Results 51 to 60 of about 2,728 (198)

Injectable Thermoresponsive Dual Nanocarrier Hydrogel for Local Tacrolimus Delivery with a Two-Phase Release Profile

Pharmaceutics
Background: Overexpression of immune cell populations leads to self-amplifying cytokine loops, contributing to chronic inflammation in both allograft rejection and autoimmune conditions.
Sanjida Ahmed Srishti, Paromita Paul Pinky, Diponkor Kumar Shill, Vidya Surti, Jelena M. Janjic   +4 more
doaj   +1 more source

Anti-Cancer Activity Based on the High Docetaxel Loaded Poly(2-Oxazoline)s Micelles

International Journal of Nanomedicine, 2021
Min Xu,1,2,* Chong Yao,3,* Wei Zhang,1 Shen Gao,1 Hao Zou,1 Jing Gao1,4 1School of Pharmacy, Second Military Medical University, Shanghai, 200433, People’s Republic of China; 2Department of Pharmacy, Changzheng Hospital, Shanghai, 200003, People ...
Xu M, Yao C, Zhang W, Gao S, Zou H, Gao J   +5 more
doaj  

Cholesterol absorption is mainly regulated by the jejunal and ileal ATP-binding cassette sterol efflux transporters Abcg5 and Abcg8 in mice1

Journal of Lipid Research, 2004
In the present study, we investigated whether intestinal sterol efflux transporters Abcg5 and Abcg8 play a major role in determining variations in cholesterol (Ch) absorption efficiency, and we compared the physiological functions of the duodenal ...
Li-Ping Duan, Helen H. Wang, David Q-H. Wang   +2 more
doaj   +1 more source

Molecular Dynamics‐Guided Sterol Engineering of mRNA‐Lipid Nanoparticles Reprograms Biodistribution and Enhances Spleen‐Selective Immunity

Advanced Science, EarlyView.
Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon, Seo‐Hyeon Bae, Jungyong Ji, Jisun Lee, Hosam Choi, Min‐Ho Kang, Sang‐In Park, Hyemin Kim, Nakyung Lee, Hajin Lee, Seonghoon Kim, Jungmin Kim, Subin Yoon, Seonghyun Lee, Seongje Cho, Dahyeon Ha, Ayoung Oh, Sohee Jo, Huijeong Choi, Yeeun Lee, Sowon Lee, Hyo‐Jung Park, Gitak Nam, Jisu Shin, Yujin Kang, Wonpil Im, Kiyoun Lee, Jae‐Hwan Nam   +27 more
wiley   +1 more source

Rational design and preclinical evaluation of elastin-like polypeptide micelle nanoparticles for drug delivery

Frontiers in Bioengineering and Biotechnology
Elastin-like polypeptide (ELP) micelle nanoparticles have emerged as versatile and tunable platforms for drug delivery across diseases. These bio-inspired and thermo-responsive polymers typically produced recombinantly in E.coli or yeast offer great ...
Abdulhakim Tofik, Yuwei Zhang, Cassandra Volpe, Jing Wang   +3 more
doaj   +1 more source

Regulating Droplet Dynamics via Wormlike Micelle Networks: From Splash Suppression to Precise Confined Spreading

Advanced Science, EarlyView.
As displayed in Graphical Abstract image.tif, a molecular‐design strategy precisely tailors high‐speed droplet dynamics through programmed surfactant co‐assembly. The structural transition into an entangled wormlike micelle network completely suppresses stochastic splashing on fibrous substrates.
Shuling Liu, Beibei Xie, Xingyue Lou, Yu Deng, Lei Wang, Jiawei Li, Dongming Qi   +6 more
wiley   +1 more source

Phytochemical-Based Nanoantioxidants Stabilized with Polyvinylpyrrolidone for Enhanced Antibacterial, Antioxidant, and Anti-Inflammatory Activities

Antioxidants
Despite the inhibitory effect of phytoncide (Pht) on food-borne pathogenic bacterial growth, the hydrophobic nature and susceptibility to biodegradation under physiological conditions limits its applications.
Hyeryeon Oh, Jin Sil Lee, Hyojung Park, Panmo Son, Byoung Seung Jeon, Sang Soo Lee, Daekyung Sung, Jong-Min Lim, Won Il Choi   +8 more
doaj   +1 more source

In Situ Programmable Modulation of Hydrogel Stiffness for Stage‐Adaptive Bone Regeneration

Advanced Science, EarlyView.
Near‐infrared (NIR) irradiation triggers Ca2+ release from thermoresponsive nanocarriers, enabling in situ stiffening of an adaptive hydrogel from a soft to a stiff state, thereby sequentially supporting mesenchymal stromal cell stemness and osteogenic differentiation for stage‐adaptive bone regeneration.
Yuxin Yang, Fan Yang, Lu Wang, Zongtai Li, Weichang Li, Xinchun Zhang   +5 more
wiley   +1 more source

Influence of Deep Eutectic Solvent Composition on Micelle Properties: A Molecular Dynamics Study

Molecules
This study investigates the structural and transport properties of SDS, CTAB, and SB3-12 micelles in three deep eutectic solvents (DESs), Ethaline, Glyceline, and Reline, using molecular dynamics (MD) simulations.
Iuliia V. Voroshylova, Elisabete S. C. Ferreira, M. Natália D. S. Cordeiro   +2 more
doaj   +1 more source

Retraction: Development and optimization of TPGS/P84 mixed polymeric micelles: enhanced stability and anticancer effect of paclitaxel against tumor therapy [PDF]

Acta Poloniae Pharmaceutica
Dear Editor, In our subsequent study after the receipt of the article, it was found that the P84Ms carrier had certain cytotoxicity. As can be seen from the Figure 1 and Figure 2, compared with the cells in the control group, after incubation with ...
Qi Huang, Yingli Zhao, Xing Fang, Jianjun Liu, Quan Xia, Chao Tan, Yao Peng, JingJing Wu   +7 more
doaj   +1 more source