Results 61 to 70 of about 315,425 (275)

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Demonstration of InGaN full-color monolithic micro-LED display using stacking and selective removal of the light-emitting layer

Applied Physics Express
A full-color monolithic micro-light-emitting diode (LED) display based on InGaN quantum wells is demonstrated. We stacked red, green, and blue (RGB) light-emitting layers and selectively removed and regrew a p-type layer to create distinct areas on a ...
Koichi Goshonoo, Koji Okuno, Masaki Ohya
doaj   +1 more source

CMOS-integrated GaN LED array for discrete power level stepping in visible light communications [PDF]

, 2017
We report a CMOS integrated micro-LED array capable of generating discrete optical output power levels. A 16 x 16 array of individually addressable pixels are on-off controlled through parallel logic signals. With carefully selected groups of LEDs driven
Dawson, Martin D., Griffiths, Alexander D., Gu, Erdan, Haas, Harald, Henderson, Robert, Herrnsdorf, Johannes, Islim, Mohamed Sufyan, McKendry, Jonathan J. D.   +7 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

A scalable optoelectronic neural probe architecture with self-diagnostic capability [PDF]

, 2018
There is a growing demand for the development of new types of implantable optoelectronics to support both basic neuroscience and optogenetic treatments for neurological disorders.
Degenaar, Patrick, Dong, Na, Maaskant, Pleun P., Soltan, Ahmed, Sun, Xiaohan, Zhao, Hubin   +5 more
core   +2 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Mini-LED and Micro-LED: Promising Candidates for the Next Generation Display Technology

Applied Sciences, 2018
Displays based on inorganic light-emitting diodes (LED) are considered as the most promising one among the display technologies for the next-generation.
Tingzhu Wu, Chin-Wei Sher, Yue Lin, Chun-Fu Lee, Shijie Liang, Yijun Lu, Sung-Wen Huang Chen, Weijie Guo, Hao-Chung Kuo, Zhong Chen   +9 more
doaj   +1 more source

Angular color shift of micro-LED displays

Optics Express, 2019
Sidewall emission of a micro-scale light emitting diode (micro-LED) improves the light extraction efficiency, but it causes mismatched angular distributions between AlGaInP-based red micro-LED and InGaN-based blue/green counterparts due to material difference. As a result, color shift of RGB micro-LED displays may become visually noticeable. To address
Fangwang Gou, En-Lin Hsiang, Guanjun Tan, Pei-Ting Chou, Yun-Li Li, Yi-Fen Lan, Shin-Tson Wu   +6 more
openaire   +2 more sources