Results 81 to 90 of about 308,196 (199)
Developing Quorum Sensing‐Based Collaborative Dynamic Control System in Halomonas TD01
Advanced Science, EarlyView.A standardized and streamlined inducer‐free quorum sensing (QS)‐based collaborative dynamic control pattern is developed for sufficient gene expression control in Halomonas TD by mixing two engineered cells, cells A and B. Proof‐of‐concept studies are designed to test the dynamic control performance in mixed cultures in fed‐batch conditions.
Yi‐Na Lin +12 more
wiley +1 more source
Effect of drift, selection and recombination on the equilibrium frequency of deleterious mutations [PDF]
J. theor. Biol. 365, 238-246 (2015), 2013 We study the stationary state of a population evolving under the action of random genetic drift, selection and recombination in which both deleterious and reverse beneficial mutations can occur. We find that the equilibrium fraction of deleterious mutations decreases as the population size is increased.
arxiv
Advanced Science, EarlyView.Copper‐based nanoparticles doped with BSO, and modified with PEG, not only can it increase the retention ability and mucosal penetration ability in the lungs, but also induce cuproptosis‐like death in bacteria and inhibit bacterial TCA cycle. It can also inhibit bacterial quorum sensing, clear biofilms, reduce bacterial virulence, and thus exert ...
Huiqun Hu +9 more
wiley +1 more source
Predicting trajectories and mechanisms of antibiotic resistance evolution [PDF]
arXiv, 2020 Bacteria evolve resistance to antibiotics by a multitude of mechanisms. A central, yet unsolved question is how resistance evolution affects cell growth at different drug levels. Here we develop a fitness model that predicts growth rates of common resistance mutants from their effects on cell metabolism. We map metabolic effects of resistance mutations
arxiv
Advanced Science, EarlyView.This study presents an innovative oral microalgae‐based biosystem to inhibit tumor growth, reduce PD‐1 expression, and activate immune responses of hepatocellular carcinoma. When combined with enhanced irreversible electroporation treatment, it demonstrates a synergistic effect that effectively reduces the tumor burden and enhances the tumor immune ...
Cheng Zeng +8 more
wiley +1 more source
Viruses in sanctuary chimpanzees across Africa
American Journal of Primatology, Volume 85, Issue 1, January 2023., 2023 Abstract Infectious disease is a major concern for both wild and captive primate populations. Primate sanctuaries in Africa provide critical protection to thousands of wild‐born, orphan primates confiscated from the bushmeat and pet trades. However, uncertainty about the infectious agents these individuals potentially harbor has important implications ...
Emily Dunay +9 more
wiley +1 more source
Universal asymptotic clone size distribution for general population growth [PDF]
arXiv, 2016 Deterministically growing (wild-type) populations which seed stochastically developing mutant clones have found an expanding number of applications from microbial populations to cancer. The special case of exponential wild-type population growth, usually termed the Luria-Delbr\"uck or Lea-Coulson model, is often assumed but seldom realistic.
arxiv
Advanced Science, EarlyView.This study uses gut microbiome data to predict corticosteroid response in patients with immune thrombocytopenia (ITP). Fecal samples from 212 patients with ITP are sequenced. Six machine‐learning algorithms are used to train predictive models. The support vector machine‐based model integrated clinical data and selected microbial species, diversities ...
Feng‐Qi Liu +38 more
wiley +1 more source
International Forum of Allergy &Rhinology, Volume 13, Issue 1, Page 15-24, January 2023., 2023 Abstract Background Patients with chronic rhinosinusitis (CRS) may have persistence of polyps, discharge, or edema after endoscopic sinus surgery (ESS). Inflammation in CRS can be classified into three endotypes, with the presence of polyps associated with the type 2 endotype.
Eli Stein +12 more
wiley +1 more source
Phylogenetics and the human microbiome [PDF]
arXiv, 2014 The human microbiome is the ensemble of genes in the microbes that live inside and on the surface of humans. Because microbial sequencing information is now much easier to come by than phenotypic information, there has been an explosion of sequencing and genetic analysis of microbiome samples.
arxiv