Rational and Social Agency: The Philosophy of Michael Bratman
Journal of Social Ontology, 2015 Blomberg Olle
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Human papillomavirus integration transforms chromatin to drive oncogenesis [PDF]
Genome Biology, 2023 Background Human papillomavirus (HPV) drives almost all cervical cancers and up to 70% of head and neck cancers. Frequent integration into the host genome occurs predominantly in tumorigenic types of HPV. We hypothesize that changes in chromatin state at
Mehran Karimzadeh +5 more
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Sensitive and reproducible cell-free methylome quantification with synthetic spike-in controls [PDF]
Cell Reports: Methods, 2022 Summary: Cell-free methylated DNA immunoprecipitation sequencing (cfMeDIP-seq) identifies genomic regions with DNA methylation, using a protocol adapted to work with low-input DNA samples and with cell-free DNA (cfDNA).
Samantha L. Wilson +7 more
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Cell-free DNA methylation-defined prognostic subgroups in small-cell lung cancer identified by leukocyte methylation subtraction [PDF]
iScience, 2022 Summary: Small-cell lung cancer (SCLC) methylome is understudied. Here, we comprehensively profile SCLC using cell-free methylated DNA immunoprecipitation followed by sequencing (cfMeDIP-seq).
Sami Ul Haq +16 more
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The cell-free DNA methylome captures distinctions between localized and metastatic prostate tumors [PDF]
Nature Communications, 2022 Metastatic prostate cancer can be difficult to biopsy and characterise. Here, the authors use cell-free DNA methylation analysis to illustrate changes in hypermethylation in metastatic disease.
Sujun Chen +22 more
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Impact of Postoperative Neck Radiotherapy Volumes on Long-Term Unstimulated Saliva Flow Following Primary Surgery and Ipsilateral Neck Dissection for Oral Cavity Squamous Cell Carcinoma. [PDF]
Head NeckABSTRACT Background We investigate the association of postoperative radiotherapy (PORT) volumes and salivary function in oral cavity SCC (OSCC). Methods OSCC patients undergoing PORT 2005–2021 underwent modified Schirmer test (MST) pre‐PORT, 6 and/or 12 months post‐PORT. Hyposalivation rates were compared by PORT volumes.
Rooney CM +20 more
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Journal of Social Ontology, 2015 Michael Bratman’s work is established as one of the most important philosophical approaches to group agency so far, and Shared Agency, A Planning Theory of Acting Together confirms that impression.
Petersson Björn
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Clinical validation of a tissue-agnostic genome-wide methylome enrichment assay to monitor response to pembrolizumab [PDF]
npj Precision OncologyImmunotherapy has significantly improved the treatment of metastatic solid tumors; however, detecting early signs of response to enable timely intervention for resistant tumors remains challenging.
Eric Y. Stutheit-Zhao +25 more
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Computer-assisted image analysis of the tumor microenvironment on an oral tongue squamous cell carcinoma tissue microarray [PDF]
Clinical and Translational Radiation Oncology, 2019 Oral tongue squamous cell carcinoma (OTSCC) displays variable levels of immune cells within the tumor microenvironment. The quantity and localization of tumor infiltrating lymphocytes (TILs), specific functional TIL subsets (e.g., CD8+), and biomarker ...
Sangjune Laurence Lee +14 more
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Street trees provide an opportunity to mitigate urban heat and reduce risk of high heat exposure [PDF]
Scientific ReportsClimate change is exacerbating the need for urban greening and the associated environmental and human well-being benefits. Trees can help mitigate urban heat, but more detailed understanding of cooling effects of green infrastructure are needed to guide ...
Ailene K. Ettinger +8 more
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