Results 81 to 90 of about 619,826 (239)

Tumor Exposomics: A New Paradigm for Individualized Continuous Exposure Monitoring

Advanced Science, EarlyView.
Tumor exposomics integrates continuous monitoring of environmental exposures, endogenous biological responses, and behavioral factors within a unified temporal framework. By combining multimodal sensing technologies with AI‐enabled causal modeling, this emerging paradigm reconstructs exposure‐damage trajectories and supports individualized dynamic risk
Kaicheng Shen, Weiyi Wang, Yang Wang, Yiqiang Wu, Xiaohong Liu, Wei Zhang, Juanjuan Ou   +6 more
wiley   +1 more source

Sensitivity to hypoxia and microbial activity are instrumental in pericarp-imposed dormancy expression in sunflower (Helianthus annuus L.)

, 2019
We used two sunflower genotypes displaying pericarp-imposed dormancy at high incubation temperatures (i.e. 30°C) to investigate the role of the pericarp as a limitation to oxygen availability to the embryo (hypoxia), and its impact on embryo abscisic ...
Mantese, Anita Ida, Dominguez, Constanza Pía, Rodríguez, María Verónica, Batlla, Diego, García De Salamone, Inés E., Benech-Arnold, Roberto Luis, Andreani, Ana L.   +6 more
core   +1 more source

Leveraging Microphysiological Systems to Facilitate Neutrophil‐Based Cancer Immunotherapy

Advanced Science, EarlyView.
Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...
Shuai Shao, Markus Isfeld Diehl, Caroline N. Jones   +2 more
wiley   +1 more source

Pathological Signal‐Responsive Nanoplatforms for Sepsis: Integrating Biomarker Sensing With Spatiotemporal Drug Delivery and Immunomodulation

Advanced Science, EarlyView.
Biomarker‐triggered nanoplatforms transform sepsis therapy by coupling pathological sensing with precision drug release. This review reveals how microenvironment‐responsive nanomedicines enable stage‐specific intervention, improve therapeutic efficacy, and minimize systemic toxicity, while highlighting emerging opportunities for AI‐assisted and ...
Yukun Liu, Kang Wang, Kwet Kyawl Yan, Zhikai Xu, Xuan Zhao, Xiangjun Bai, Zhanfei Li, Yuchang Wang   +7 more
wiley   +1 more source

The Role of Microbial Dormancy in Soil Carbon-Climate Feedbacks

, 2017
Soil respiration, a process primarily driven by soil microbes, is the largest flux of carbon from terrestrial ecosystems to the atmosphere. As the Earth gets warmer, the annual amount of carbon that is respired from soil to the atmosphere is increasing ...
Salazar, Alejandro
core   +1 more source

Immunometabolic reprogramming in macrophages infected with active and dormant Cryptococcus neoformans: differential modulation of respiration, glycolysis, and fatty acid utilization

Infection and Immunity
Dormancy is an adaptation in which cells reduce their metabolism, transcription, and translation to stay alive under stressful conditions, preserving the capacity to reactivate once the environment reverts to favorable conditions.
Clara Luna Marina, Raffael J. Araújo de Castro, Paula Bellozi, Ana M. Cruz, Pedro Henrique Bürgel, Paul G. Weightman Potter, Craig Beall, Aldo Henrique Tavares, Andreza De Bem, Alexandre Alanio, Carolina Coelho, Anamélia Lorenzetti Bocca   +11 more
doaj   +1 more source

Dormancy

, 2008
Dormancy or torpor is a widely-recognized behavioral and physiological state of bothanimals and plants that generally indicates inactivity and reduced metabolic rate.
P. C. Withers (4575133), Christine Cooper (3276291)   +1 more
core  

Towards a Compositional Framework for Describing Human Phenotypes

Advanced Science, EarlyView.
The Phenotype Assembly Method (PhenoAM) decomposes phenotype variables into measurable Features and typed Qualifiers, enabling standardized, machine‐readable Phenome Data Elements (PhenoDEs) that preserve measurement context. Applied in the International Human Phenome Project (IHPP), the framework yields 58 371 PhenoDEs and supports component‐level ...
Wanting Hu, Yunchao Ling, Xinyue Hu, Wei Chen, Rong Zhou, Xinhao Zhuang, Yanfeng Jiang, Jialu Zhao, Xingdong Chen, Jingchun Luo, Li Jin, Guoqing Zhang   +11 more
wiley   +1 more source

Biogeography of photoautotrophs in the high polar biome

Frontiers in Plant Science, 2015
The global latitudinal gradient in biodiversity weakens in the high polar biome and so an alternative explanation for distribution of Arctic and Antarctic photoautotrophs is required. Here we identify how temporal, microclimate and evolutionary drivers
Stephen Brian Pointing, Burkhard eBuedel, Peter eConvey, Len eGillman, Christian eKoerner, Sebastian eLeuzinger, Warwick F. Vincent   +6 more
doaj   +1 more source

Microbial community development in a dynamic gut model is reproducible, colon region specific, and selective for Bacteroidetes and Clostridium cluster IX [PDF]

, 2010
Dynamic, multicompartment in vitro gastrointestinal simulators are often used to monitor gut microbial dynamics and activity. These reactors need to harbor a microbial community that is stable upon inoculation, colon region specific, and relevant to in ...
Marzorati, M., Sam Possemiers, Sahar El Aidy, Kleerebezem, M., Verstraete, Willy, Smidt, H., Marzorati, Massimo, Philippe Gérard, Rabot, S., Charlotte Grootaert, Verstraete, W., Aidy, S.F., El, Erwin Zoetendal, Hauke Smidt, Possemiers, Sam, Zoetendal, Erwin, Kleerebezem, Michiel, van der Wiele, T., Sylvie Rabot, Grootaert, C., Michiel Kleerebezem, Possemiers, S., Massimo Marzorati, Derrien, Muriel, Pieter Van den Abbeele, Tom Van de Wiele, Derrien, M.M.N., Rabot, Sylvie, Grootaert, Charlotte, van den Abbeele, P., Bruneau, A., Wiele, T., van der, Willy Verstraete, Zoetendal, E.G., El Aidy, Sahar, Gerard, Philippe, Abbeele, P., van den, Muriel Derrien, Smidt, Hauke, Van de Wiele, Tom, Gérard, P., Van den Abbeele, Pieter, Bruneau, Aurelia, El Aidy, S.F., Aurélia Bruneau   +44 more
core   +1 more source