-TF mice) whose ß-cells express enhanced green fluorescent protein (EGFP). Infecting these
Atkinson, Mark A   +6 more
core   +2 more sources

Evidence of a metabolic memory to early-life dietary restriction in male C57BL/6 mice [PDF]

open access: yes, 2012
<p>Background: Dietary restriction (DR) extends lifespan and induces beneficial metabolic effects in many animals. What is far less clear is whether animals retain a metabolic memory to previous DR exposure, that is, can early-life DR preserve ...
A Ceriello   +46 more
core   +1 more source

Highly Effective Ex Vivo Gene Manipulation to Study Kidney Development Using Self-Complementary Adenoassociated Viruses

open access: yesThe Scientific World Journal, 2014
Background. Ex vivo culture of intact embryonic kidney has become a powerful system for studying renal development. However, few methods have been available for gene manipulation and have impeded the identification and investigation of genes in this ...
Tie-Lin Chen   +7 more
doaj   +1 more source

A single meal has the potential to alter brain oxylipin content. [PDF]

open access: yes, 2020
Our objective was to determine whether consumption of a single meal has the potential to alter brain oxylipin content. We examined the cerebrum of mice fed a single high-fat/high-sucrose Western meal or a low-fat/low-sucrose control meal, as well as ...
Aung, HH   +5 more
core   +1 more source

Targeting mGlu5 metabotropic glutamate receptors in the treatment of cognitive dysfunction in a mouse model of phenylketonuria [PDF]

open access: yes, 2018
We studied group-I metabotropic glutamate (mGlu) receptors in Pah(enu2) (ENU2) mice, which mimic the genetics and neurobiology of human phenylketonuria (PKU), a metabolic disorder characterized, if untreated, by autism, and intellectual disability (ID ...
Battaglia, Giuseppe   +12 more
core   +2 more sources

Developmental Strategies of the Promotion Policies in Medical Tourism Industry in South Korea: A 10-Year Study (2009-2018)

open access: yesIranian Journal of Public Health, 2019
Background: After the revision of the Medical Service Act, Article 27-2, in 2009, Korea has been actively involved in the medical tourism industry. The number of foreign patients visiting Korea has consistently increased coming from various countries ...
Kyoung-Lee KIM, Byung-Ro SEO
doaj   +1 more source

SERPINB3 delays glomerulonephritis and attenuates the lupus-like disease in lupus murine models by inducing a more tolerogenic immune phenotype [PDF]

open access: yes, 2018
Objective: To explore the effects of SERPINB3 administration in murine lupus models with a focus on lupus-like nephritis. Methods: 40 NZB/W F1 mice were subdivided into 4 groups and intraperitoneally injected with recombinant SERPINB3 (7.5 \u3bcg/0.1 mL ...
Beggio, M   +12 more
core   +2 more sources

Age-related changes to macrophages are detrimental to fracture healing in mice. [PDF]

open access: yes, 2020
The elderly population suffers from higher rates of complications during fracture healing that result in increased morbidity and mortality. Inflammatory dysregulation is associated with increased age and is a contributing factor to the myriad of age ...
Brazina, Sloane   +8 more
core   +2 more sources

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