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Microbubbles for Medical Applications
2014Ultrasound contrast agent (UCA) suspensions contain encapsulated microbubbles with radii ranging from 1 to 10 micrometers. The bubbles oscillate to the driving ultrasound pulse generating harmonics of the driving ultrasound frequency. This feature allows for the discrimination of non-linear bubble echoes from linear tissue echoes facilitating the ...
Segers, T.J. +3 more
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Therapeutic applications of microbubbles
European Journal of Radiology, 2002Microbubbles, currently used as contrast agents have potential therapeutic applications. Microbubbles, upon insonation of sufficiently intense ultrasound will cavitate. Cavitation with microbubbles can be used to dissolve blood clots or deliver drugs. Targeting ligands and drugs can be incorporated into microbubbles to make highly specific diagnostic ...
Evan C, Unger +5 more
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The Onset of Microbubble Vibration
Ultrasound in Medicine & Biology, 2007A linear relationship between the relative expansion of an off-resonance ultrasound contrast microbubble and low acoustic pressures is expected. In this study, high-speed optical recordings of individual phospholipid-coated microbubbles were used to investigate this relationship for microbubbles ranging from 2 to 11 microm and for acoustic pressures ...
Emmer, M. +3 more
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Radial modulation of single microbubbles
IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, 2009Radial modulation imaging is a new promising technique to improve contrast-enhanced ultrasound images. The method is based on dual-frequency insonation of contrast agent microbubbles. A low-frequency (LF) pulse is used to modulate the responses of the microbubbles to a high-frequency (HF) imaging pulse.
Emmer, M. +3 more
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Basic Acoustic Properties of Microbubbles
Echocardiography, 2002Small (encapsulated) gas bubbles in a contrast medium react to an external oscillating pressure field with volume pulsations. Depending on the magnitude of the ultrasound wave, the vibrations will be related either linearly or nonlinearly to the applied acoustic pressure.
Jong, Nico +2 more
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, 2016 Means are provided for supplying a liquid surfactant solution, for supplying a gas under pressure, for mixing the liquid surfactant solution and the pressurized gas to form a liquid coarse dispersion of relatively large gas bubbles, and for receiving the liquid coarse dispersion to generate a liquid fine dispersion of relatively small micron-size gas ...
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HiGee Microbubble Generator: (II) Controllable Preparation of Microbubbles
Industrial & Engineering Chemistry Research, 2022Lan Jiang +6 more
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