Results 111 to 120 of about 303,799 (288)

Microenvironment Self‐Adaptive Nanoarmor to Address Adhesion‐ and Colonization‐Related Obstacles in Impaired Intestine Promote Bacteriotherapy Against Parkinson's Disease

Advanced Science, EarlyView.
A microenvironment self‐adaptive nanoarmor is developed to effectively address the adhesion‐ and colonization‐related challenges posed by multiple physiological and pathological characteristics in the intestine. L. plantarum@MPN@CS showed significant therapeutic potential in treating Parkinson's disease (PD), a model for extraintestinal disorders, as ...
Limeng Zhu, Yuyu Wu, Yingjie Chen, Xiyi Chen, Xingjie Zan, Yanlong Liu, Wujun Geng   +6 more
wiley   +1 more source

Conformable Device for Independent Measurements of Mucosal and Vascular Barriers in a Complex In Vitro Intestinal Model

Advanced Science, EarlyView.
Development of more complex in vitro models necessitates the development of improved monitoring approaches. This work demonstrates a novel conformable device capable of measuring the resistance of two cell barriers within a single model independently, a significant advantage over conventional trans‐epithelial/endothelial electrical resistance (TEER ...
Alexandra Elisabeth Wheeler, Sonja Blasche, Rob Bradley, Rachana Acharya, Sophie Oldroyd, David Bulmer, Kiran R. Patil, Róisín Meabh Owens   +7 more
wiley   +1 more source

Characterization of Microbial Communities on the Surfaces of Building Entrance and Restroom Door Handles [PDF]

Min Seok Ki, Sung Yong Park, Hyuk Sang Kwon, Soo Min Kim, Dong Hwon Son, Han Ul Jung, Jae Hun Kim, Ye Jin Kim, Kwang J. Kim, Hyeong-Seok Lee, Young Whan Sung, Jeong Wook Jo, Hyung Joo Kim   +12 more
openalex   +1 more source

Extracellular Vesicles of Streptococcus anginosus Mediate Gastritis via Epithelial Barrier Disruption and Macrophage‐driven Inflammation

Advanced Science, EarlyView.
Streptococcus anginosus extracellular vesicles (SA‐EVs) accumulate in gastric tissue, disrupt epithelial tight junctions, and induce gastritis characterized by neutrophil infiltration and elevated cytokines (TNF‐α, IL‐6, IL‐17A). Proteomics identifies TMPC and FBP62 as key SA‐EVs virulence factors; their genetic deletion attenuates inflammation ...
Ying Gong, Lina Duan, Jie Xiao, Yulu Deng, Hongxia Wang, Yajie Zhang, Xiumei Hu, Haifang Wang, Taixue An, Xin Li, Yurong Qiu, Lei Zheng, Haixia Li   +12 more
wiley   +1 more source

Startup performance and microbial communities of a decentralized anaerobic digestion of food waste

, 2023
Yong Wei Tiong, Pooja Sharma, Hailin Tian, To‐Hung Tsui, Heng Thong Lam, Yen Wah Tong   +5 more
openalex   +1 more source

Dipiperazine‐Phenyl Derivatives Based on Convergent Molecular Platforms Can Reverse Multidrug Resistance in Gram‐Negative Bacteria by Inhibiting Efflux and Permeabilizing Cell Membranes

Advanced Science, EarlyView.
By integrating a convergent molecular platform strategy, this study designed a novel dual‐target C5 to combat multidrug‐resistant Gram‐negative bacteria. C5 synergistically enhances antibiotic efficacy by inhibiting efflux pumps and increasing bacterial membrane permeability.
Jiale Dong, Ting Guo, Yi Huang, Yangchun Ma, Weijin Chen, Jie Xue, Jun Jiang, Enhui Dong, Yue Kong, Hang Ding, Wenlong Zhang, Shutao Ma   +11 more
wiley   +1 more source

The Gut Microbiota Regulates Motor Deficits via Butyrate in a Gnal+/− Mouse Model of DYT25 Dystonia

Advanced Science, EarlyView.
The present study provides compelling evidence for a modulatory role of the gut microbiota in the pathology of DYT25 dystonia, and butyrate supplementation alleviates the motor deficits of dystonia in Gnal+/− mice. Abstract Dystonia is the third most common movement disorder, following essential tremor and Parkinson's disease. The underlying mechanisms
Jingya Guo, Seong‐Gook Kang, Kunlun Huang, Tao Tong   +3 more
wiley   +1 more source

MGM as a Large‐Scale Pretrained Foundation Model for Microbiome Analyses in Diverse Contexts

Advanced Science, EarlyView.
We present the Microbial General Model (MGM), a transformer‐based foundation model pretrained on over 260,000 microbiome samples. MGM learns contextualized microbial representations via self‐supervised language modeling, enabling robust transfer learning, cross‐regional generalization, keystone taxa discovery, and prompt‐guided generation of realistic,
Haohong Zhang, Yuli Zhang, Zixin Kang, Jiayun Xiong, Ronghua Yang, Kang Ning   +5 more
wiley   +1 more source

Comparison of the gut microbial community between obese and lean peoples using 16S gene sequencing in a Japanese population

, 2016
Akira Andoh, Atsushi Nishida, Kenichiro Takahashi, Osamu Inatomi, Hirotsugu Imaeda, Shigeki Bamba, Katsuyuki Kito, Mitsushige Sugimoto, Toshio Kobayashi   +8 more
openalex   +2 more sources

Hump‐Shaped Relationship Between Microbial Carbon Use‐Efficiency and Soil Organic Carbon in Alpine Grasslands

Advanced Science, EarlyView.
On the Qinghai–Tibetan Plateau, microbial carbon use efficiency (CUE) peaks at intermediate soil organic carbon levels and declines thereafter. In carbon‐rich soils, the formation of stable mineral‐associated organic carbon is decoupled from microbial CUE.
Yuting Wang, Yongneng Wei, Gangsheng Wang, Yang Ruan, Ling Li, Xiang Liu, Yunfeng Yang, Qirong Shen, Ning Ling   +8 more
wiley   +1 more source