Results 61 to 70 of about 380,519 (271)

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Exploring the microbial savanna: predator-prey interactions in the soil

Molecular Systems Biology
Soils host complex multi-trophic communities with diverse, mostly microbial, predator and prey species, including numerous bacterivorous protists and bacterial prey.
Laura Sanchis Pla, Jordi van Gestel
doaj   +1 more source

Methods used in microbial forensics and epidemiological investigations for stronger health systems

Forensic Sciences Research, 2022
This review discusses microbial forensics as an emerging science that finds application in protecting human health. It is important to distinguish naturally acquired infections from those caused by the intentional release of microorganisms to the ...
Arizaldo E. Castro, Maria Corazon A. De Ungria   +1 more
doaj   +1 more source

A biophysical model of prokaryotic diversity in geothermal hot springs

, 2008
Recent field investigations of photosynthetic bacteria living in geothermal hot spring environments have revealed surprisingly complex ecosystems, with an unexpected level of genetic diversity.
A. J. Watson, A. L. Koch, Anna Klales, C. L. Lehman, D. de Beer, D. M. Ward, D. M. Ward, D. Tilman, Elizabeth Janus Nett, J. K. Kristjansson, J. M. Chase, James Duncan, M. J. Ferris, M. J. Ferris, M. J. Ferris, M. R. Droop, M. T. Madigan, R. F. Ramaley, R. W. Castenholz, S. C. Nold, S. M. Sievert, Suzanne Amador Kane, T. D. Brock, T. D. Brock   +23 more
core   +1 more source

Clinical Practice Guideline for Evaluation and Management of Peripheral Nervous System Manifestations in Sjögren's Disease

Arthritis Care &Research, Accepted Article.
Objectives Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and autonomic nervous system neuropathies. To help patients and providers in the decision‐making process, we developed
Anahita Deboo, Robert Fox, Katherine M. Hammitt, Julie Frantsve‐Hawley, Matthew C. Baker, Stamatina Danielides, Eduardo De Sousa, Brent P. Goodman, Jennifer K. King, Steven Mandel, Ghaith Noaiseh, Pantelis P. Pavlakis, George Sarka, R. Hal Scofield, Arun Varadhachary, Daniel J. Wallace, Matt Makara, Nancy Carteron, Steven Carsons, In collaboration with the Consensus Expert Panel (CEP) members   +19 more
wiley   +1 more source

Tunable cell differentiation via reprogrammed mating-type switching

Nature Communications
This study introduces a synthetic biology approach that reprograms the yeast mating-type switching mechanism for tunable cell differentiation, facilitating synthetic microbial consortia formation and cooperativity. The underlying mechanism was engineered
Yu Chyuan Heng, Shohei Kitano, Adelia Vicanatalita Susanto, Jee Loon Foo, Matthew Wook Chang   +4 more
doaj   +1 more source

Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models

Advanced Functional Materials, EarlyView.
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen, Sabah Kasmi, Shrinivas Dumbre, Lies Baekens, Elise Seynaeve, Louise Van den Hauwe, Niccolò Cantini, Aello Garantoudi, Filipe Branco Madeira, Alain Marrot, Emma Tuypens, Sofie Seghers, Anna Kuchmiy, Elisabeth Brabants, Bart Vanderborght, Ine Maes, Sarah Vandenberghe, Jessica Filtjens, Alícia Gordún Peiró, Daliya Kancheva, Ayla Debraekeleer, Florence Lambolez, Emily De Lombaerde, Yong Chen, Rafael Miyazawa Martins, Pauline Formaglio, Damya Laoui, Sofie Deschoemaeker, Bruno G. De Geest, Rogerio Amino, Stefaan De Koker   +30 more
wiley   +1 more source

Synthetic control of a fitness tradeoff in yeast nitrogen metabolism

Journal of Biological Engineering, 2009
Background Microbial communities are involved in many processes relevant to industrial and medical biotechnology, such as the formation of biofilms, lignocellulosic degradation, and hydrogen production. The manipulation of synthetic and natural microbial
Lee Jack J, Beisel Chase L, Hoff Kevin G, Bayer Travis S, Smolke Christina D   +4 more
doaj   +1 more source

Spatial organization of the kelp microbiome at micron scales

Microbiome, 2022
Background Elucidating the spatial structure of host-associated microbial communities is essential for understanding taxon-taxon interactions within the microbiota and between microbiota and host. Macroalgae are colonized by complex microbial communities,
S. Tabita Ramírez-Puebla, Brooke L. Weigel, Loretha Jack, Cathleen Schlundt, Catherine A. Pfister, Jessica L. Mark Welch   +5 more
doaj   +1 more source

Ratiometric control for differentiation of cell populations endowed with synthetic toggle switches

, 2019
We consider the problem of regulating by means of external control inputs the ratio of two cell populations. Specifically, we assume that these two cellular populations are composed of cells belonging to the same strain which embeds some bistable memory ...
di Bernardo, Mario, Fiore, Davide, Salzano, Davide   +2 more
core   +1 more source