Results 41 to 50 of about 316,818 (267)
Antisense Transcription Is Pervasive but Rarely Conserved in Enteric Bacteria
mBio, 2012 Noncoding RNAs, including antisense RNAs (asRNAs) that originate from the complementary strand of protein-coding genes, are involved in the regulation of gene expression in all domains of life.
Rahul Raghavan +2 more
doaj +1 more source
Diversity of Microbial Metal Sulfide Biomineralization
ChemPlusChem, 2021 AbstractSince the emergence of life on Earth, microorganisms have contributed to biogeochemical cycles. Sulfate‐reducing bacteria are an example of widespread microorganisms that participate in the metal and sulfur cycles by biomineralization of biogenic metal sulfides.
Park, Yeseul, Faivre, Damien
openaire +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Nature CommunicationsSorangium cellulosum is a cellulolytic myxobacterium that produces a vast array of complex natural products with diverse chemical scaffolds and biological activities.
Xiaotong Zhong +11 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Development of a lysine biosensor for the dynamic regulation of cadaverine biosynthesis in E. coli
Microbial Cell FactoriesBackground As one of the most promising monomers of biobased polyamides, cadaverine has wide industrial application prospects. However, in microbial cadaverine fermentation with glucose as the sole carbon source, the impaired coordination between ...
Mingjie Li +6 more
doaj +1 more source
CRISPR/Cas9 nickase-mediated cytosine base editing in Trichoderma koningiopsis
MycologyBase editors are regarded as reliable and precise editing tools due to their ability to efficiently and accurately modify the target genes without inducing double-strand breaks (DSBs).
Yushi Fu +6 more
doaj +1 more source
Reply to “The Underestimation of Global Microbial Diversity” [PDF]
mBio, 2016 This work, including the efforts of Rudolf Amann, was funded by Max Planck Society. This work, including the efforts of Ramon Rossello-Mora, was funded by CSIC.
Amann, R., Rossello-Mora, R.
openaire +5 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
New bioactive secondary metabolites from fungi: 2024
MycologyFungi have been recognised as a prolific source of structurally unique secondary metabolites with promising pharmacological properties. This review comprehensively summarises the chemical architectures, bioactivities, and research strategies for new ...
Meiyan Bao +6 more
doaj +1 more source