Results 41 to 50 of about 361,751 (317)

CRISPR/Cas9 nickase-mediated cytosine base editing in Trichoderma koningiopsis

Mycology
Base editors are regarded as reliable and precise editing tools due to their ability to efficiently and accurately modify the target genes without inducing double-strand breaks (DSBs).
Yushi Fu, Yuxia Duan, Yongpeng Yao, Yuanyuan Pan, Zhaoqing Zeng, Wenying Zhuang, Gang Liu   +6 more
doaj   +1 more source

Diversity of Microbial Metal Sulfide Biomineralization

ChemPlusChem, 2021
AbstractSince the emergence of life on Earth, microorganisms have contributed to biogeochemical cycles. Sulfate‐reducing bacteria are an example of widespread microorganisms that participate in the metal and sulfur cycles by biomineralization of biogenic metal sulfides.
Park, Yeseul, Faivre, Damien
openaire   +2 more sources

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Comparative analysis of pyrosequencing and a phylogenetic microarray for exploring microbial community structures in the human distal intestine [PDF]

, 2009
BACKGROUND: Variations in the composition of the human intestinal microbiota are linked to diverse health conditions. High-throughput molecular technologies have recently elucidated microbial community structure at much higher resolution than was ...
Vos, W.M., de, Willem M de Vos, O\u27Toole, Paul W., Smidt, H., O'Sullivan, O., Janne Nikkilä, Claesson Marcus J., de Vos Willem M., Hauke Smidt, O'Sullivan, Orla, Marchesi, Julian Roberto, O\u27Sullivan, Orla, Ross R. Paul, Smidt, Hauka, Ross, R. Paul, Ross, R. P., Paul W O'Toole, Wang, Qiong, Orla O'Sullivan, O'Sullivan Orla, de Vos, W.M., Qiong Wang, Nikkilä Janne, O'Toole, Paul W., Claesson, M.J., Marchesi, J.R., O'Toole, P.W., Claesson, Marcus J., O'Toole, P. W., Wang, Q., de Vos, Willem M., Claesson, M. J., Julian R Marchesi, O'Toole Paul W., Marchesi, Julian R., Smidt, Hauke, Ross, R.P., Smidt Hauke, Nikkila, Janne, R Paul Ross, Marchesi Julian R., Ross, R Paul, Wang Qiong, De Vos, W. M., Nikkilä, J., Marcus J Claesson   +45 more
core   +1 more source

Diversity of oligosaccharides in lipooligosaccharides of Akkermansia muciniphila and its anti-atherosclerotic activity

Natural Products and Bioprospecting
As an important and beneficial gut commensal, Akkermansia muciniphila plays a crucial role in regulating host metabolism and immunity. Lipooligosaccharides from A. muciniphila (ALOS) show anti-obesity effects in high-fat diet-fed mice.
Yuting Zhang, Wang Dong, Jinghan Lin, Jingzu Sun, Ruopeng Yin, Xun Lv, Wenzhao Wang, Tao Wang, Hongwei Liu   +8 more
doaj   +1 more source

Touching the (almost) untouchable: a minimally invasive workflow for microbiological and biomolecular analyses of cultural heritage objects

Frontiers in Microbiology, 2023
Microbiological and biomolecular approaches to cultural heritage research have expanded the established research horizon from the prevalent focus on the cultural objects' conservation and human health protection to the relatively recent applications to ...
Cecilia G. Flocco, Anika Methner, Franziska Burkart, Alicia Geppert, Jörg Overmann, Jörg Overmann   +5 more
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Microbial diversity in contaminated soil [PDF]

, 2002
Little is known about soil population dynamics: how microbial communities are affected by environmental stress; whether they respond adversely, or adjust to it; what the extent and duration of these adjustments might be; which genera of bacteria are ...
O'flaherty, S. M.
core  

Genetic engineering of Sorangium cellulosum reveals hidden enzymology in myxobacterial natural product biosynthesis

Nature Communications
Sorangium cellulosum is a cellulolytic myxobacterium that produces a vast array of complex natural products with diverse chemical scaffolds and biological activities.
Xiaotong Zhong, Shan Liu, Bingda Ma, Kaining Gao, Dayong Jiang, Yingshuo Hou, Huliang Chen, Jiaqi Lv, James I. Bowen, Matthew P. Crump, Christine L. Willis, Luoyi Wang   +11 more
doaj   +1 more source

Three New Fungi from China: A Potentially Psychoactive Psilocybe and Two Deconica Species

Journal of Fungi
The saprotrophic genera Deconica and Psilocybe exhibit broad geographic distributions across temperate and subtropical biomes globally. Despite China’s rich fungal diversity, taxonomic studies of these genera remain limited, with few species previously ...
Hai-Ying Feng, Jia-Xin Li, Wen-Qiang Yang, Bin Cao, Rui-Lin Zhao   +4 more
doaj   +1 more source