Results 131 to 140 of about 154,475 (311)

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

open access: yesAdvanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen   +19 more
wiley   +1 more source

Molecular detection of genes encoding AcrAB , Qep A efflux pumps in Klebsiella pneumoniae strains isolated from hospitalized patients in selected hospitals in Tehran

open access: yesMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2017
Background and Objectives: Increasing emergence of fluoroquinolone resistance among clinical isolates of Klebsiella pneumoniae  (K. pneumoniae), has limited the treatment options for treatment of infections caused by these bacteria.
Mohsen Heidary   +5 more
doaj  

Iron‐Mediated Release of Aged Dissolved Organic Carbon From Waterlogged Peatland Under Warming

open access: yesAdvanced Science, EarlyView.
This study conducts a five‐year in situ warming experiment in high‐altitude peatlands to examine dissolved organic carbon (DOC) release. The study shows that warming promotes the release of plant‐derived modern DOC in drained peatlands, but amplifies aquatic export of century‐old DOC from waterlogged peatlands via Fe‐mediated DOC mobilization—a ...
Guohua Dai   +18 more
wiley   +1 more source

Amuc_1473 Links Gut Microbes to Skeletal Homeostasis and Counteracts Multifactorial Osteoporosis

open access: yesAdvanced Science, EarlyView.
Amuc_1473, a previously uncharacterized protein enriched in Akkermansia muciniphila‐derived extracellular vesicles, is identified as a gut–bone messenger that promotes osteogenesis and inhibits osteoclastogenesis by engaging transcriptional and translational regulators in bone cells.
Shan‐Shan Rao   +28 more
wiley   +1 more source

Human‐Centered Innovation: Precision Nutrition and the Future of Food

open access: yesAdvanced Science, EarlyView.
ABSTRACT Nutritional science is moving beyond one‐size‐fits‐all recommendations toward more precise and personalized approaches, yet its implementation pathway remains unclear. This paper proposes a human‐centered precision nutrition framework that highlights the central roles of artificial intelligence (AI), food innovation, and human agency.
Shanshan Zhang   +3 more
wiley   +1 more source

Gut Microbiota, Immunity, and Metabolism in the Progression From Chronic Liver Disease to Hepatocellular Carcinoma

open access: yesAdvanced Science, EarlyView.
This review explains how chronic liver injury progresses toward hepatocellular carcinoma through interconnected changes in gut microbes, metabolism, immunity, fibrosis, and diet. It highlights microbial metabolites, bile‐acid signaling, immune dysfunction, and nutritional or microbiome‐based interventions as opportunities to identify risk earlier ...
Yi Hu   +5 more
wiley   +1 more source

The inhibitory effects of carvacrol, nystatin, and their combination on oral candidiasis isolates

open access: yesBMC Research Notes
Background Candida, a common oral microbiota, can cause opportunistic fungal infections. With rising Candida infections and limited effective antifungals, new treatments are needed.
Seyed Saeed Hosseini Balef   +4 more
doaj   +1 more source

Biofouling and its control for in situ lab-on-a-chip marine environmental sensors [PDF]

open access: yes, 2012
Biofouling is the process by which biological organisms attach to surfaces in an aqueous environment. This occurs on nearly all surfaces in all natural aquatic environments, and can cause problems with the functioning of scientific equipment exposed to ...
Walker, David
core  

Highly Flexible and Conformable ZnO/FeGa Magnetoelectric Heterostructures for Skin wound Healing

open access: yesAdvanced Science, EarlyView.
The magnetic field‐induced electric field generated by a highly flexile ZnO(piezoelectric)/FeGa(magnetostrictive) magnetoelectric heterostructure embedded in the low Young's modulus elastomer PDMS has been used to stimulate the wound healing processes.
Filippos Perdikos   +17 more
wiley   +1 more source

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