Results 171 to 180 of about 180,353 (259)
Standardization of Suspension and Imaging Mass Cytometry Single‐Cell Readouts for Clinical Decision Making
Cytometry Part A, EarlyView.ABSTRACT
Suspension and imaging mass cytometry are single‐cell, proteomic‐based methods used to characterize tissue composition and structure. Data assessing the consistency of these methods over an extended period of time are still sparse and are needed if mass cytometry‐based methods are to be used clinically.Ruben Casanova, Shuhan Xu, Pierre Bost, Sujana Sivapatham, Andrea Jacobs, Stefanie Engler, Tumor Profiler Consortium, Rudolf Aebersold, Melike Ak, Faisal S Al‐Quaddoomi, I Albert Silvana, Jonas Albinus, Ilaria Alborelli, Sonali Andani, Per‐Olof Attinger, Marina Bacac, Daniel Baumhoer, Beatrice Beck‐Schimmer, Niko Beerenwinkel, Christian Beisel, Lara Bernasconi, Anne Bertolini, Bernd Bodenmiller, Ximena Bonilla, Lars Bosshard, Byron Calgua, Ruben Casanova, Stéphane Chevrier, Natalia Chicherova, Ricardo Coelho, Maya D’Costa, Esther Danenberg, Natalie R Davidson, Monica‐Andreea Drăgan, Reinhard Dummer, Stefanie Engler, Martin Erkens, Katja Eschbach, Cinzia Esposito, André Fedier, Pedro F Ferreira, Joanna Ficek‐Pascual, Anja L Frei, Bruno Frey, Sandra Goetze, Linda Grob, Gabriele Gut, Detlef Günther, Pirmin Haeuptle, Viola Heinzelmann‐Schwarz, Sylvia Herter, Rene Holtackers, Tamara Huesser, Alexander Immer, Anja Irmisch, Francis Jacob, Andrea Jacobs, Tim M Jaeger, Katharina Jahn, Alva R James, Philip M Jermann, André Kahles, Abdullah Kahraman, Viktor H Koelzer, Werner Kuebler, Jack Kuipers, Christian P Kunze, Christian Kurzeder, Kjong‐Van Lehmann, Mitchell Levesque, Ulrike Lischetti, Flavio C Lombardo, Sebastian Lugert, Gerd Maass, Markus G Manz, Philipp Markolin, Martin Mehnert, Julien Mena, Julian M Metzler, Nicola Miglino, Emanuela S Milani, Holger Moch, Simone Muenst, Riccardo Murri, Charlotte KY Ng, Stefan Nicolet, Marta Nowak, Monica Nunez Lopez, Patrick GA Pedrioli, Lucas Pelkmans, Salvatore Piscuoglio, Michael Prummer, Laurie Prélot, Natalie Rimmer, Mathilde Ritter, Christian Rommel, María L Rosano‐González, Gunnar Rätsch, Natascha Santacroce, Jacobo Sarabia del Castillo, Ramona Schlenker, Petra C Schwalie, Severin Schwan, Tobias Schär, Gabriela Senti, Wenguang Shao, Franziska Singer, Sujana Sivapatham, Berend Snijder, Bettina Sobottka, Vipin T Sreedharan, Stefan Stark, Daniel J Stekhoven, Tanmay Tanna, Alexandre PA Theocharides, Tinu M Thomas, Markus Tolnay, Vinko Tosevski, Nora C Toussaint, Mustafa A Tuncel, Marina Tusup, Audrey Van Drogen, Marcus Vetter, Tatjana Vlajnic, Sandra Weber, Walter P Weber, Rebekka Wegmann, Michael Weller, Fabian Wendt, Norbert Wey, Andreas Wicki, Mattheus HE Wildschut, Bernd Wollscheid, Shuqing Yu, Johanna Ziegler, Marc Zimmermann, Martin Zoche, Gregor Zuend, Mitchell P. Levesque, Reinhard Dummer, Bernd Bodenmiller, Stéphane Chevrier +141 morewiley +1 more sourceProstate cancer and metabolic syndrome: exploring shared signature genes through integrative analysis of bioinformatics and clinical data. [PDF]
Discov OncolGuo M, Liang S, Guan Z, Mao J, Xu Z, Zhao W, Bian H, Zhu J, Wang J, Jin X, Xia Y. +10 moreeuropepmc +1 more sourceRodent monocyte‐derived macrophages do not express CD163: Comparative analysis using macrophages from living boreoeutherians
Developmental Dynamics, EarlyView.Abstract Background
CD163 is a scavenger receptor predominantly expressed on the surfaces of macrophages in various mammalian species and is a marker of anti‐inflammatory (M2‐like) macrophages. High density of CD163‐positive tumor‐associated macrophages (TAMs) is associated with worse prognosis in various patient tumors.Yoichi Saito, Yukio Fujiwara, Yasuka L. Yamaguchi, Satomi S. Tanaka, Kyoko Miura, Yoshiyuki Hizukuri, Kyoko Yamashiro, Yasuhiro Hayashi, Yuta Nakashima, Yoshihiro Komohara +9 morewiley +1 more sourceMulti‐microRNA diagnostic panel for heart failure with preserved ejection fraction in preclinical and clinical settings
ESC Heart Failure, EarlyView.Abstract Aims
Heart failure with preserved ejection fraction (HFpEF) is a complex syndrome accounting for half of heart failure cases. Although natriuretic peptides are the most accepted and extensively used biomarkers for heart failure, their diagnostic accuracy for HFpEF remains debatable.Reza Parvan, Natale Rolim, Andreas B. Gevaert, Alessandro Cataliotti, Emeline M. van Craenenbroeck, Volker Adams, Ulrik Wisløff, Gustavo Jose Justo Silva, on behalf of
the OptimEx Study Group +8 morewiley +1 more sourceThe transcriptional profile of iron deficiency in patients with heart failure: Heme‐sparing and reduced immune processes
European Journal of Heart Failure, EarlyView.The analysis workflow, findings and potential clinical consequences of iron deficiency in heart failure (HF). From 881 patients with worsening HF, whole blood transcriptome was analysed using the Affymetrix Human Transcriptome Array (HTA) 2.0. Subjects were stratified according to their transferrin saturation (TSAT) levels as iron‐deficient (TSAT <20%) Niels Grote Beverborg, Ridha I.S. Alnuwaysir, George Markousis‐Mavrogenis, Martijn F. Hoes, Haye H. van der Wal, Simon P.R. Romaine, Mintu Nath, Andrea Koekoemoer, John G.F. Cleland, Chim C. Lang, Stefan D. Anker, Kenneth Dickstein, Marco Metra, Leong L. Ng, Dirk J. van Veldhuisen, Adriaan A. Voors, Nilesh J. Samani, Peter van der Meer +17 morewiley +1 more sourceIdentifying a unique chromosomal pattern to predict the gemcitabine response in patients with cholangiocarcinoma. [PDF]
Sci RepTecha-Ay S, Watcharadetwittaya S, Deenonpoe R, Sa-Ngiamwibool P, Panwoon C, Loilome W, Klanrit P, Techasen A, Chamgramol Y, Suksawat M, Armartmuntree N, O'Connor T, Saya H, Thanee M. +13 moreeuropepmc +1 more sourceInterpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting
Environmental and Molecular Mutagenesis, EarlyView.Abstract
Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...Marc A. Beal, Guangchao Chen, Kerry L. Dearfield, Min Gi, Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Alexandra S. Long, David P. Lovell, Barbara L. Parsons, Stefan Pfuhler, John Wills, Andreas Zeller, George Johnson, Paul A. White +14 morewiley +1 more sourceRefined culture conditions with increased physiological relevance uncover oncogene-dependent metabolic signatures in Ewing sarcoma spheroids. [PDF]
Cell Rep MethodsCeranski AK, Carreño-Gonzalez MJ, Ehlers AC, Hanssen KM, Gmelin N, Geyer FH, Kolodynska Z, Vinca E, Faehling T, Poeller P, Ohmura S, Cidre-Aranaz F, Schulze A, Grünewald TGP. +13 moreeuropepmc +1 more source
