Results 51 to 60 of about 1,010,901 (360)

Thrombolome and Its Emerging Role in Chronic Kidney Diseases

Toxins, 2021
Patients with chronic kidney disease (CKD) are at an increased risk of thromboembolic complications, including myocardial infarction, stroke, deep vein thrombosis, and pulmonary embolism. These complications lead to increased mortality.
Justyna Fryc, Beata Naumnik
doaj   +1 more source

Diversity and biosynthetic potential of culturable microbes associated with toxic marine animals [PDF]

, 2013
Tetrodotoxin (TTX) is a neurotoxin that has been reported from taxonomically diverse organisms across 14 different phyla. The biogenic origin of tetrodotoxin is still disputed, however, TTX biosynthesis by host-associated bacteria has been reported.
Chau, Rocky, Kalaitzis, John, Neilan, Brett, Wood, Susanna A.   +3 more
core   +4 more sources

Ezrin enhances line tension along transcellular tunnel edges via NMIIa driven actomyosin cable formation

Nature Communications, 2017
Holes in endothelial barriers, called transendothelial cell macroapertures (TEMs), are predicted to be limited by line tension of unknown origin. Here the authors identify an actomyosin cable encircling TEMs and establish a role for ezrin in stabilising ...
Caroline Stefani, David Gonzalez-Rodriguez, Yosuke Senju, Anne Doye, Nadia Efimova, Sébastien Janel, Justine Lipuma, Meng Chen Tsai, Daniel Hamaoui, Madhavi P. Maddugoda, Olivier Cochet-Escartin, Coline Prévost, Frank Lafont, Tatyana Svitkina, Pekka Lappalainen, Patricia Bassereau, Emmanuel Lemichez   +16 more
doaj   +1 more source

RhoGTPases and inflammasomes: Guardians of effector-triggered immunity.

PLoS Pathogens, 2021
Pathogens have evolved smart strategies to invade hosts and hijack their immune responses. One such strategy is the targeting of the host RhoGTPases by toxins or virulence factors to hijack the cytoskeleton dynamic and immune processes.
Océane Dufies, Laurent Boyer
doaj   +1 more source

Protective Microbiota: From Localized to Long-Reaching Co-Immunity [PDF]

, 2017
Resident microbiota do not just shape host immunity, they can also contribute to host protection against pathogens and infectious diseases. Previous reviews of the protective roles of the microbiota have focused exclusively on colonization resistance ...
Abt, Abt, Algburi, Altenhoefer, Altier, Anderson, Annuk, Asahara, Ashburner, Ayabe, Ayres, Barr, Barton, Bassis, Bassler, Becattini, Belkaid, Belkaid, Belkaid, Belkaid, Benson, Benveniste, Berg, Bevins, Birchenough, Birchenough, Blackburn, Bocci, Bohnhoff, Botes, Bouskra, Brandl, Braniste, Brenchley, Brestoff, Britton, Bron, Brugiroux, Budden, Buddington, Buffie, Buffie, Cani, Cani, Carey, Cash, Castagliuolo, Catford, Cebra, Cerf-Bensussan, Chatzidaki-Livanis, Chen, Chow, Chudnovskiy, Clarke, Clarke, Clarke, Cogen, Cogen, Cogen, Cotar, Cremer, Crost, Danielsson, Davidson, Davis, de Agüero, de Sablet, de Steenhuijsen Piters, Delhaes, Denny, Deriu, Dickson, Dickson, Dickson, Dickson, Donaldson, Donnet-Hughes, Eberl, El-Solh, Everett, Fagundes, Fardini, Fine, Fransen, Frantz, Franzenburg, Freter, Freter, Freter, Freter, Freter, Fubara, Fukuda, Gabryszewski, Gallichan, Gallo, Ganal, Gantois, Gauguet, Geva-Zatorsky, Gill, Gorjifard, Gutzeit, Henao-Mejia, Hersoug, Hibbing, Hooper, Hooper, Hooper, Hsiao, Ichinohe, Irie, Ivanov, Ivanov, Iwase, Kamada, Khosravi, Kinnunen, Knoop, Koch, Kolling, Kommineni, Laurent, Lawley, Levine, Little, Mack, Macpherson, Macpherson, Macpherson, Macpherson, Majlessi, Mallon, Maltby, Man, Mantis, Martins, Masson, Mazmanian, Mazmanian, McAleer, McKenney, Medzhitov, Melo, Mishra, Molloy, Murall, Mushin, Nagy, Nikkari, Oldroyd, Olier, Palm, Pamer, Pang, Perry, Pfeiffer, Pontier-Bres, Pradeu, Pradeu, Pradeu, Pérez-Santiago, Qin, Ramanan, Rasmussen, Rea, Rea, Ripert, Rizzetto, Robinson, Rolfe, Roossinck, Round, Ruhe, Råberg, Salzman, Sambanthamoorthy, Samuelson, Santagati, Santagati, Sassone-Corsi, Sassone-Corsi, Savage, Schamberger, Schieber, Schneider, Schuijt, Sharma, Shi, Shin, Shokouhfard, Shu, Siegrist, Soares, Sommer, Spees, Stapleton, Stappenbeck, Stecher, Stecher, Stinson, Strugnell, Sutyak Noll, Tanaka, Theriot, Tillmann, Tomkovich, Tomás, Tuomola, Ubeda, Underhill, Vaishnava, Valdés-Varela, Valdés-Varela, Valle, Van de Perre, van der Waaij, Vandecandelaere, Venkataraman, Villarino, Virgin, Virgin, Walker, Walsham, Weaver, Weingarden, Wexler, Whiteson, Wikoff, Willis, Wootton, Wright, Wu, Xiang, Yilmaz, Zagato, Zeng, Zipperer   +238 more
core   +3 more sources

Review of mycotoxin reduction in food and feed: from prevention in the field to detoxification by adsorption or transformation [PDF]

, 2011
Mycotoxins are secondary metabolites present worldwide in agricultural commodities and produced by filamentous fungi that cause a toxic response (mycotoxicosis) when ingested by animals.
Guyonvarc’h, Alain, Jard, Gwénaëlle, Lebrihi, Ahmed, Liboz, Thierry, Mathieu, Florence   +4 more
core   +2 more sources

Innate immunity: ignored for decades, but not forgotten. [PDF]

, 2012
The innate immune system must recognize and rapidly respond to microbial pathogens, providing a first line of host defense. This is accomplished through an array of pattern recognition receptors (PRRs) that reside in specific subcellular compartments and
Adam, Alexopoulou, Blander, Brightbill, Busch, Coley, Coley, Davis, Diebold, Doyle, Doyle, Eisenbarth, Ellouz, Fehleisen, Ferwerda, Freund, Girardin, Girardin, Glenny, Gresser, Hansen, Hayashi, Hemmi, Hemmi, Inohara, Janeway, Kleinerman, Krutzik, Lai, Lande, Langerhans, Lewis, Liu, Liu, Liu, Martinon, Martinon, Medzhitov, Metchnikoff, Modlin, Morales, Morton, Pollack, Poltorak, Ramon, Ramon, Robert L. Modlin, Schauber, Specter, Sugimoto, Terhorst, Thoma-Uszynski, Watanabe, Yang   +53 more
core   +1 more source

Colorectal cancer: the facts in the case of the microbiota

The Journal of Clinical Investigation, 2022
The importance of the microbiota in the development of colorectal cancer (CRC) is increasingly evident, but identifying specific microbial features that influence CRC initiation and progression remains a central task for investigators.
Slater L. Clay, Diogo Fonseca-Pereira, Wendy S. Garrett   +2 more
doaj   +1 more source

Amoebae as Targets for Toxins or Effectors Secreted by Mammalian Pathogens

Toxins, 2021
Numerous microorganisms, pathogenic for mammals, come from the environment where they encounter predators such as free-living amoebae (FLA). The selective pressure due to this interaction could have generated virulence traits that are deleterious for ...
Ascel Samba-Louaka
doaj   +1 more source

Toxin-mediated competition in weakly motile bacteria [PDF]

2019, J. Theor. Biol. 480 , 205-217, 2019
Many bacterial species produce toxins that inhibit their competitors. We model this phenomenon by extending classic two-species Lotka-Volterra competition in one spatial dimension to incorporate toxin production by one species. Considering solutions comprising two adjacent single-species colonies, we show how the toxin inhibits the susceptible species ...
arxiv   +1 more source