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Microcephaly [PDF]

Children, 2017
Microcephaly is defined as a head circumference more than two standard deviations below the mean for gender and age. Congenital microcephaly is present at birth, whereas postnatal microcephaly occurs later in life.
Emily Hanzlik, Joseph Gigante
exaly   +7 more sources

Causes of microcephaly in human—theoretical considerations [PDF]

Frontiers in Neuroscience, 2023
As is evident from the theme of the Research Topic “Small Size, Big Problem: Understanding the Molecular Orchestra of Brain Development from Microcephaly,” the pathomechanisms leading to mirocephaly in human are at best partially understood. As molecular
Michael Heide, Wieland B. Huttner
doaj   +2 more sources

Genetic and clinical features of microcephaly in a prenatal cohort [PDF]

BMC Pregnancy and Childbirth
Background Fetal microcephaly, defined as a small head circumference in utero or at birth, is a rare but clinically significant condition that may be associated with an increased risk of neurodevelopmental delay and impairment. However, the comprehensive
Yi Zhang, Huibing Liu, Ailan Yin, Xin Jiang, Lijun Tang, Siping Liu, Xia Qin, Mei Zhong, Chantao Huang, Bei Jia   +9 more
doaj   +2 more sources

Case Fatality Rate Related to Microcephaly Congenital Zika Syndrome and Associated Factors: A Nationwide Retrospective Study in Brazil †

Viruses, 2020
Background: The clinical manifestations of microcephaly/congenital Zika syndrome (microcephaly/CZS) have harmful consequences on the child’s health, increasing vulnerability to childhood morbidity and mortality. This study analyzes the case fatality rate
Maria Gloria Teixeira, Mauricio L Barreto, Giovanny V A Franca   +2 more
exaly   +3 more sources

Feelings of mothers of infants with microcephaly: a qualitative study

Bioscience Journal, 2018
Microcephaly is a congenital malformation in which the brain does not develop properly. It can be the result of a series of factors, from malnutrition of the mother, drug abuse, infections during pregnancy, among others. In the family context, the birth
Cláudia Maria Sousa de Carvalho, Antônio Adeilson Mendes Pereira, Geany Ferreira de Abreu, Lourena Joyce Matos Paz, Lydia de Carvalho Pires, Camila Aparecida Pinheiro Landim Almeida, Fernanda Cláudia Miranda Amorim, Magda Coeli Vitorino Sales Coêlho, Adélia Dalva da Silva Oliveira, Ana Raquel Batista de Carvalho, Guilherme Guarino de Moura Sá   +10 more
doaj   +5 more sources

A Zebrafish/Drosophila Dual System Model for Investigating Human Microcephaly

Cells, 2022
Microcephaly presents in neurodevelopmental disorders with multiple aetiologies, including bi-allelic mutation in TUBGCP2, a component of the biologically fundamental and conserved microtubule-nucleation complex, γ-TuRC. Elucidating underlying principles
Slawomir Bartoszewski, Mateusz Dawidziuk, Natalia Kasica, Roma Durak, Marta Jurek, Aleksandra Podwysocka, Dorothy Lys Guilbride, Piotr Podlasz, Cecilia Lanny Winata, Pawel Gawlinski   +9 more
doaj   +2 more sources

The association between Zika virus infection and microcephaly in Brazil 2015–2017: An observational analysis of over 4 million births

PLoS Medicine, 2019
BackgroundIn 2015, high rates of microcephaly were reported in Northeast Brazil following the first South American Zika virus (ZIKV) outbreak. Reported microcephaly rates in other Zika-affected areas were significantly lower, suggesting alternate causes ...
Oliver J Brady, Aaron Osgood-Zimmerman, Nicholas J Kassebaum   +2 more
exaly   +2 more sources

The Genetics of Primary Microcephaly

Annual Review of Genomics and Human Genetics, 2018
Primary microcephaly (MCPH, for “microcephaly primary hereditary”) is a disorder of brain development that results in a head circumference more than 3 standard deviations below the mean for age and gender.
Byoung-Il Bae, Christopher A Walsh
exaly   +2 more sources

Pyridostigmine-Induced Microcephaly

Pediatric Neurology Briefs, 2000
The association of high-dose pyridostigmine (PYD) during pregnancy with microcephaly and CNS injury in an infant is reported from the Children’s Hospital Los Angeles, CA.
J Gordon Millichap
doaj   +2 more sources

ALEITAMENTO MATERNO DE CRIANÇAS COM MICROCEFALIA NO CONTEXTO DO ZIKA VÍRUS

Cogitare Enfermagem, 2021
Objective: To understand the perceptions of breastfeeding of mothers of children with microcephaly. Method: Descriptive, qualitative study with 12 women conducted at the outpatient clinic of Hospital Regional Materno Infantil de Imperatriz, Maranhão ...
Floriacy Stabnow Santos, Ada Oliveira Borges da Silva, Antônia Sousa Lima, Laise Sousa Siqueira, Paula Gabrielle Gomes Candido, Antonia Iracilda e Silva Viana, Marcelino Santos Neto   +6 more
doaj   +1 more source