Results 121 to 130 of about 902,749 (382)

Comparison of RNA-Seq and Microarray in Transcriptome Profiling of Activated T Cells

PLoS ONE, 2014
To demonstrate the benefits of RNA-Seq over microarray in transcriptome profiling, both RNA-Seq and microarray analyses were performed on RNA samples from a human T cell activation experiment.
Shanrong Zhao, W. Fung-Leung, A. Bittner, K. Ngo, Xuejun Liu   +4 more
semanticscholar   +1 more source

Exosome Proteomics of SOD1D90A Mutation Suggest Early Disease Mechanisms, and FN1 as a Biomarker

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Amyotrophic lateral sclerosis (ALS) is a neuromuscular disease. Super oxide dismutase 1 (SOD1) gene mutations cause ALS, and the D90A mutation is associated with primarily upper motor neuron (UMN) loss. Objective Our goal is to reveal the early cellular events in ALS pathology and identify potential pharmacokinetic biomarkers, using well ...
Mukesh Gautam, Ali Laith, Aslihan Gunel, Melda Yilmaz, Nazli Basak, Halil Idrisoglu, P. Hande Ozdinler   +6 more
wiley   +1 more source

Identification of Potential Therapeutic Targets Against Anthrax-Toxin-Induced Liver and Heart Damage

Toxins
Anthrax represents a disease resulting from infection by toxin-secreting bacteria, Bacillus anthracis. This research aimed to identify new therapeutic targets to combat anthrax.
Lihong Wu, Yanping Chen, Yongyong Yan, Haiyan Wang, Cynthia D. Guy, John Carney, Carla L. Moreno, Anaisa Quintanilla-Arteaga, Fernando Monsivais, Zhichao Zheng, Mingtao Zeng   +10 more
doaj   +1 more source

Nationwide Characterization of MFN2‐Related CMT in 176 Japanese Patients: Clinical and Genetic Insights

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Mitofusin 2 (MFN2) is a major causative gene for axonal Charcot – Marie – Tooth disease type 2A (CMT2A), with a wide phenotypic spectrum. Comprehensive large ‐ scale genotype – phenotype association studies are essential for understanding disease pathogenesis and improved clinical management.
Masahiro Ando, Yujiro Higuchi, Jun‐Hui Yuan, Akiko Yoshimura, Chikashi Yano, Takahiro Hobara, Fumikazu Kojima, Yu Hiramatsu, Satoshi Nozuma, Tomonori Nakamura, Yusuke Sakiyama, Jun Mitsui, Shoji Tsuji, Hiroshi Takashima   +13 more
wiley   +1 more source

A Meta‐Analysis of the Effects of Early Life Stress on the Prefrontal Cortex Transcriptome Reveals Long‐Term Downregulation of Myelin‐Related Gene Expression

Brain and Behavior
Background Early life stress (ELS) refers to exposure to negative childhood experiences, such as neglect, disaster, and physical, mental, or emotional abuse.
Toni Q. Duan, Megan H. Hagenauer, Elizabeth I. Flandreau, Anne Bader, Duy Manh Nguyen, Pamela M. Maras, Randriely Merscher S. De Lima, Trevonn Gyles, Christabel Mclain, Michael J. Meaney, Eric J. Nestler, Stanley J. Watson Jr., Huda Akil   +12 more
doaj   +1 more source

Multiplexed heat shock protein microarray as a screening platform for the selection of novel drug compounds [PDF]

, 1914
Emilia Schax, Janek Neunaber, Frank Stahl, Johanna‐Gabriela Walter, Thomas Scheper, Simone Eichner, Andreas Kirschning, Carsten Zeilinger   +7 more
openalex   +1 more source

Mfuzz: A software package for soft clustering of microarray data

Bioinformation, 2007
For the analysis of microarray data, clustering techniques are frequently used. Most of such methods are based on hard clustering of data wherein one gene (or sample) is assigned to exactly one cluster.
Lokesh Kumar, Matthias E. Futschik
semanticscholar   +1 more source

Copy Number Variants and Their Association With Intracerebral Hemorrhage Risk: A Case–Control Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Intracerebral Hemorrhage (ICH) is a leading cause of morbidity and mortality worldwide and lacks effective therapeutic interventions. Despite previous studies, the genetic underpinnings of ICH remain poorly understood. We sought to investigate the role of copy number variants (CNVs) in ICH pathophysiology to identify novel ...
Savvina Prapiadou, Carl D. Langefeld, Padmini Sekar, Mary Comeau, Timothy Howard, Tamara N. Kimball, Chen Bowang, Hyacinth I. Hyacinth, Jonathan Rosand, Christopher D. Anderson, Caspar Grond‐Ginsbach, Daniel Woo, Stacie L. Demel   +12 more
wiley   +1 more source

Transcriptome and Metabolome Analyses Reveal That Nitrate Strongly Promotes Nitrogen and Carbon Metabolism in Soybean Roots, but Tends to Repress It in Nodules

Plants, 2018
Leguminous plants form root nodules with rhizobia that fix atmospheric dinitrogen (N2) for the nitrogen (N) nutrient. Combined nitrogen sources, particular nitrate, severely repress nodule growth and nitrogen fixation activity in soybeans (Glycine max [L.
Shinji Ishikawa, Yuki Ono, Norikuni Ohtake, Kuni Sueyoshi, Sayuri Tanabata, Takuji Ohyama   +5 more
doaj   +1 more source

LOXHD1 and RHOB Expression by Monocytes Predicts Progressive Systemic Sclerosis associated Interstitial Lung Disease

Arthritis Care &Research, Accepted Article.
Objective A leading cause of death among scleroderma (SSc) patients, interstitial lung disease (ILD) remains challenging to prognosticate. The discovery of biomarkers that accurately determine which patients would benefit from close monitoring and aggressive therapy would be an essential clinical tool.
Cristina M Padilla, Robert Lafyatis, Kevin F Gibson, Christina Morse, Eleanor Valenzi, Xiaoping Chen, Xiaoyun Li, Yanwu Zhao, Yongseok Park, Dana Ascherman, Jonathan Minden, Robyn Domsic, Yingze Zhang, Daniel J Kass   +13 more
wiley   +1 more source