Results 281 to 290 of about 404,796 (363)
Clinical Pharmacology &Therapeutics, EarlyView.Pharmacomicrobiomics is an emerging field due to important microbiome effects on pharmacokinetics and clinical outcomes. However, the application of this knowledge remains limited. Mycophenolic acid (MPA) is the primary active metabolite of the immunosuppressant, mycophenolate mofetil (MMF).
Abdelrahman Saqr +4 more
wiley +1 more source
Genetic evidence from Mendelian randomization strengthens the causality between oral microbiome and chronic obstructive pulmonary disease. [PDF]
Medicine (Baltimore)Zhou X, Wen F, Qiu H, Li J.
europepmc +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Accurate prediction of oral drug absorption in humans is essential for early drug development; however, physiologically relevant human models are lacking. This study aims to comprehensively assess the EpiIntestinal™, a human primary intestinal 3D model, for its ability to predict oral absorption (Fa), intestinal availability (Fg), CYP3A4 induction, and
Paresh P. Chothe +4 more
wiley +1 more source
The Gut Microbiome: Another Piece in the Puzzle of HIV-Associated Atherosclerosis. [PDF]
J Infect DisSerrano-Villar S, Martínez E.
europepmc +1 more source
Intestinal Barrier Glycosylation for Gut Physiology and Pathology
Barrier Immunity, EarlyView.ABSTRACT The intestinal barrier is a selective structure that safeguards the body from external threats while permitting nutrient absorption and immune surveillance. It consists of the outer mucus layer, the intermediate layer of intestinal epithelial cells (IECs), and the inner layer of immune cells. The proteins in the mucus layer and within IECs are
Girak Kim, Deji Ye, Yikun Yao, Chuan Wu
wiley +1 more source
Associations among HPV persistence, the vaginal microbiome, and cervical cancer recurrence. [PDF]
J Transl MedTsementzi D +7 more
europepmc +1 more source
Redefining the Skin Barrier: A Microbiome‐Integrated Multilayered Defense Model
Barrier Immunity, EarlyView.ABSTRACT The skin constitutes a dynamic interface orchestrating a sophisticated multilayered defense system comprising physical, chemical, immune, and microbial barriers. This review synthesizes current understanding of the structural and functional integration of these barriers, emphasizing their synergistic interactions in maintaining cutaneous ...
Jingjing Xia +4 more
wiley +1 more source
"The microbiome in graft-versus-host disease: a tale of two ecosystems". [PDF]
J Transl MedSoleimani Samarkhazan H +3 more
europepmc +1 more source
Antibiotic‐Induced Microbial Dysbiosis Worsened Outcomes in the Activity‐Based Anorexia Model
International Journal of Eating Disorders, EarlyView.ABSTRACT Objective Anorexia nervosa (AN) is a complex psychiatric disorder characterized by persistent dieting and reduced food intake, leading to significantly low body weight. Dysbiosis in the gut microbiome of patients with AN has been suggested to contribute to the pathogenesis.
Karlijn L. Kooij +15 more
wiley +1 more source