Microbiota as diagnostic biomarkers: advancing early cancer detection and personalized therapeutic approaches through microbiome profiling. [PDF]
Eslami M+6 more
europepmc +1 more source
Akkermansia depletion correlates with acute pancreatitis (AP) severity. A. muciniphila and its protein Amuc_1409 mitigate pancreatic/systemic inflammation by expanding Tregs and IL‐10. Mechanistically, Amuc_1409 binds Ube2k, inhibiting Foxp3 ubiquitination to stabilize Treg differentiation and IL‐10 production, countering SAP‐induced SIRS/CARS ...
Jinyan Xie+9 more
wiley +1 more source
Identification of Naturally Occurring Inhabitants of Vaginal Microbiota in Cows and Determination of Their Antibiotic Sensitivity. [PDF]
Várhidi Z+5 more
europepmc +1 more source
Microbial Biosensor for Sensing and Treatment of Intestinal Inflammation
The engineered calprotectin biosensor detects gut inflammation, processes the signal through genetic regulation, and responds by expressing the reporter sfGFP and the therapeutic protein secIL10. This dual functionality enables the engineered biosensor not only to sense but also to mitigate gut inflammation, highlighting its potential for disease ...
Duolong Zhu+8 more
wiley +1 more source
The impact of gut microbiome modulation on anthropometric indices in metabolic syndrome: an umbrella review. [PDF]
Aleali MS+14 more
europepmc +1 more source
Multi‐Omics and ‐Organ Insights into Energy Metabolic Adaptations in Early Sepsis Onset
This study shows that patients at risk of sepsis have a distinct metabolite and lipid signature, including serine and aminoadipic acid, in their serum before clinical diagnosis. A mouse model of sepsis with a compatible serum signature reveals underlying metabolic changes, including mitochondrial adaptation, altered serine‐dependent purine metabolism ...
Lin‐Lin Xu+9 more
wiley +1 more source
Metagenomic next-generation sequencing of alveolar lavage fluid improves the detection of pulmonary infection. [PDF]
Meng Z, Li D, Yang W, Tang J.
europepmc +1 more source
Carbon nanosol (CNS) exhibits rapid root penetration capacity, enhancing plant growth through boosting stomatal density and antioxidative enzyme activity. Single‐cell transcriptomic profiling uncovers cell type‐specific gene expression patterns and developmental trajectories during CNS‐mediated growth promotion.
Lingtong Cheng+10 more
wiley +1 more source
A comprehensive evaluation of plasma metagenomics sequencing for the diagnosis of suspected infection in pediatric patients with hematologic diseases. [PDF]
Zhang S, Guo Q, Gai W, Guo Y, Zheng Y.
europepmc +1 more source