Results 1 to 10 of about 2,531,012 (309)

Programmable Klebsiella pneumoniae Phage Tropism Enabled by Scalable Receptor‐Binding Protein Mining and Modular Assembly

Advanced Science
Phage therapy is an attractive countermeasure to multidrug‐resistant pathogens, but clinical deployment is limited by the narrow and poorly predictable host range of most phages. Public repositories now house tens of thousands of phage genomes, yet there
Shisong Jing, Yiyao Song, Xianbiao Bi, Yuqin Song, Dawei Wei, Jiangqing Huang, Yuan Zeng, Gang Zhang, Rong Zhang, Chao Wang, Jie Feng   +10 more
doaj   +1 more source

Paraboremia selaginellae enhances Salvia miltiorrhiza growth and cadmium tolerance via modulating root architecture and cadmium speciation in contaminated environments

Frontiers in Plant Science
IntroductionDark septate endophytes (DSEs) commonly colonize plant roots in heavy metal-polluted habitats, but little is known about the potential mechanisms driving medicinal plants to adapt to heavy metal-polluted environments.
Yuli Lin, Yuli Lin, Zhenzhou Wang, Zhenzhou Wang, Wenjing Chen, Wenjing Chen, Yunfeng Liu, Yunfeng Liu, Xia Li, Xia Li, Hongliang Tang, Hongliang Tang, Xueli He, Xueli He   +13 more
doaj   +1 more source

Temperature-driven metabolic adaptation in thermophilic microbial communities of Western Sichuan hot springs

BMC Microbiology
Background Understanding microbial adaptation to extreme environments remains a key challenge in microbial ecology. Geothermal hot springs, characterized by temperature gradients and varying geochemical conditions, represent valuable natural laboratories
Sainan Luo, Xiuzhen Chen, Shunchao Guo, Songnian Hu, Zhiyang Dong, Jianing Geng   +5 more
doaj   +1 more source

New bioactive secondary metabolites from fungi: 2025

Mycology
Fungi continue to be a rich source of structurally unique and biologically active secondary metabolites. In 2025, a total of 992 novel fungal secondary metabolites (including 26 pairs of optical isomers and a pair of rotamers) were reported, comprising ...
Xiaoyi Gong, Luojing Wang, Meiyan Bao, Ling Liu   +3 more
doaj   +1 more source

Integrative analysis of fungal communities in three types of Baijiu Daqu using third-generation sequencing and culturomics

Frontiers in Microbiology
Daqu, the core fermentation starter for Chinese Baijiu, harbors intricate and functionally important fungal communities. To comprehensively characterize its biodiversity, we employed an integrated approach combining third-generation amplicon sequencing ...
Yu-Hua Wei, Yu-Hua Wei, Da-Yong Han, Liang Song, Liang-Chen Guo, Liang-Chen Guo, Mei Bai, Mei Bai, Pei-Jie Han, Hai-Yan Zhu, Zhang Wen, Zhang Wen   +11 more
doaj   +1 more source

Prokaryotic defense systems: Diversity and evolutionary adaptation

mLife
Bacteriophages and archaeal viruses are the most abundant biological entities on Earth. Through a long‐standing co‐evolutionary arms race, they have driven the emergence of a diverse repertoire of prokaryotic defense systems. This review summarizes these
Changjialian Yang, Luyao Gong, Jing Guo, Hua Xiang   +3 more
doaj   +1 more source

Genome-Wide Landscape of Position Effect Variegation in Pichia pastoris

Journal of Fungi
Exogenous genes are generally expressed by integration into the chromosomes of Pichia pastoris. However, systematic studies on the chromosomal position effect are lacking, and locations that are conducive to the high expression of foreign genes are ...
Xueyan Yao, Baosong Chen, Zhihui Zhang, Wenyan Gao, Qian Zhang, Yongpeng Yao, Yuanyuan Pan, Gang Liu   +7 more
doaj   +1 more source

Editorial for the Special Issue “Microbial Diversity and Microbial Resistance”

Biology
In the beginning, it was diversity—or so evolutionary biology suggest when interpreting how and why antibiotic production began on Earth [...]
Chrysoula (Chrysa) Voidarou, Athina Tzora   +1 more
openaire   +3 more sources

Deletion of bZIP Transcription Factor PratfA Reveals Specialized Metabolites Potentially Regulating Stress Response in Penicillium raistrickii

Journal of Fungi
Fungal secondary metabolism (SM) is highly correlated with physiological processes that are typically regulated by pleiotropic regulators. In this study, we purposefully altered PratfA, a crucial regulator associated with oxidative stress in Penicillium ...
Anxin Zhang, Shu Zhang, Xinran Xu, Wen-Bing Yin   +3 more
doaj   +1 more source

Identification of targets for high penicillin G production in an industrial strain of Penicillium rubens

Applied Microbiology and Biotechnology
To elucidate the mechanisms underlying high penicillin G (PenG) production, transcriptomic analysis was conducted on 36 samples from the reference Penicillium rubens Wisconsin 54-1255 and its industrial descendant strain IMP002. The resulting dataset was
Kaiqi Dou, Yuanyuan Pan, Yongpeng Yao, Xiuyun Tian, Ning Guo, Gang Liu   +5 more
doaj   +1 more source