Construction of Chronic Kidney Disease Mouse Model Induced by Diets With Different Adenine Content
By administering a 4 weeks adenine diet to C57BL/6J mice, we identified 0.2% adenine in purified feed as the optimal chronic kidney disease model. This model induces severe renal damage, gut dysbiosis, uremic toxin accumulation, and CKD mineral bone disorder, providing a clinically relevant platform for mechanistic and therapeutic studies.
Wanjun Liao +8 more
wiley +1 more source
Fecal microbiome predicts treatment response after the initiation of semaglutide or empagliflozin uptake. [PDF]
Klemets A +5 more
europepmc +1 more source
ABSTRACT Underground gas storage is a cornerstone technology for addressing climate change and advancing the clean energy transition. By managing greenhouse gas emissions and enhancing energy system resilience, it supports global sustainability goals.
Sara Roces +5 more
wiley +1 more source
Investigation of the role of sulfide oxidation in the gill-associated microbiota of freshwater mussel <i>Limnoperna fortunei</i>. [PDF]
Peng Y +16 more
europepmc +1 more source
Role of vulvovaginal infection in women with short cervix: An observational clinical trial
Abstract Objective Short cervix (SC) and vulvovaginal infections, such as bacterial vaginosis (BV) and vulvovaginal candidosis (VVC), are known risk factors for preterm birth (PTB). The objective of this study was to investigate whether the combined presence of SC and vulvovaginal infections further elevates the risk of PTB.
Fanny Mikula +5 more
wiley +1 more source
Integrative analysis of rumen microbiota and host multi-organ interactions underlying feed conversion efficiency in Hu sheep. [PDF]
Jia X +7 more
europepmc +1 more source
Oat β‐glucan and galactooligosaccharides influence the formation of gallstones by modulating the gut microbiota, particularly the abundance of Desulfovibrionales. The primary mechanism involves metabolic byproducts associated with Desulfovibrionales inhibiting hepatic bile acid synthesis via both the hepatic FXR–SHP and intestinal FXR–FGF15 signaling ...
Liang Tian +20 more
wiley +1 more source
Genome-Resolved Approach of Guerrero Negro Hypersaline Microbial Mats Reveals the Metabolic Potential of Key Players in a Stratified Community. [PDF]
Martínez-Mercado MA +5 more
europepmc +1 more source
The occurrence and progression of colorectal cancer are intricately linked to metabolites produced by the gut microbiota. Metabolites generated by pathogenic microbial communities can promote colorectal cancer development by reshaping the immune microenvironment.
Xinrui Yang +3 more
wiley +1 more source
Sulfide Production and Microbial Dynamics in the Water Reinjection System from an Offshore Oil-Producing Platform. [PDF]
Domingues VDSP +5 more
europepmc +1 more source

