Results 161 to 170 of about 619,826 (239)

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva   +23 more
wiley   +1 more source

ISAba1‐mediated crp‐osmC amplification enhances host‐associated fitness in Acinetobacter baumannii

open access: yesmLife, EarlyView.
Abstract Acinetobacter baumannii is a pathogen, highly adaptable to both hospital‐ and host‐associated environments. Understanding the genetic mechanisms underlying its adaptability is critical for controlling its persistence. Our study identified the crp‐osmC gene cluster, flanked by ISAba1 elements, as a significant genetic structure undergoing ...
Da‐Wei Wei   +7 more
wiley   +1 more source

Incidence of unplanned gastrostomy tube replacements and associated complications in people with motor neurone disease and other conditions: A retrospective audit of an Australian dietitian‐led clinic

open access: yesNutrition in Clinical Practice, EarlyView.
Abstract Background Gastrostomy tube placement is a common intervention for long‐term nutrition in people with dysphagia. Minimising complications such as tube dislodgement is integral in gastrostomy management, as unplanned replacements may require urgent care to prevent stoma closure.
Emily Farrugia   +6 more
wiley   +1 more source

Deciphering the Inflammatory Network in Pediatric Recurrent Tonsillitis: The Role of TRAF6, IRAK1, and miR‐146a‐5p

open access: yesOtolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To investigate the role of TNF receptor‐associated factor 6 (TRAF6), interleukin 1 receptor‐associated kinase 1 (IRAK1), and miR‐146a‐5p expression levels in the pathogenesis of recurrent tonsillitis. Study Design Case‐control study. Setting The study was conducted at the Department of Otorhinolaryngology, Muğla Training and Research
Ömer Faruk Güzel   +3 more
wiley   +1 more source

Does acute inflammation triggered by infection promote cancer progression? [PDF]

open access: yesPLoS Biol
Valença-Pereira F   +3 more
europepmc   +1 more source

Interplanetary frontiers: terraforming from an invasion science perspective

open access: yesOikos, EarlyView.
The pursuit of a multi‐planetary existence represents one of humanity's greatest frontiers. If applied justly, it offers an opportunity to extend its civilization's lifespan amid escalating sustainability crises on Earth. One approach increasingly gaining traction is terraforming, a hitherto theoretical ecological and evolutionary experiment revolving ...
Teun Everts   +2 more
wiley   +1 more source

Integrating and assessing metacommunity drivers of ecosystem function and resilience in benthic algal systems

open access: yesOikos, EarlyView.
Understanding the scales and mechanisms by which species composition interacts with ecosystem functions is critical for forecasting the effects of environmental perturbations on ecosystem services. However, the linkages between what regulates the ecosystem functions of dispersal‐capable networks of communities (metacommunities) and what regulates a ...
Thomas P. Shannon, Evelyn E. Gaiser
wiley   +1 more source

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