Results 161 to 170 of about 919,747 (358)

Small RNA Toxin‐Assisted Evolution of GC‐Preferred ErCas12a for Enhanced Genome Targeting Range

Advanced Science, EarlyView.
ErCas12a is engineered to target GC‐rich PAMs using a small RNA toxin‐aided positive screening system. The resulting variant, enErCas12a, exhibits an expanded PAM profile and facilitates efficient gene editing in both bacterial and mammalian cells, while preserving high targeting specificity for both canonical and non‐canonical PAM targets.
Zehua Chen, Junyuan Xue, Ziying Wang, Jinyuan Sun, Yinglu Cui, Tong Zhu, Huaiyi Yang, Ming Li, Bian Wu   +8 more
wiley   +1 more source

Metagenomic next generation sequencing improves diagnosis of prosthetic joint infection by detecting the presence of bacteria in periprosthetic tissues

International Journal of Infectious Diseases, 2020
Objectives: The purpose of this study was to explore the role of mNGS in the diagnosis of PJI by detecting the presence of bacteria in periprosthetic tissues.
Yuanqing Cai, Xinyu Fang, Yang Chen, Zida Huang, Chaofan Zhang, Wenbo Li, Bin Yang, Wenming Zhang   +7 more
doaj  

Microbial ecology of Thiobacillus ferrooxidans [PDF]

, 1990
FINAL TECHNICAL REPORT TO U.S. DEPARTMENT OF THE INTERIOR Geological Survey Washington. D.C.The contents of this report were developed in part under a grant from the Department of the Interior, U.S. Geological Survey.
Braddock, Joan F., Brown, Edward J., Dixon, David P., Hong, Seongho, Luong, Huan V., Rasley, Brian T.   +5 more
core  

Red Blood Cell‐Induced Bacterial Margination Improves Microbial Hemoadsorption on Engineered Cell‐Depleted Thrombi, Restoring Severe Bacteremia in Rats

Advanced Science, EarlyView.
A highly efficient extracorporeal device for treating bacteremia is developed by integrating microfluidic bacterial margination and engineered cell‐depleted thrombi strategically constructed in the device. The rodent models, severely infected with antibiotic‐resistant bacteria, recover from bacteremia after two subsequent extracorporeal blood ...
Bong Hwan Jang, Su Hyun Jung, Seyong Kwon, Sung Jin Park, Joo H. Kang   +4 more
wiley   +1 more source

Battery‐Free, Stretchable, and Autonomous Smart Packaging

Advanced Science, EarlyView.
This article reports the development of a battery‐free, autonomous smart packaging system that integrates real‐time food monitoring through a gas sensor, a Near‐Field Communication (NFC) antenna, and a controlled release of active compounds. The system effectively extends food shelf‐life by up to 14 days, demonstrating its potential to preserve food ...
Ali Douaki, Mukhtar Ahmed, Edoardo Longo, Giulia Windisch, Raheel Riaz, Sarwar Inam, Thi Nga Tran, Evie L. Papadopoulou, Athanassia Athanassiou, Emanuele Boselli, Luisa Petti, Paolo Lugli   +11 more
wiley   +1 more source

Engineered Tissue Models to Decode Host–Microbiota Interactions

Advanced Science, EarlyView.
Host–Microbiota interactions in the human body. Created in BioRender. Ghezzi, C. (2025) https://BioRender.com/ihivskg. Abstract A mutualistic co‐evolution exists between the host and its associated microbiota in the human body. Bacteria establish ecological niches in various tissues of the body, locally influencing their physiology and functions, but ...
Miryam Adelfio, Grace E. Callen, Xuesong He, Bruce J. Paster, Hatice Hasturk, Chiara E. Ghezzi   +5 more
wiley   +1 more source

A Phase‐Separated SR Protein Reprograms Host Pre‐mRNA Splicing to Enhance Disease Susceptibility

Advanced Science, EarlyView.
This study identifies SR30, a splicing factor, as a negative regulator of tomato immunity. During Phytophthora infestans infection, the elevated SR30 forms nuclear condensates to suppress the alternative splicing (AS) of defense‐related genes in a phase separation manner.
Dong Yan, Jie Huang, Fengqi Tian, Haidong Shu, Han Chen, Qian Peng, Hongwei Wu, Jianlong Zhao, Anireddy S. N. Reddy, Gang Li, Yuanchao Wang, Suomeng Dong   +11 more
wiley   +1 more source

Identification of CD38high Monocyte as a Candidate Diagnostic Biomarker and Therapeutic Target for Sepsis

Advanced Science, EarlyView.
This study uncovers that CD38high monocytes discriminate sepsis and sterile inflammation and are associated with 28‐day mortality in bacterial sepsis. Targeting CD38 therapy reduces inflammatory response in monocytes and in sepsis mice model. Mechanistically, CD38‐HIF‐1α/glycolysis/MGO loop exacerbates sepsis‐induced immune dysregulation.
Ning Hua, Limin Kong, Li Fan, Yanan Bai, Yujun Zhou, Yanfang Zhang, Qingwei Zhao, Xiaoyang Lu, Hongyu Yang, Hangyang Li, Peili Ding, Yuyu Nan, Qinghua Ji, Ping Yang, Lu Li, Yijing Xin, Lijuan Zhao, Wei Yang, Wenqiao Yu, Saiping Jiang   +19 more
wiley   +1 more source

Hydrogel‐Transformable Probiotic Powder for Targeted Eradication of Helicobacter pylori with Enhanced Gastric Mucosal Repair and Microbiota Preservation

Advanced Science, EarlyView.
A multifunctional, edible, and hydrogel‐transformable probiotic powder is developed based on the “bacteria‐mediated bacterial eradication” strategy. By leveraging the targeted binding capability of L. reuteri to H. pylori, this approach achieves an integrated therapeutic effect, including bactericidality, anti‐inflammation, gastric mucosal repair, and ...
Yongkang Lai, Hanchun Shen, Shige Wang, Yongliang Ouyang, Xinyuan Zhang, Bin Hu, Xiaoyi Zhang, Guisheng Li, Lizhi Xu, Jiulong Zhao   +9 more
wiley   +1 more source

A solid phase enzyme-linked immunosorbent assay for the antigenic detection of Legionella pneumophila (serogroup 1): A compliment for the space station diagnostic capability [PDF]

It is necessary that an adequate microbiology capability be provided as part of the Health Maintenance Facility (HMF) to support expected microbial disease events and environmental monitoring during long periods of space flight.
Hejtmancik, Kelly E.
core   +1 more source