Identification of the Microbial Transformation Products of Secoisolariciresinol Using an Untargeted Metabolomics Approach and Evaluation of the Osteogenic Activities of the Metabolites [PDF]
Molecules, 2023 Secoisolariciresinol (SECO) is one of the major lignans occurring in various grains, seeds, fruits, and vegetables. The gut microbiota plays an important role in the biotransformation of dietary lignans into enterolignans, which might exhibit more potent
Wen-Xuan Yu +17 more
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Microbial Transformation and Biological Activities of the Prenylated Aromatic Compounds from Broussonetia kazinoki [PDF]
Molecules, 2022 Broussonetia kazinoki has been used as a traditional medicine for the treatment of burns and acne, and its extracts have been found to show tyrosinase inhibitory and anticancer activities. In this study, the tyrosinase inhibitory and cytotoxic activities
EunA Choi +3 more
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Effects of Microbial Transformation on the Biological Activities of Prenylated Chalcones from Angelica keiskei [PDF]
Foods, 2022 Microbial transformation is an alternative method for structural modification. The current study aimed at application of microbial transformation for discovering new derivatives and investigating the structure-activity relationship of isobavachalcone (1),
Yina Xiao, Ik-Soo Lee
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Evaluation of Microbial Transformation of 10-deoxoartemisinin by UPLC-ESI-Q-TOF-MSE [PDF]
Molecules, 2019 10-deoxoartemisinin is a semisynthetic derivative of artemisinin that lacks a lactone carbonyl group at the 10-position, and has stronger antimalarial properties than artemisinin.
Yue Bai +6 more
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Microbial Transformation of Flavonoids by Isaria fumosorosea ACCC 37814 [PDF]
Molecules, 2019 Glycosylation is an efficient strategy to modulate the solubility, stability, bioavailability and bioactivity of drug-like natural products. Biological methods, such as whole-cell biocatalyst, promise a simple but highly effective approach to glycosylate
Fangmin Dou +3 more
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A Microbial Transformation Model for Simulating Mammal Metabolism of Artemisinin [PDF]
Molecules, 2019 Artemisinin (ART) is a highly effective antimalarial agent isolated from the traditional Chinese herb Qinghao. Metabolism of ART and its derivatives in the body is one of the most pressing issues for pharmaceutical scientists.
Yue Ma +7 more
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The function of small RNA in Pseudomonas aeruginosa [PDF]
PeerJ, 2022 Pseudomonas aeruginosa, the main conditional pathogen causing nosocomial infection, is a gram-negative bacterium with the largest genome among the known bacteria.
Pei Liu +7 more
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The development and application of pseudoviruses: assessment of SARS-CoV-2 pseudoviruses [PDF]
PeerJ, 2023 Although most Coronavirus disease (COVID-19) patients can recover fully, the disease remains a significant cause of morbidity and mortality. In addition to the consequences of acute infection, a proportion of the population experiences long-term adverse ...
Conglian Tan +6 more
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Research Progress of Rare Carbohydrate Prebiotics
Shipin gongye ke-ji, 2023 Rare sugars are a kind of prebiotics with special chemical structure and bioactivities such as regulate intestinal flora, inhibit pathogen, resist oxidation, improve immunity, antitumor and so on.
Zilong ZHANG +9 more
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Zunyimycin C enhances immunity and improves cognitive impairment and its mechanism
Frontiers in Cellular and Infection Microbiology, 2022 This study aimed to explore the efficacy of zunyimycin C in the immunological enhancement of hypoimmune mice and improvement of cognitive impairment in a mice model of Alzheimer’s disease (AD). Zunyimycin C was administered intranasally to interfere with
Xuemei Wang +16 more
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