Results 121 to 130 of about 49,273 (237)
Evaluating the Impact of Intestinal Bile Salts on Drug Absorption Using PBPK Modeling: Case Studies With Efavirenz, Cinnarizine, and Posaconazole. [PDF]
CPT Pharmacometrics Syst PharmacolAl-Amiry Santos LG, Polak S, Yeo KR.
europepmc +1 more source
The Effect of Silk on the Stabilization of Labile Enzyme Lipoxygenase
Advanced NanoBiomed Research, EarlyView.Entrapping lipoxygenase within silk significantly extended its stability from under 24 h to 10 days. Variations in silk molecular weight and freeze‐drying conditions influenced silk properties and enzyme interactions. This stabilization is leveraged to develop a linoleic acid electrochemical biosensor, integrating lipoxygenase with horseradish ...
Jacopo Giaretta +7 more
wiley +1 more source
Dissipatively Fueled Unidirectionally Communicating DNA Circuits That Control Biocatalysis
Angewandte Chemie, EarlyView.Unidirectionally communicating, out‐of‐equilibrium DNA circuits are used to control enzyme activity. Transient DNAzyme activation generates fuel for temporal trypsin activation. Cyclic fuel‐driven hybridization and exonuclease‐mediated reset enable precise control over lifetimes, which is analyzed using combined experimental and computational ...
Philippe Jung +6 more
wiley +2 more sources
Antitumor Evaluation of Rhenium-188 and Paclitaxel Co-Delivered via Thermosensitive Hydrogel in a Hepatocellular Carcinoma Animal Model. [PDF]
Int J Mol SciShih YH, Peng CL, Chiang PF, Chen CT.
europepmc +1 more source
Advanced NanoBiomed Research, EarlyView.This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari +5 more
wiley +1 more source
Angewandte Chemie, EarlyView.This study explores the origins of life by linking prebiotic chemistry, the emergence of information‐carrying molecules such as RNA and proteins, and philosophical questions about consciousness. The study emphasizes the role of molecular evolution in the Central Dogma and provides insights into the chemical origins of biology and the basis of life's ...
Harald Schwalbe +5 more
wiley +2 more sources
Self-Assembly and Gelation Behavior of Methacrylated PEO-PPO-PEO Triblock Copolymer Pluronic F127. [PDF]
LangmuirBomediano MP +3 more
europepmc +1 more source
Polyphenol‐Based Biomaterials Against Cancer Radio/Chemotherapy‐Induced Intestinal Toxicity
Advanced NanoBiomed Research, EarlyView.Radiotherapy/chemotherapy often causes intestinal toxicity, impairing cancer patients’ quality of life and treatment efficacy. Polyphenols protect against this injury via multiple mechanisms, but face oral use limitations. This review outlines their protective mechanisms and delivery challenges, highlighting recent oral delivery advances and future ...
Jixu Lu +4 more
wiley +1 more source
Extended Fused Carbazole‐BODIPY, High Brightness NIR Organic Dyes
Angewandte Chemie, EarlyView.Highly fused boron‐dipyrromethene (BODIPY) with a strong donor group has been synthesized, and their photophysical behaviors fully characterized. They exhibit outstanding brightness for fluorophores emitting in the NIR region. Water‐soluble nanoparticles filled with one of these dyes demonstrate high efficiency as the NIR II visualization agent ...
Fabien Ceugniet +9 more
wiley +2 more sources