Results 51 to 60 of about 2,531,012 (309)
Trifunctional flavoenzyme-catalyzed asymmetric 4-alkyl-butenolide assembly in avenolide biosynthesis
Nature CommunicationsButenolides are important features of many bioactive compounds. Current petrochemical-based methods for asymmetric butenolide synthesis are unsustainable. Biocatalysis could enable cheaper, greener, and more sustainable alternatives.
Wenrui Li +9 more
doaj +1 more source
Antisense Transcription Is Pervasive but Rarely Conserved in Enteric Bacteria
mBio, 2012 Noncoding RNAs, including antisense RNAs (asRNAs) that originate from the complementary strand of protein-coding genes, are involved in the regulation of gene expression in all domains of life.
Rahul Raghavan +2 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Natural Products and BioprospectingAs an important and beneficial gut commensal, Akkermansia muciniphila plays a crucial role in regulating host metabolism and immunity. Lipooligosaccharides from A. muciniphila (ALOS) show anti-obesity effects in high-fat diet-fed mice.
Yuting Zhang +8 more
doaj +1 more source
CRISPR/Cas9 nickase-mediated cytosine base editing in Trichoderma koningiopsis
MycologyBase editors are regarded as reliable and precise editing tools due to their ability to efficiently and accurately modify the target genes without inducing double-strand breaks (DSBs).
Yushi Fu +6 more
doaj +1 more source
Diversity of Microbial Metal Sulfide Biomineralization
ChemPlusChem, 2021 AbstractSince the emergence of life on Earth, microorganisms have contributed to biogeochemical cycles. Sulfate‐reducing bacteria are an example of widespread microorganisms that participate in the metal and sulfur cycles by biomineralization of biogenic metal sulfides.
Park, Yeseul, Faivre, Damien
openaire +2 more sources
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Nature CommunicationsSorangium cellulosum is a cellulolytic myxobacterium that produces a vast array of complex natural products with diverse chemical scaffolds and biological activities.
Xiaotong Zhong +11 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Development of a lysine biosensor for the dynamic regulation of cadaverine biosynthesis in E. coli
Microbial Cell FactoriesBackground As one of the most promising monomers of biobased polyamides, cadaverine has wide industrial application prospects. However, in microbial cadaverine fermentation with glucose as the sole carbon source, the impaired coordination between ...
Mingjie Li +6 more
doaj +1 more source