Results 241 to 250 of about 675,129 (379)

The commensal microbiome is associated with anti–PD-1 efficacy in metastatic melanoma patients

Science, 2018
Vyara Matson, Jessica Fessler, R. Bao, Tara Chongsuwat, Y. Zha, M. Alegre, J. Luke, T. Gajewski   +7 more
semanticscholar   +1 more source

Lactobacillus Salivarius‐Derived Indole‐3‐Acetic Acid Promotes AHR‐PARP1 Axis‐Mediated DNA Repair to Mitigate Intestinal Aging

Advanced Science, EarlyView.
Indole‐3‐acetic acid (IAA) acting as one of the aryl hydrocarbon receptor (AHR) endogenous ligands is identified to be derived from Lactobacillus salivarius via its catalytic enzyme (ALDH) rather than host cells. Lactobacillus salivarius and IAA supplementation effectively mitigate intestinal aging by facilitating AHR‐poly (ADP‐ribose) polymerase 1 ...
Zheng Cao, Cui Zhang, Hehua Lei, Weichuan Lin, Wenkai Yu, Xin Gao, Yanmeng He, Xinzhi Li, Qingwei Xiang, Zhiwen Zhang, Weifei Luo, Andrew D. Patterson, Limin Zhang, Gang Chen   +13 more
wiley   +1 more source

Identification of microbiome-associated loci in super hybrid rice reveals the regulation of OsBRI1 on nitrogen-dependent root microbiome assembly. [PDF]

BMC Plant Biol
Zhang M, Wang Y, Zhang Q, Wang H, Yan Y.
europepmc   +1 more source

Using next‐generation sequencing to detect oral microbiome change following periodontal interventions: A systematic review

, 2020
Ya Zhang, Yinliang Qi, Edward Chin Man Lo, Colman McGrath, May Lei Mei, Ruoxi Dai   +5 more
openalex   +1 more source

Richness of human gut microbiome correlates with metabolic markers

Nature, 2013
E. Chatelier, T. Nielsen, J. Qin, Edi Prifti, F. Hildebrand, G. Falony, Mathieu Almeida, Manimozhiyan Arumugam, Jean-Michel Batto, S. Kennedy, Pierre Leonard, Junhua Li, K. Burgdorf, N. Grarup, T. Jørgensen, I. Brandslund, H. Nielsen, A. S. Juncker, Marcelo Bertalan, F. Levenez, N. Pons, Simon Rasmussen, S. Sunagawa, J. Tap, S. Tims, E. Zoetendal, S. Brunak, K. Clément, J. Doré, M. Kleerebezem, K. Kristiansen, P. Renault, Thomas Sicheritz-Pontén, W. M. Vos, Jean-Daniel Zucker, J. Raes, T. Hansen, P. Bork, Jun Wang, S. Ehrlich, O. Pedersen   +40 more
semanticscholar   +1 more source

Mechanism‐Driven Screening of Membrane‐Targeting and Pore‐Forming Antimicrobial Peptides

Advanced Science, EarlyView.
To combat antibiotic resistance, this study employs mechanism‐driven screening with machine learning to identify pore‐forming antimicrobial peptides from amphibian and human metaproteomes. Seven peptides are validated, showing minimal toxicity and membrane disruption.
Jiaxuan Li, Chenguang Yang, Ruihan Dong, Juan Francisco Bada Juarez, Lei Wang, Maximilian Emanuel Wettstein, Dali Wang, Chan Cao, Ying Lu, Chen Song   +9 more
wiley   +1 more source

Utility of Machine Learning to Characterize Gut Microbiota Dysbiosis and Its Clinical Implications in Inflammatory Bowel Disease. [PDF]

J Inflamm Res
Lee JY, Kim DH, Choi JW, Shong M, Lee CK.   +4 more
europepmc   +1 more source

Microbiome and NAFLD: potential influence of aerobic fitness and lifestyle modification [PDF]

, 2017
Matthew R. Panasevich, Willem T. Peppler, Daniel B. Oerther, David C. Wright, R. Scott Rector   +4 more
openalex   +1 more source

DR5 Governs Compound Exocytosis in Colonic Goblet Cells via TATA‐Box Binding Protein‐Dependent Bestrophin‐2 Transcriptional Regulation

Advanced Science, EarlyView.
DR5 knockout exhibits a thinner colonic mucus layer, leading to mild dysbiosis, increased susceptibility to Citrobacter rodentium invasion, and exacerbated epithelial injury. Mechanistically, DR5 binds transcription factor TBP, which regulates the expression of gene Best2 via its promoter.
Ying Wang, Xinyun Li, Yong Wang, Chuhe Yang, Xiaopei Gao, Ke Zhu, Yihang Ren, Jingxin Li, Chuanyong Liu, Bing Xue   +9 more
wiley   +1 more source

Correction: Altered ruminal microbiome tryptophan metabolism and their derived 3-indoleacetic acid inhibit ruminal inflammation in subacute ruminal acidosis goats. [PDF]

Microbiome
Chen X, Xu J, Zhang L, Xie B, Ren J, He J, Liu T, Liu Q, Dong Y, He X, Yao J, Wu S.   +11 more
europepmc   +1 more source