Bacterial toxins induce non-canonical migracytosis to aggravate acute inflammation
Cell DiscoveryMigracytosis is a recently described cellular process that generates and releases membrane-bound pomegranate-like organelles called migrasomes. Migracytosis normally occurs during cell migration, participating in various intercellular biological ...
Diyin Li +5 more
doaj +1 more source
Microbial correlation: a semi-parametric model for investigating microbial co-metabolism [PDF]
arXivThe gut microbiome plays a crucial role in human health, yet the mechanisms underlying host-microbiome interactions remain unclear, limiting its translational potential. Recent microbiome multiomics studies, particularly paired microbiome-metabolome studies (PM2S), provide valuable insights into gut metabolism as a key mediator of these interactions ...
arxiv
Advanced Science, EarlyView.We developed a citramalate‐derived pathway for 2‐methylbutyric acid production in E. coli mono‐culture and consortia. The optimized consortium, using 2‐keto‐3‐methylvalerate as a node, achieved 1817.03 ± 103.73 mg L−1 2‐methylbutyric acid, a 28‐fold increase from the initial strain, with a yield of 0.091 g/g glucose.
Yu Liu +3 more
wiley +1 more source
Small RNA Toxin‐Assisted Evolution of GC‐Preferred ErCas12a for Enhanced Genome Targeting Range
Advanced Science, EarlyView.ErCas12a is engineered to target GC‐rich PAMs using a small RNA toxin‐aided positive screening system. The resulting variant, enErCas12a, exhibits an expanded PAM profile and facilitates efficient gene editing in both bacterial and mammalian cells, while preserving high targeting specificity for both canonical and non‐canonical PAM targets.
Zehua Chen +8 more
wiley +1 more source
Bioconvection and Bloom in Porous environment and Its Assisted Technologies: A Review [PDF]
arXivBioconvection, a phenomenon arising from the collective motion of motile microorganisms, plays a crucial role in shaping microbial distributions, fluid dynamics, and bloom formation in aquatic environments. While extensive research has explored bioconvection in open waters, a significant proportion of microbial life exists within porous habitats ...
arxiv
Gut Microbial Shifts By Synbiotic Combination of Pediococcus Acidilactici and Lactulose In Weaned Piglets Challenged With Shiga Toxin-Producing Escherichia coli [PDF]
, 2021 Robin B. Guevarra +14 more
openalex +1 more source
Engineered Probiotics Mitigate Gut Barrier Dysfunction Induced by Nanoplastics
Advanced Science, EarlyView.Intestinal barrier stability is vital for gut health. Plastic polyethylene terephthalate (PET) disrupts this barrier, causing inflammation and infections. This study encodes transforming growth factor‐β into EcN and modifies its surface with pH‐responsive polymer (EcNT@L), creating an oral drug delivery system to repair nano PET‐induced intestinal ...
Wenxin Chen +9 more
wiley +1 more source
Engineered Tissue Models to Decode Host–Microbiota Interactions
Advanced Science, EarlyView.Host–Microbiota interactions in the human body. Created in BioRender. Ghezzi, C. (2025) https://BioRender.com/ihivskg. Abstract A mutualistic co‐evolution exists between the host and its associated microbiota in the human body. Bacteria establish ecological niches in various tissues of the body, locally influencing their physiology and functions, but ...
Miryam Adelfio +5 more
wiley +1 more source
Development and validation of ultra-high-performance liquid chromatography-tandem mass spectrometry methods for the simultaneous determination of beauvericin, enniatins (A, A1, B, B1) and cereulide in maize, wheat, pasta and rice [PDF]
, 2016 De Saeger, Sarah +4 more
core +1 more source