Results 1 to 10 of about 2,342 (176)

Structures and functions of the MICOS: Pathogenesis and therapeutic implications in Alzheimer's disease [PDF]

Acta Pharmaceutica Sinica B
Mitochondrial dysfunction is a critical factor in the pathogenesis of Alzheimer's disease (AD). The mitochondrial contact site and cristae organizing system (MICOS) plays a pivotal role in shaping the inner mitochondrial membrane, forming cristae ...
Xinwen Zhang, Zhou Wu
exaly   +4 more sources

Emerging Roles of the MICOS Complex in Cristae Dynamics and Biogenesis

Biology, 2021
Mitochondria are double membrane-enclosed organelles performing important cellular and metabolic functions such as ATP generation, heme biogenesis, apoptosis, ROS production and calcium buffering.
Ruchika Anand, Andreas Reichert, Arun Kumar Kondadi   +2 more
exaly   +3 more sources

Mitochondrial contact site and cristae organizing system (MICOS) machinery supports heme biosynthesis by enabling optimal performance of ferrochelatase

Redox Biology, 2021
Heme is an essential cofactor required for a plethora of cellular processes in eukaryotes. In metazoans the heme biosynthetic pathway is typically partitioned between the cytosol and mitochondria, with the first and final steps taking place in the ...
Amy Medlock, Iryna Bohovych, Oleh Khalimonchuk   +2 more
exaly   +3 more sources

Glutamine metabolic stress induces SLC25A6-dependent mitofission via MIC60–MIC19 complex disassembly in colorectal cancer [PDF]

Cell Death and Disease
Glutamine addiction is a key metabolic vulnerability in cancer. However, the mechanisms governing the limited efficacy of glutamine metabolism inhibitor (GMI) monotherapy require further investigation.
Yinong Wang, Bingzhi Wang, Yu Liu, Cheng Zhou, Junhu Yuan, Fanyu Zhang, Ling Ma, Yiming Ma, Hongying Wang   +8 more
doaj   +2 more sources

Coordination of cytochrome bc 1 complex assembly at MICOS [PDF]

EMBO Reports
The boundary and cristae domains of the mitochondrial inner membrane are connected by crista junctions. Most cristae membrane proteins are nuclear-encoded and inserted by the mitochondrial protein import machinery into the inner boundary membrane.
Ralf M Zerbes, Lilia Colina-Tenorio, Maria Bohnert, Karina von der Malsburg, Christian D Peikert, Carola S Mehnert, Inge Perschil, Rhena F U Klar, Rinse de Boer, Anita Kram, Ida van der Klei, Silke Oeljeklaus, Bettina Warscheid, Heike Rampelt, Martin van der Laan   +14 more
doaj   +2 more sources

SLP2 and MIC13 synergistically coordinate MICOS assembly and crista junction formation [PDF]

iScience
Summary: The MICOS complex, essential for cristae organization, comprises MIC10 and MIC60 subcomplexes, with MIC13 as a crucial subunit. MIC13 mutations cause severe mitochondrial hepato-encephalopathy, cristae defects, and MIC10-subcomplex loss.
Ritam Naha, Rebecca Strohm, Yulia Schaumkessel, Jennifer Urbach, Ilka Wittig, Andreas S. Reichert, Arun Kumar Kondadi, Ruchika Anand   +7 more
doaj   +2 more sources

Mico humeralifer [PDF]

Mammalian Species, 2013
16. Santarém Marmoset Mico humeralifer French: Quistiti a camail / German: Weil 3schulter-Seidenaffchen / Spanish: Titi deSantarém Other common names: Black-and-white Tassel-ear Marmoset, Tassel-ear Marmoset Taxonomy. [acchus humeralifer E. Geoffroy Saint-Hilaire, 1812, Brazil. Restricted by P.
Russell A. Mittermeier, Anthony B. Rylands, Don E. Wilson   +2 more
openaire   +4 more sources

Protease OMA1 modulates mitochondrial bioenergetics and ultrastructure through dynamic association with MICOS complex

iScience, 2021
Summary: Remodeling of mitochondrial ultrastructure is a process that is critical for organelle physiology and apoptosis. Although the key players in this process—mitochondrial contact site and cristae junction organizing system (MICOS) and Optic Atrophy
Martonio Ponte Viana, Roman M. Levytskyy, Ruchika Anand, Andreas S. Reichert, Oleh Khalimonchuk   +4 more
doaj   +1 more source

Drosophila MICOS knockdown impairs mitochondrial structure and function and promotes mitophagy in muscle tissue

Biology Open, 2020
The mitochondrial contact site and cristae organizing system (MICOS) is a multi-protein interaction hub that helps define mitochondrial ultrastructure.
Li-jie Wang, Tian Hsu, Hsiang-ling Lin, Chi-yu Fu   +3 more
doaj   +1 more source

Detailed analysis of the human mitochondrial contact site complex indicate a hierarchy of subunits. [PDF]

PLoS ONE, 2015
Mitochondrial inner membrane folds into cristae, which significantly increase its surface and are important for mitochondrial function. The stability of cristae depends on the mitochondrial contact site (MICOS) complex.
Christine Ott, Eva Dorsch, Martin Fraunholz, Sebastian Straub, Vera Kozjak-Pavlovic   +4 more
doaj   +1 more source