Results 21 to 30 of about 173,080 (297)

Polymicellar-based drug delivery systems for use in nanodentistry, oral and cranio-maxillo-facial oncology [PDF]

Biofunctional Materials, 2023
Polymer-based therapeutics is a precipitously-growing Research, Developmentand Innovation (R&D&I) translational field of bioengineering for biomedicine.
Ziyad S Haidar
doaj   +1 more source

Atomic Model and Micelle Dynamics of QS-21 Saponin

Molecules, 2014
QS-21 is a saponin extracted from Quillaja saponaria, widely investigated as a vaccine immunoadjuvant. However, QS-21 use is mainly limited by its chemical instability, significant variety in molecular composition and low tolerance dose in mammals. Also,
Conrado Pedebos, Laércio Pol-Fachin, Ramon Pons, Cilâine V. Teixeira, Hugo Verli   +4 more
doaj   +1 more source

Multipotent Poly(Tertiary Amine‐Oxide) Micelles for Efficient Cancer Drug Delivery

Advanced Science, 2022
The cancer drug delivery process involves a series of biological barriers, which require the nanomedicine to exhibit different, even opposite properties for high therapeutic efficacy.
Jiajia Xiang, Yihuai Shen, Yifan Zhang, Xin Liu, Quan Zhou, Zhuxian Zhou, Jianbin Tang, Shiqun Shao, Youqing Shen   +8 more
doaj   +1 more source

Novel polymer micelle mediated co-delivery of doxorubicin and P-glycoprotein siRNA for reversal of multidrug resistance and synergistic tumor therapy

Scientific Reports, 2016
Co-delivery of chemotherapeutics and siRNA with different mechanisms in a single system is a promising strategy for effective cancer therapy with synergistic effects.
Chun-ge Zhang, Wen-jing Zhu, Yang Liu, Z. Yuan, Shu-di Yang, Wei‐Liang Chen, Ji-zhao Li, Xiao-feng Zhou, Chun Liu, Xuenong Zhang   +9 more
semanticscholar   +1 more source

Bicomponent polymeric micelles for pH-controlled delivery of doxorubicin

Drug Delivery, 2020
Stimuli-responsive drug delivery systems (DDSs) are expected to realize site-specific drug release and kill cancer cells selectively. In this study, a pH-responsive micelle was designed utilizing the pH-sensitivity of borate bonds formed between dopamine
Chunyun Wang, Peilan Qi, Yan Lu, Lei Liu, Yanan Zhang, Qianli Sheng, Tianshun Wang, Mengying Zhang, Rui Wang, Shiyong Song   +9 more
doaj   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Exploring the Antioxidant Properties of Citrus limon (Lemon) Peel Ultrasound Extract after the Cloud Point Extraction Method

Biomass
Each year, a substantial amount of food is discarded around the globe. A significant portion of this waste consists of by-products derived from Citrus fruits such as lemons.
Vassilis Athanasiadis, Theodoros Chatzimitakos, Martha Mantiniotou, Eleni Bozinou, Stavros I. Lalas   +4 more
doaj   +1 more source

l-Carnitine conjugated chitosan-stearic acid polymeric micelles for improving the oral bioavailability of paclitaxel

Drug Delivery, 2020
A delivery system based on l-carnitine (LC) conjugated chitosan (CS)-stearic acid polymeric micelles has been developed for improving the oral bioavailability of paclitaxel (PTX) through targeting intestinal organic cation/carnitine transporter 2 (OCTN2).
Tan Yang, Jianfang Feng, Qian Zhang, Wei Wu, Hailan Mo, Lanzhen Huang, Wei Zhang   +6 more
doaj   +1 more source

Dasatinib self-assembled nanoparticles decorated with hyaluronic acid for targeted treatment of tumors to overcome multidrug resistance

Drug Delivery, 2021
Multidrug resistance (MDR) and lack of targeting specificity are the main reasons why traditional drug therapies fail and produce toxic side effects in cancer chemotherapy. In order to increase targeting specificity and maximize therapeutic efficacy, new
Yawen Zhang, Xiangle Zeng, Hairong Wang, Ranran Fan, Yike Hu, Xuejie Hu, Jianchun Li   +6 more
doaj   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source