Results 301 to 310 of about 2,361,721 (335)

Microbial Primer: Artificial intelligence for microbiologists. [PDF]

Microbiology (Reading)
Cao H, de la Fuente-Nunez C.
europepmc   +1 more source

Influence of PER-7 on cefiderocol susceptibility in clinical isolates of <i>Acinetobacter baumannii</i> producing OXA-23 or OXA-72 carbapenemases. [PDF]

JAC Antimicrob Resist
Turowski P, Cremanns M, Eisfeld J, Gatermann S, Pfennigwerth N.   +4 more
europepmc   +1 more source

High‐Throughput Synthesis and Screening of a Cyanimide Library Identifies Selective Inhibitors of ISG15‐Specific Protease mUSP18

Angewandte Chemie, EarlyView.
Deubiquitinases (DUBs) and Ub‐like proteases are attractive but challenging drug targets. We developed a high‐throughput synthesis method and prepared a 7536‐member cyanimide DUB‐targeted compound library in 1536‐well plates, using Echo acoustic dispensing. Screening yielded a selective, 35 nM inhibitor of mUSP18, the main ISG15 protease.
Raymond Kooij, Vito Pol, Jin Gan, Bjorn R. van Doodewaerd, Aysegul Sapmaz, Marta Campos Alonso, Günter Fritz, Klaus‐Peter Knobeloch, Paul P. Geurink   +8 more
wiley   +1 more source

Complete genome of <i>Listeria aquatica</i> strain MRL-25-00004 from a cheese ripening environment in Austria. [PDF]

Microbiol Resour Announc
Daza Prieto B, Ladstaetter J, Murer A, Lennkh A, Ruppitsch W, Pietzka AT.   +5 more
europepmc   +1 more source

Microbiology and outcomes of tubo-ovarian abscesses: A 5-year cohort of 105 cases

Giulia Micheli, Guillaume Parpex, Asmaa Tazi, Elena Holeindre, Julien Loubinoux, Cécile Guyonnet, Jeanne Reboul‐Marty, Claire Poyart, Charles Chapron, Pauline Richebé, Étienne Canouï, Roberto Cauda, Martin Belan, Camille Rasmussen, Louis Marcellin, Laetitia Campin, Caroline Charlier   +16 more
openalex   +1 more source

De Novo Design of High‐Affinity Miniprotein Binders Targeting Francisella Tularensis Virulence Factor

Angewandte Chemie, EarlyView.
Hybrid physics and deep‐learning enabled design methods identified miniprotein binders to Flpp3 (Francisella‐like lipoprotein), a key virulence factor from Francisella tularensis. Multiple candidates with nanomolar to picomolar binding affinities were obtained using yeast surface display screening and further experimental optimization.
Gizem Gokce‐Alpkilic, Buwei Huang, Andi Liu, Lieselotte S.M. Kreuk, Yaxi Wang, Victor Adebomi, Yensi Flores Bueso, Asim K. Bera, Alex Kang, Stacey R. Gerben, Stephen Rettie, Dionne K. Vafeados, Nicole Roullier, Inna Goreshnik, Xinting Li, David Baker, Joshua J. Woodward, Joseph D. Mougous, Gaurav Bhardwaj   +18 more
wiley   +1 more source

Effectiveness of Game-Based Learning Versus Problem-Based Learning Approaches in Teaching Microbiology to Phase II Medical Students. [PDF]

Cureus
R S, Jacob N, Basheer S, Vidyalakshmi, Mr V.   +4 more
europepmc   +1 more source

Targeting Aurora Kinases as Essential Cell‐Cycle Regulators to Deliver Multi‐Stage Antimalarials Against Plasmodium Falciparum

Angewandte Chemie, EarlyView.
In this study, we repurposed human Aurora kinase‐specific inhibitors to identify potential antimalarial agents. Two inhibitors, hesperadin and TAE684, exhibited sub‐micromolar activity across multiple parasite stages, with hesperadin demonstrating significant potency and selectivity by specifically targeting PfArk1.
Henrico Langeveld, Keletso Maepa, Marché Maree, Jessica L. Thibaud, Nicolaas Salomane, Rosie Bridgwater, Mufuliat T. Famodimu, Luiz C. Godoy, Charisse Flerida A. Pasaje, Nonlawat Boonyalai, Mariana Laureano de Souza, Justin Fong, Tayla Rabie, Mariëtte van der Watt, Rensu P. Theart, Sonja Ghidelli‐Disse, Jacquin C. Niles, Marcus C. S. Lee, Elizabeth A. Winzeler, Michael J. Delves, Kelly Chibale, Kathryn J. Wicht, Lauren B. Coulson, Lyn‐Marié Birkholtz   +23 more
wiley   +1 more source

A little nudge goes a long way: assessing the impact of a microbiology nudge comment on narrow-spectrum antibiotic use in uncomplicated <i>Streptococcus pneumoniae</i> bloodstream infections. [PDF]

Antimicrob Steward Healthc Epidemiol
Akon MO, Kenney RM, Everson NA, VanDorf S, Suleyman G, Tibbetts RJ, Shallal AB, Veve MP.   +7 more
europepmc   +1 more source

Perspective on Interdisciplinary Approaches on Chemotaxis

Angewandte Chemie International Edition, EarlyView.
Chemotaxis is the movement of individual organisms towards or away from a chemical stimulus. This phenomenon is investigated in various disciplines, ranging from biology to physics and even engineering. This perspective aims to summarise recent developments in the field and encourage the unification of terminology to promote interdisciplinary knowledge
Juliane Simmchen, Daniel Gordon, John MacKenzie, Ignacio Pagonabarraga, Christina C. Roggatz, Robert G. Endres, Zuyao Xiao, Benjamin M. Friedrich, Tian Qiu, Kevin J. Painter, Ramin Golestanian, Claudia Contini, Mehmet Can Ucar, Gilad Yossifon, Jens Uwe Sommer, Wouter‐Jan Rappel, Kirsty Y. Wan, Judith Armitage, Robert Insall   +18 more
wiley   +1 more source