MICROBODIES IN EXPERIMENTALLY ALTERED CELLS [PDF]
A rapid and sustained increase in the number of microbodies in liver and kidney cells can be induced in male rats by ethyl chlorophenoxyisobutyrate (CPIB), a hypolipidemic drug. This phenomenon permits investigation of several aspects of microbody behavior in experimental conditions.
D, Svoboda, H, Grady, D, Azarnoff
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Characterisation of a secreted MFSD6-Fc microbody as a decoy receptor for respiratory enterovirus D68Research in context [PDF]
Summary: Background: Enterovirus D68 (EV-D68) is a prominent non-polio enterovirus known to cause severe respiratory infections and poliomyelitis-like illnesses in children.
Zhaoxue Li +10 more
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Checkpoint inhibitor-expressing lentiviral vaccine suppresses tumor growth in preclinical cancer models [PDF]
Background While immunotherapy has been highly successful for the treatment of some cancers, for others, the immune response to tumor antigens is weak leading to treatment failure. The resistance of tumors to checkpoint inhibitor therapy may be caused by
Thomas D Norton +3 more
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AeiA, an Atg8-interacting protein in Aspergillus oryzae, promotes peroxisome degradation by pexophagy [PDF]
There are two types of autophagy, non-selective (bulk) autophagy, in which substrates are randomly incorporated into autophagosomes, and selective autophagy, in which substrates are specifically targeted.
Takashi Kikuma, Joichiro Nishio
doaj +2 more sources
LOCALIZATION OF ENZYMES WITHIN MICROBODIES [PDF]
Microbodies from rat liver and a variety of plant tissues were osmotically shocked and subsequently centrifuged at 40,000 g for 30 min to yield supernatant and pellet fractions. From rat liver microbodies, all of the uricase activity but little glycolate oxidase or catalase activity were recovered in the pellet, which probably contained the crystalline
A H, Huang, H, Beevers
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Microbodies in experimentally altered cells. IX. The fate of microbodies.
Male rats were given 0.25% CPIB (ethyl chlorophenoxyisobutyrate) for 4 weeks at which time their liver cells showed the typical increase in number of microbodies (peroxisomes). During the first week after withdrawal of CPIB and simultaneous injection of allylisopropylacetamide (AIA), an inhibitor of catalase synthesis, the microbody matrix, in ...
D, Svoboda, J, Reddy
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Isolation of Microbodies from Plant Tissues [PDF]
Specialized microbodies have previously been isolated and characterized from fatty seedling tissues (glyoxysomes) and leaves (leaf peroxisomes). We have now examined 11 other plant tissues, including tubers, fruits, roots, shoots, and petals, and find that all contain particulate catalase, a distinctive common enzyme component of microbodies. On linear
A H, Huang, H, Beevers
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Hansenula polymorpha: An attractive model organism for molecular studies of peroxisome biogenesis and function [PDF]
In wild-type Hansenula polymorpha the proliferation of peroxisomes is induced by various unconventional carbon- and nitrogen sources. Highest induction levels, up to 80% of the cytoplasmic volume, are observed in cells grown in methanol-limited chemostat
Harder, W., +3 more
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SARS CoV-2 Nucleoprotein Enhances the Infectivity of Lentiviral Spike Particles
The establishment of SARS CoV-2 spike-pseudotyped lentiviral (LV) systems has enabled the rapid identification of entry inhibitors and neutralizing agents, alongside allowing for the study of this emerging pathogen in BSL-2 level facilities.
Tarun Mishra +5 more
doaj +1 more source
Microbodies, including peroxisomes, glyoxysomes and Woronin bodies, are ubiquitous dynamic organelles that play important roles in fungal development. The ATP-dependent chaperone and protease family Lon that maintain protein quality control within the ...
Antonia Werner +4 more
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