Results 91 to 100 of about 8,071,040 (341)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Correction to: Biosynthesis and characterization of silver nanoparticles induced by fungal proteins and its application in different biological activities

Journal of Genetic Engineering and Biotechnology, 2020
In the publication of this article [1], the title of Figure 6 was missing. The original article has been corrected.
Abdelmageed M. Othman, Maysa A. Elsayed, Naser G. Al-Balakocy, Mohamed M. Hassan, Ali M. Elshafei   +4 more
doaj   +1 more source

Bioremediation of lignocellulosic wastes of food industries by Aspergillus flavus as food and feed additive protein by solid-state fermentation process [PDF]

Advances in Environmental Technology, 2017
The lignocellulosic wastes produced in food industries are suitable raw materials for the production of biological products. In this study, the solid state fermentation of Aspergillus flavus on lignocellulosic wastes was evaluated for microbial protein ...
Fatemeh Ardestani, Ali Shokuhi Rad
doaj   +1 more source

Expression systems for industrial Gram-positive bacteria with low guanine and cytosine content [PDF]

, 1997
Recent years have seen an increase in the development of gene expression systems for industrial Gram-positive bacteria with low guanine and cytosine content that belong to the genera Bacillus, Clostridium, Lactococcus, Lactobacillus, Staphylococcus and ...
Kleerebezem, Michiel,, Kuipers, Oscar P.,, Vos, Willem M. de,   +2 more
core   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Metabolic engineering of Yarrowia lipolytica for the production and secretion of the saffron ingredient crocetin

Biotechnology for Biofuels and Bioproducts
Background Crocetin is a multifunctional apocarotenoid natural product derived from saffron, holding significant promises for protection against various diseases and other nutritional applications.
Tingan Zhou, Young-Kyoung Park, Jing Fu, Piotr Hapeta, Cinzia Klemm, Rodrigo Ledesma-Amaro   +5 more
doaj   +1 more source

Small and mighty: adaptation of superphylum Patescibacteria to groundwater environment drives their genome simplicity. [PDF]

, 2020
BackgroundThe newly defined superphylum Patescibacteria such as Parcubacteria (OD1) and Microgenomates (OP11) has been found to be prevalent in groundwater, sediment, lake, and other aquifer environments.
Adams, Benjamin G, Alm, Eric J, Arkin, Adam P, Detienne, Brittny L, Fields, Matthew W, Gao, Shuhong, Hazen, Terry C, He, Zhili, Joyner, Dominique C, Klingeman, Dawn M, Lowe, Kenneth A, Ning, Daliang, Rocha, Andrea M, Shi, Weiling, Spencer, Sarah J, Stahl, David A, Tian, Renmao, Wu, Linwei, Yang, Yunfeng, Zhang, Ping, Zhang, Ya, Zhou, Jizhong   +21 more
core   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Genome sequencing and annotation of Laceyella sacchari strain GS 1-1, isolated from hot spring, Chumathang, Leh, India

Genomics Data, 2014
We report the 3.3-Mb draft genome of Laceyella sacchari strain GS 1-1, isolated from hot spring water sample, Chumathang, Leh, India. Draft genome of strain GS 1-1 consists of 3, 324, 316 bp with a G + C content of 48.8% and 3429 predicted protein coding
Navjot Kaur, Amit Arora, Narender Kumar, Shanmugam Mayilraj   +3 more
doaj   +1 more source