Results 241 to 250 of about 9,291 (290)

Aniridia‐associated keratopathy: Clinical and molecular mechanisms of disease progression and emerging therapeutic targets

Acta Ophthalmologica, EarlyView.
Abstract Congenital aniridia is a rare genetic disorder primarily caused by pathogenic variants of the PAX6 gene. It leads to various panocular anomalies, including aniridia‐associated keratopathy (AAK). This review highlights recent insights into its pathogenesis, focusing on clinical staging, microstructural changes in the cornea and molecular ...
N. Szentmáry, S. Suiwal, M. Amini, F. N. Fries, A. Náray, L. Latta, Z. Li, S. Li, S. Liu, S. L. Hsu, S. Kundu, G. Tóth, S. Trusen, J. Zimmermann, B. Seitz, B. Käsmann‐Kellner, Z. Hoxha, A. Langenbucher, O. Stachs, M. Cortón‐Perez, K. Tory, A. Csorba, Z. Z. Nagy, M. C. Acosta, J. Gallar, M. Csidey, E. Maka, T. Stachon   +27 more
wiley   +1 more source

5‐HT2A receptor agonism by tert‐leucinamide and valinamide synthetic cannabinoids: In vitro and in vivo evidence

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose New synthetic cannabinoid receptor agonists (SCRAs) are associated with severe adverse effects, including unexpected psychiatric symptoms. These compounds are mainly active through their potent agonism on the cannabinoid receptors CB1 and CB2.
Giorgia Corli, Deborah Rudin, Dino Luethi, Matthias E. Liechti, Sabrine Bilel, Matteo Marti, Henrik Green, Manuela Carla Monti, Caitlyn Norman   +8 more
wiley   +1 more source

Inhibition of peripheral CB1 receptors modulates food intake and metabolic efficiency in obesity independently of the gut–brain vagal axis

British Journal of Pharmacology, EarlyView.
Background and Purpose Obesity involves profound disruptions in neuronal circuits, neuroendocrine communication and the endocannabinoid system. While global blockade of cannabinoid CB1 receptors improves metabolism, its clinical use is limited by neuropsychiatric side effects.
Oriane Onimus, Camille de Almeida, Benoit Bertrand, Julien Castel, Nejmeh Mashhour, Anthony Ansoult, Serge Luquet, Giuseppe Gangarossa   +7 more
wiley   +1 more source

The Role of Neuropeptide Y in Dental Pulp: Balancing Neurogenic Inflammation and Pain Modulation

International Endodontic Journal, EarlyView.
ABSTRACT Background Dental pulp is a densely innervated, low‐compliance tissue in which neurogenic inflammation can rapidly escalate into oedema, raised intrapulpal pressure, microvascular compromise, and pain. While Substance P (SP) and Calcitonin gene‐related peptide (CGRP) are well‐established drivers of pulp vasodilation, the Neuroopeptide Y (NPY ...
Javier Caviedes‐Bucheli, Esteban Ulate, Hugo‐Roberto Munoz, Nestor Ríos‐Osorio   +3 more
wiley   +1 more source

Clinical Study on the Efficacy of 35% Hydrogen Peroxide Gel According to Exposure Time (40 min vs. 20 min) by Spectrophotometry

Journal of Esthetic and Restorative Dentistry, EarlyView.
ABSTRACT Objective To analyze the chromatic effect on CIELAB coordinates and the clinical effectiveness of in‐office whitening treatment (perceptible changes) with 35% hydrogen peroxide (HP) gel according to the number of clinical sessions and exposure time (40 min vs. 20 min) in the three thirds of the tooth.
Trinidad Rincón, Maria Portillo Muñoz, Maria Lobato, Ana María Martín Casado, Laryssa Mylenna Madruga Barbosa, Alessandro Loguercio, Cristina Gómez‐Polo   +6 more
wiley   +1 more source

One‐Year Color Stability of a Reduced 37.5% Hydrogen Peroxide In‐Office Bleaching Protocol: A Randomized Clinical Trial

Journal of Esthetic and Restorative Dentistry, EarlyView.
ABSTRACT Objective This randomized clinical trial evaluated the one‐year color stability and patient satisfaction regarding dental esthetic improvement after 37.5% hydrogen peroxide (37.5HP) in‐office bleaching with a reduced application protocol. Materials and Methods Forty participants with a shade mean C2 or darker were randomly allocated into two ...
Mariana Evangelista Santos, Danielle Araújo Izídio Carvalho de Azevedo, Virgínia Feitosa Nogueira Rocha, Sônia Saeger Meireles   +3 more
wiley   +1 more source

Systematic Review Evaluating the Influence of Veneering Design on the Clinical Outcome of All‐Ceramic Implant‐Supported 3–4 Units and Full Arch Fixed Dental Prostheses

Journal of Esthetic and Restorative Dentistry, EarlyView.
ABSTRACT Objective To systematically assess survival, failure, and complication rates of all‐ceramic implant‐supported monolithic and micro‐veneered FDPs (i‐FDPs) in partially/completely edentulous patients compared to veneered restorations. Materials and Methods An electronic search identified prospective clinical studies on all‐ceramic i‐FDPs with at
Shaza Bishti, Stefan Wolfart, Marcel Zwahlen, Lukas Waltenberger   +3 more
wiley   +1 more source

Effect of margin thickness and cement gap on the fabrication and fit accuracy of additively manufactured crowns in definitive resins with different filler content

Journal of Prosthodontics, EarlyView.
Abstract Purpose To evaluate how commercially available composite resins in varying filler content affect the fabrication and fit accuracy (trueness and precision) of additively manufactured (AM) definitive crowns with different margin thickness and cement gaps by comparing them to subtractively manufactured (SM) polymer‐infiltrated ceramic crowns ...
Mustafa Borga Dönmez, Gülce Çakmak, Çiğdem Kahveci, Amir H. Nejat, Burak Yilmaz, Pinar Altinci   +5 more
wiley   +1 more source

Araguainha Dome, Brazil: A polygonal impact structure due to a complex pre‐impact regional structural framework

Meteoritics &Planetary Science, EarlyView.
Abstract We investigated the structural framework of the north–northwestern Paraná Basin in Brazil to test whether the pre‐impact structures in this region may have had any influence on the first‐order formation and morphostructure of the Araguainha impact structure (AIS).
Renato B. Bernardes, Wolf U. Reimold, Roger L. Gibson, Julia B. Curto Ma, Adolfo B. Silva, Natalia Hauser   +5 more
wiley   +1 more source

LifeMet: Report on the 2024–2025 meteorite recovery expedition in Dronning Maud Land, Antarctica for the study of microbe–meteorite interactions

Meteoritics &Planetary Science, EarlyView.
Abstract Since the discovery of nine meteorites near the Yamato mountains in 1969, Antarctica has been recognized as a superb location for meteorite recovery. While Antarctic recovery expeditions prioritize meteorite preservation for mineralogical and planetary studies, meteorites are not typically collected for biological applications.
Rachael Lappan, Rachel S. Kirby, Andrew G. Tomkins   +2 more
wiley   +1 more source