Results 121 to 130 of about 27,010,024 (292)

Comparison and Analysis of Microarray Databases

, 2014
Microarray technology has become widely utilized by biologists as an important functional genomics approach. Combined with the Internet and web technologies, a load of microarray databases have been developed.
許輝煌, Hsu, Hui-Huang; Yang, Andy C.; Lu, Ming-Da   +1 more
core  

Clinical profile and cytogenetics of siblings with Jacobsen syndrome

Journal of Current Research in Scientific Medicine
The clinical care of patients has greatly benefited from the advancement of genetic testing. Over time, a gradual move toward a “genotype-first” strategy and growing use of genome-wide testing techniques such as chromosomal microarray analysis and next ...
Abinaya Gunalan, Priya Jose, Allen David, Peter Prasanth Kumar Kommu   +3 more
doaj   +1 more source

Thioredoxin‐2 Alleviates Osteoporosis by Restraining FOXO3a Nuclear Translocation

Advanced Science, EarlyView.
Endothelial TRX2 preserves bone homeostasis by retaining FOXO3a at mitochondria and limiting TRAIL production. Loss of TRX2 or oxidative stress releases FOXO3a for nuclear translocation, increasing endothelial TRAIL secretion and driving osteoclast formation and bone loss.
Chi Zhan, Zhaocai Zhou, Yue Ding, Rong Lian, Xinyu Li, Xintong Zhang, Jie Cao, Zhonghui Tang, Zhengmei Lin, Zhi Song, Feng He   +10 more
wiley   +1 more source

In Vivo CRISPR Screen Identifies RPS19 as an Immunotherapy Target in Hepatocellular Carcinoma

Advanced Science, EarlyView.
By employing in vivo CRISPR functional screening, we identify ribosomal protein RPS19 as a pivotal mediator driving immune evasion in hepatocellular carcinoma, wherein tumor‑released RPS19 binds C5aR1 on tumor‑associated macrophages to initiate downstream immunosuppressive signaling; SP94‑peptide‑modified SNPSS nanoparticles deliver Cas9/sgRPS19 ...
Lei He, Duo Yu, Fei Xie, Kaisheng Hou, Zhaozhao Li, Meifang Dai, Jingyi Yun, Haiyan Cao, Yang Xiao, Yueyuan Qiu, Gege Shi, Wangqian Zhang, Shuning Wang, Qiang Hao, Jieyu Zhang, Zhaowei Wang, Yingqi Zhang, Kuo Zhang, Jintao Gu, Haichen Du, Meng Li   +20 more
wiley   +1 more source

Bioinformatics protocols for analysis of functional genomics data applied to neuropathy microarray datasets [PDF]

, 2010
Microarray technology allows the simultaneous measurement of the abundance of thousands of transcripts in living cells. The high-throughput nature of microarray technology means that automatic analytical procedures are required to handle the sheer ...
Diboun, I.
core  

Assessment of data processing to improve reliability of microarray experiments using genomic DNA reference

BMC Genomics, 2008
Background Using genomic DNA as common reference in microarray experiments has recently been tested by different laboratories. Conflicting results have been reported with regard to the reliability of microarray results using this method.
Wu Liyou, Zhu Mengxia, Yang Yunfeng, Zhou Jizhong   +3 more
doaj   +1 more source

Using an attribute estimation technique for the analysis of microarray data

, 2003
We present an original method for the analysis of microarray data based on an attribute estimation technique. We show, in the context of radioactive environmental stress, that this method can be used to detect a small number of genes that, highly probably, are involved in the response to this stress in yeast.
Mary, Jérémie, Mercier, Guillaume, Comet, Jean-Paul, Cornuéjols, Antoine, Froidevaux, Christine, Dutreix, Marie   +5 more
openaire   +1 more source

CircFAM65A/CANX Condensates Sequester FAM134B to Inhibit ER‐phagy and Suppress Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
The novel circRNA circFAM65A suppresses HCC progression. Mechanistically, circFAM65A drives CANX phase separation, which recruits FAM134B into condensates and blocks its interaction with LC3, thereby inhibiting ER‐phagy and HCC progression. Importantly, targeted circFAM65A delivery represents a potential therapeutic strategy for HCC.
Wenxiu Ru, Lunbiao Gan, Yu Lu, Yujing Guo, Qian Huang, Sha Yin, Fengze Nie, Sijia Di, Jiaqi Ning, Siyu Yao, Huanhuan Wan, Le Liu, Zehua Liu, Fa Yang, Weijun Qin, Weihong Wen   +15 more
wiley   +1 more source

Microarray Data Analysis

, 2005
In this chapter, we discuss several analytical techniques and tools used in image analysis of microarray for data extraction and data analysis for pattern discovery such as cluster analysis, temporal expression profile analysis, and gene regulation ...
Liew, AWC, Yan, H, Yang, M, Chen, YPP, Alan W. -C. Liew, Y. -P. Phoebe Chen, Mengsu Yang, Hong Yan   +7 more
core   +1 more source

Chemoenzymatic Synthesis of 6‐Sulfo Sialyl Lewisx Containing Glycans to Probe the Receptor Specificity of MERS Coronavirus

Angewandte Chemie, EarlyView.
A chemoenzymatic methodology is described that provided a panel of 6‐sulfo sialyl Lewisx‐containing glycans that were probed for receptor specificity of MERS‐CoV. Although the fucoside of 6‐sulfo‐SLex does not directly interact with the spike, it pre‐organizes the molecule into a conformation to allow a salt bridge between the sulfate and the ...
Yunfei Wu, Anne L.M. Kimpel, Jacobus P. van Trijp, Elif Uslu, Gaёl M. Vos, Luca Unione, Robert P. de Vries, Geert‐Jan Boons   +7 more
wiley   +2 more sources