Results 41 to 50 of about 11,713 (257)
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
, 2017 The microscopic morphology of fatigue crack initiation and propagation behavior was investigated for B93пч high strength aluminum using optical microscopy, scanning electron microscopy and transmission electron microscopy.
Ou, Ling +4 more
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Effect of low temperature on fatigue and crack propagation behavior of aeronautic aluminium alloy
Journal of Aeronautical Materials, 2021 Fatigue and crack growth tests were performed on two categories of the common aeronautic aluminum- alloys 2524-T3 and 7050-T7451 at ambient temperature of 25 ℃ and cryogenic temperature of –70 ℃, in order to investigate the fatigue and crack propagation ...
LIU Mudong
doaj +1 more source
, 2013 Three different types of thermoplastics, poly(ether imide) (PEI), polycarbonate (PC), and poly(butylene terephthalate) (PBT) were used to modify epoxy for cryogenic applications.
Lee, Joong Hee +12 more
core +1 more source
Finite element analyses of mode I interlaminar delamination in z-fibre reinforced composite laminates. [PDF]
, 2003 This paper presents a detailed numerical study of the mode I interlaminar fracture of carbon/epoxy composite laminates with z-fibre reinforcement. The study was performed using a double cantilever beam configuration.
Marcello Grassi +3 more
core +1 more source
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
Micro-scale modelling of bovine cortical bone fracture: Analysis of crack propagation and microstructure using X-FEM [PDF]
, 2012 Bone-fracture susceptibility is increased by factors such as bone loss, microstructure changes, and variations in material properties. Therefore, investigation of the effect of microstructure and material properties of bone on crack propagation in it and
Silberschmidt, V.V. +8 more
core +1 more source
Micro & nanoDAC - A powerful technique for nondestructive microcrack evaluation
, 2022 S.194-198Recent advances in microelectronics and electronic packaging technology have led to a strong need in strain and stress analysis on micro and nano scale as well.
Vogel, D., Michel, B.
core +1 more source
Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina +11 more
wiley +1 more source