Results 71 to 80 of about 669,933 (281)

Noncanonical Peloruside A Biosynthesis by an Uncultivated Verrucomicrobiota Symbiont

Angewandte Chemie, EarlyView.
Noncanonical biochemistry of the peloruside PKS characterized in this work, comprising double bond generation by a noncanonical tridomain (blue), acetyl‐CoA recycling (orange), and proofreading systems (purple and yellow). The Z‐double bond is installed by TEB1 through O‐acetylation and acetate elimination. The acyl ligase PelB (AL, orange) selectively
Amy E. Fraley, Michael Rust, Moritz Wagner, Ida R. Hipfinger, Paul J. N. Böhm, Cora L. Dieterich, Christopher M. Field, Michael J. Page, Jeremy G. Owen, Robert A. Keyzers, Shinichi Sunagawa, Jörn Piel   +11 more
wiley   +2 more sources

Oligosaccharides With Defined Glycosidic Bonds Shape Gut Microbial Succession and Metabolism Via Bond‐Specific Microbial Responders

Advanced Science, EarlyView.
Oligosaccharides with defined glycosidic bonds drive divergent gut microbial succession and shape unique metabolic profiles. Absolute time‐series profiling with Bayesian generalized Lotka–Volterra modeling identifies bond‐specific microbial responders, while monoculture validation and metaproteomics reveal linkage‐matched transport and cleavage modules.
Xiaoxuan Lu, Jiaqi Zou, Geng Han, Mengyao Zhao, Ting Luo, Xiangru Feng, Liangliang Zhu, Yijia Chen, Xiaoguo Ji, Jiayang Jin, Liming Zhao   +10 more
wiley   +1 more source

Model Microbial Consortia as Tools for Understanding Complex Microbial Communities [PDF]

Current Genomics, 2018
A major biological challenge in the postgenomic era has been untangling the composition and functions of microbes that inhabit complex communities or microbiomes. Multi-omics and modern bioinformatics have provided the tools to assay molecules across different cellular and community scales; however, mechanistic knowledge over microbial interactions ...
Haruta, Shin, Yamamoto, Kyosuke
openaire   +2 more sources

Microbial consortia of biological products: Do they have a future?

Biological Control
Beneficial microbes play crucial role in modern agriculture, serving as biopesticides, biostimulants/biofertilizers, and alleviating abiotic stress in crops.
Peterson S.O. Nunes, Gileno V. Lacerda-Junior, Gabriel M. Mascarin, Rafaela A. Guimarães, Flavio H.V. Medeiros, Steven Arthurs, Wagner Bettiol   +6 more
doaj   +1 more source

Quorum Sensing Communication Modules for Microbial Consortia [PDF]

ACS Synthetic Biology, 2016
The power of a single engineered organism is limited by its capacity for genetic modification. To circumvent the constraints of any singular microbe, a new frontier in synthetic biology is emerging: synthetic ecology, or the engineering of microbial consortia.
Spencer R, Scott, Jeff, Hasty
openaire   +2 more sources

Enhanced Endophytic Colonization of Flavobacterium Promotes Plant Resistance to Fusarium Wilt

Advanced Science, EarlyView.
A natural microbial consortium employing a cross‐feeding strategy forms a stratified biofilm that promotes endophytic colonization of auxotrophic Flavobacterium. This enhanced colonization activates plant systemic resistance, effectively suppressing Fusarium wilt.
Xianfeng Ye, Changsheng Xu, Shuai Yao, Jiming Shen, Zeyuan Li, Yu Zhang, Fan Wu, Xinjie Li, Yanling Ji, Lei Zhang, Yan Huang, Zhoukun Li, Huayu Qin, Zhongli Cui   +13 more
wiley   +1 more source

Engineering microbial consortia to enhance biomining and bioremediation [PDF]

Frontiers in Microbiology, 2012
In natural environments microorganisms commonly exist as communities of multiple species that are capable of performing more varied and complicated tasks than clonal populations. Synthetic biologists have engineered clonal populations with characteristics such as differentiation, memory, and pattern formation, which are usually associated with more ...
Brune, Karl D., Bayer, Travis S.
openaire   +3 more sources

Metabolically cohesive microbial consortia and ecosystem functioning [PDF]

, 2020
Recent theory and experiments have reported a reproducible tendency for the coexistence of microbial species under controlled environmental conditions.
Bonhoeffer, Sebastian, Pascual Garcia, Alberto, Bell, Thomas, Bell T, Pascual-García A, Bonhoeffer S   +5 more
core   +1 more source

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

Advanced Science, EarlyView.
Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...
Lixiang Xie, Ziye Huang, Zhiyuan Zhang, Yiqiang Zhu, Xiaoqing Liu, Lei Wang, Tongyu Bi, Taizhen Liang, Jintao Lai, Meilin Hu, Guochang Qiu, Shiqi Xiao, Sen Liu, Yaoming Liu, Haiyue Rao, Tao Chen, Haojie Peng, Bin Zhang, Jia Tang, Qianying Li, Yaxin Li, Yuxin Hou, Weibo Yang, Hewei Jiang, Xiancai Ma   +24 more
wiley   +1 more source

Exploring the Relationship Between Clostridium thermocellum JN4 and Thermoanaerobacterium thermosaccharolyticum GD17

Frontiers in Microbiology, 2019
Characterizing and engineering microbial communities for lignocellulosic biofuel production has received widespread attention. Previous research has established that Clostridium thermocellum JN4 and Thermoanaerobacterium thermosaccharolyticum GD17 ...
Fangzhong Wang, Fangzhong Wang, Mingyu Wang, Qi Zhao, Kangle Niu, Shasha Liu, Didi He, Yan Liu, Shiping Xu, Xu Fang   +9 more
doaj   +1 more source